Assessment of long-term and recent pesticide exposure among rural school children in Nicaragua

Rodrı́guez, Teresa; Joode, Berna van Wendel de; Lindh, Christian; Rojas, Marianela; Lundberg, Ingvar; Wesseling, Catharina

doi:10.1136/oem.2010.062539

Cited by 22 publications

(16 citation statements)

References 38 publications

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“…Children from agricultural regions of Nicaragua and Thailand have also been shown to have relatively high pyrethroid exposures (Panuwet et al 2009; Rodriguez et al 2012). In a study of 205 children in Thailand, children of agricultural families had significantly higher geometric mean 3-PBA concentrations (0.38 ng/mL) compared to children of non-agricultural families (0.15 ng/mL) (Panuwet et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: Distribution and relationships with child neurodevelopment

Watkins

Fortenberry

Sánchez

et al. 2016

Environmental Research

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Background In recent years, pyrethroid pesticide use has increased in Mexico, the United States, and elsewhere, resulting in extensive human exposure. There is growing concern that pregnant women may be a particularly vulnerable population, as in utero fetal exposure during critical periods of development could adversely affect long-term neurobehavioral function. Methods We measured maternal urinary 3-phenoxybenzoic acid (3-PBA) concentrations during the third trimester of pregnancy as a measure of in utero pyrethroid exposure to the fetus among participants in an established Mexico City birth cohort (n=187). In a subset of mothers, we measured 3-PBA during the first, second, and third trimester (n=21) to assess variability across pregnancy. We examined associations between third trimester 3-PBA concentrations and children’s scores on the Mental Development Index (MDI) and Psychomotor Development Index (PDI) from the Bayley Scales for Infant Development (BSID-IIS) at 24 and 36 months of age. Results 3-PBA was detected in 46% of all urine samples, with similar detection rates and geometric mean concentrations across pregnancy among the 21 participants who provided repeat samples. Participants in the medium and high 3-PBA categories (≥LOD) had lower MDI scores at 24 months compared to those in the low 3-PBA category (

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Section: Discussionmentioning

confidence: 99%

Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: Distribution and relationships with child neurodevelopment

Watkins

Fortenberry

Sánchez

et al. 2016

Environmental Research

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“…In the sugarcane industry, herbicides are the most used pesticides, and a mixture of 2,4-D, terbutryn, and ametryn is commonly used in the sugar production process in the study area (33). Subsistence farmers use organophosphate and pyrethroid insecticides (included in this study), as well as paraquat (34,35). Detectable levels of 2,4-D, 3-PBA, DCCA, ETU, TEB-OH and TCP were found in the majority of samples tested from both the stable and the declining kidney function groups.…”

Section: Key Resultsmentioning

confidence: 99%

Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy

et al. 2019

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ObjectivesThere is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case–control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of characterising the associations between urinary concentrations of metals, pesticides and mycotoxins from samples collected in the first 6 months and decline in kidney function over 2 years.MethodsUrine samples collected at baseline (pre-sugarcane harvest) and the first 6 month follow-up (post-sugarcane harvest) visit were tested. Twelve metals and metalloids (aluminium, total arsenic, cadmium, chromium, cobalt, copper, lead, manganese, mercury, selenium, silicon and strontium) were analysed by inductively coupled plasma-mass spectrometry. Twelve pesticides or their metabolites (2,4-dichlorophenoxyacetic acid, 3-phenoxybenzoic acid, 4-fluoro-3-phenoxybenzoic acid, chloro-3,3,3-trifluoro-1-propen-1-yl-2,2-dimethylcyclopropanecarboxylic acid, cis/trans 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid, ethylenethiourea, glyphosate, 4-chloro-2-methylphenoxy acetic acid, 3-hydroxy-pyrimetanil, 5-hydroxytiabendazole, hydroxy-tebuconazole and 3,5,6-trichloro-2-pyridinol) and two mycotoxins (ochratoxin A (OTA) and citrinin (CIT)) were analysed by liquid chromatography coupled-mass spectrometry. Differences in the creatinine-corrected urinary concentrations of the measured exposures between outcome groups (participants with stable vs declining kidney function) were examined.ResultsElevated levels of aluminium and total arsenic as well as metabolites of several pesticides were detected across the population. No differences were identified between the declining and stable groups in the levels of metals or pesticides tested. OTA and CIT were below the limit of detection.ConclusionsThe tested metals, metalloids, pesticides and mycotoxins were not associated with loss of kidney function in participants at-risk of MeN.

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“…A utilização de índices como horas, dias-acumulados e cargas aplicadas para estimar exposições, especialmente as ocupacionais, é uma técnica eficaz e comumente empregada em estudos dessa natureza 37,40,46,47,48 . Apesar da ausência de significância estatística da OR de tremor essencial dos modelos apresentados entre casos e controles (Tabelas 2 e 3), possui potencial promissor para a estimativa de gradiente dose-resposta e, ao mesmo tempo, agrega conceitos clínicos e toxicológicos básicos para a compreensão dos fenômenos envolvidos.…”

Section: Discussionunclassified

Tremor essencial em guardas de endemias expostos a agrotóxicos: estudo caso-controle

Azevedo

Meyer

2017

Cad. Saúde Pública

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Resumo: Tremor é o distúrbio do movimento mais frequente na população, e pode estar associado a exposição a agrotóxicos. O objetivo foi avaliar a chance de tremor essencial em 442 guardas de endemias do Estado do Rio de Janeiro, Brasil, expostos a agrotóxicos. Foram selecionados 51 casos e 204 controles (1:4). Todos os participantes responderam a um questionário sobre aspectos sociodemográficos, ocupacionais e toxicológicos. A influência da exposição a agrotóxicos sobre o desenvolvimento do tremor foi estimada por regressão logística não condicional, ajustada por covariáveis selecionadas. A idade média da população estudada foi de 49 (DP = 7) anos, sendo a diferença entre casos (média = 50,8; DP = 6,9) e controles (média = 48,5; DP = 6,9) estatisticamente significativa (p = 0,03). Além disso, aqueles com 16 a 16,9 anos de aplicação de agrotóxicos foram os que estiveram sob maior chance de apresentar a doença (OR ajustada = 4,60; IC95%: 1,29-16,41). Nossos resultados sugerem que o período entre 16 e 16,9 anos de aplicação de agrotóxicos teve impacto importante para o desenvolvimento dessa doença.

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Assessment of long-term and recent pesticide exposure among rural school children in Nicaragua

Abstract: Urinary pesticide residues reveal high environmental exposure among children in rural Nicaragua. The quantitative parental pesticide use indices as proxies for children's exposures during different periods may be useful for the evaluation of developmental health effects.

Cited by 22 publications

References 38 publications

Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: Distribution and relationships with child neurodevelopment

Urinary 3-phenoxybenzoic acid (3-PBA) levels among pregnant women in Mexico City: Distribution and relationships with child neurodevelopment

Environmental exposures in young adults with declining kidney function in a population at risk of Mesoamerican nephropathy

Tremor essencial em guardas de endemias expostos a agrotóxicos: estudo caso-controle

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