Diabetic ketoacidosis following chlorothalonil poisoning: Table 1

Fernández‐García, José Carlos; Arrebola, Juan Pedro; González-Romero, Stella; Soriguer, Federico; Olea, Nicolás; Tinahones, Francisco J.

doi:10.1136/oemed-2013-101795

Cited by 9 publications

(5 citation statements)

References 3 publications

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“…Although humans are not exposed to alloxan or sreptozotocin, they are used in animal research on diabetes. Initial human evidence that synthetic chemicals promote the development of diabetes came from patients accidentally or intentionally exposed to pyrinuron (Vacor) [453]. Exposure to this rodenticide resulted in β-cell destruction and the development of type 1 diabetes [454].…”

Section: Mdcs and Metabolism-relevant Diseasesmentioning

confidence: 99%

Metabolism disrupting chemicals and metabolic disorders

Heindel

Blumberg

Cave

et al. 2017

Reproductive Toxicology

822

651

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The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging. However, there is now considerable evidence that other environmental factors may contribute to the rapid increase in the incidence of these metabolic diseases. This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders. It will then specifically focus on the role of endocrine disrupting chemicals (EDCs) in the etiology of obesity, T2D and NAFLD while finally integrating the information on EDCs on multiple metabolic disorders that could lead to metabolic syndrome. We will specifically examine evidence linking EDC exposures during critical periods of development with metabolic diseases that manifest later in life and across generations.

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Section: Mdcs and Metabolism-relevant Diseasesmentioning

confidence: 99%

Metabolism disrupting chemicals and metabolic disorders

Heindel

Blumberg

Cave

et al. 2017

Reproductive Toxicology

822

651

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“…Eight patients with acute chlorothalonil poisoning have been reported, only six of whom ingested the fungicide. 9 , 10 A case series from Sri Lanka reported six patients with intentional chlorothalonil ingestions (and one with a mild inhalational injury). 9 The six patients ingesting chlorothalonil developed a burning sensation of the mouth, throat, and epigastrium, and had dysphagia and vomiting.…”

Section: Discussionmentioning

confidence: 99%

“…The only renal-related effect mentioned in this case report was the presence of intense ketonuria, as expected with DKA; serum markers of kidney function (BUN, creatinine) were not reported. 10 …”

Section: Discussionmentioning

confidence: 99%

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Reversible Acute Kidney Injury Associated with Chlorothalonil Ingestion

Suchard

2017

CPC-EM

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A 43-year-old man ingested a chlorothalonil-containing fungicide in a suicide attempt. The patient was found to have acute kidney injury from acute tubular necrosis on hospital admission (serum creatinine 2.9 mg/dL), although his renal function recovered with hydration and supportive care. Acute toxicity from chlorothalonil ingestion has been described very rarely, and no previous cases have described clinically-significant renal effects.

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“…While accidental or intentional ingestions of a single chemical may be sufficient to cause diabetes in select circumstances (e.g. the rodenticide Vacor 9 and the fungicide chlorothalonil 10 ), it is unlikely that a single chemical will be sufficient to explain the dramatic explosion in global diabetes rates. However, as there are tens of thousands of unique chemicals to which humans are potentially exposed, coordinate exposure to multiple EDCs that additively antagonize critical pathways regulating energy metabolism through complimentary mechanisms may be sufficient to promote cardiometabolic dysfunction, whereas a single signaling disruptor in isolation may be insufficient to drive significant disease.…”

Section: Introductionmentioning

confidence: 99%

Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals

Sargis

2015

Endocrine Disruptors

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The global epidemic of metabolic disease is a clear and present danger to both individual and societal health. Understanding the myriad factors contributing to obesity and diabetes is essential for curbing their decades-long expansion. Emerging data implicate environmental endocrine disrupting chemicals (EDCs) in the pathogenesis of metabolic diseases such as obesity and diabetes. The phenylsulfamide fungicide and anti-fouling agent tolylfluanid (TF) was recently added to the list of EDCs promoting metabolic dysfunction. Dietary exposure to this novel metabolic disruptor promoted weight gain, increased adiposity, and glucose intolerance as well as systemic and cellular insulin resistance. Interestingly, the increase in body weight and adipose mass was not a consequence of increased food consumption; rather, it may have resulted from disruptions in diurnal patterns of energy intake, raising the possibility that EDCs may promote metabolic dysfunction through alterations in circadian rhythms. While these studies provide further evidence that EDCs may promote the development of obesity and diabetes, many questions remain regarding the clinical factors that modulate patient-specific consequences of EDC exposure, including the impact of genetics, diet, lifestyle, underlying disease, pharmacological treatments, and clinical states of fat redistribution. Currently, little is known regarding the impact of these factors on an individual’s susceptibility to environmentally-mediated metabolic disruption. Advances in these areas will be critical for translating EDC science into the clinic to enable physicians to stratify an individual’s risk of developing EDC-induced metabolic disease and to provide direction for treating exposed patients.

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Diabetic ketoacidosis following chlorothalonil poisoning: Table 1

Cited by 9 publications

References 3 publications

Metabolism disrupting chemicals and metabolic disorders

Metabolism disrupting chemicals and metabolic disorders

Reversible Acute Kidney Injury Associated with Chlorothalonil Ingestion

Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals

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