Pestalotheols E–H: Antimicrobial Metabolites from an Endophytic Fungus Isolated from the Tree Arbutus unedo

Abstract

Keywords: Natural products / Structure elucidation / Oxygen heterocycles / Biological activity Four new compounds, pestalotheols E-H (1-4), along with one known metabolite, anofinic acid (5), were isolated from a fungal endophyte, an unidentified Ascomycete. The structures of the new compounds were elucidated by detailed spectroscopic analysis, and the relative stereochemistries of

Endophytic fungi: a reservoir of antibacterials

“…Pestalotheols E-H (258–261) and Anofinic acid (262) (Figure 19 ), were obtained from an unidentified ascomycete of Arbutus unedo . Compounds (258–262) have antibacterial activity against E. coli and B. megaterium (Qin et al, 2011 ).…”

Coniothyren: a new phenoxyphenyl ether from the endophytic fungus,Coniothyriumsp.

“…The increasing number of people with health problems caused by various forms of cancers, drug-resistant bacteria, parasitic protozoans, and fungi is a cause for considerable alarm [1]. Investigations into the secondary metabolites synthesized by micro-organisms isolated from unusual or specialized ecological niches have become an avenue for increasing the chance of finding new bioactive compounds.…”

“…Investigations into the secondary metabolites synthesized by micro-organisms isolated from unusual or specialized ecological niches have become an avenue for increasing the chance of finding new bioactive compounds. Endophytes, commonly present in almost all plants, are being recognized as a potential source of useful medicinal compounds [1]. Continuing our work on the characterization of structurally novel and/or biologically active metabolites isolated from fungal endophyte cultures [1][2][3][4][5][6][7][8][9][10], we investigated the endophytic fungus Coniothyrium sp., consisting of Fucus sp.…”

“…Endophytes, commonly present in almost all plants, are being recognized as a potential source of useful medicinal compounds [1]. Continuing our work on the characterization of structurally novel and/or biologically active metabolites isolated from fungal endophyte cultures [1][2][3][4][5][6][7][8][9][10], we investigated the endophytic fungus Coniothyrium sp., consisting of Fucus sp. that resulted in the isolation and structural determination of one new phenoxyphenyl ether, named coniothyren (1), together with two known compounds, coniol (2) and (þ)-epoxydon (3).…”

Antifungal Secondary Metabolites Produced by the Fungal Endophytes: Chemical Diversity and Potential Use in the Development of Biopesticides

“…In vitro antifungal assay indicated that 85 displayed potent inhibition of the test eight plant pathogenic fungi; of particular note was the antifungal activity against B. cinerea and Colletotrichum orbiculare with the EC 50 of 0.6 and 1.4 μM, respectively ( Zhao et al, 2012 ). Four new metabolites, pestalotheols E-H (86-89), containing a reduced tetrahydro-2 H -furo[3,2- g ]chromene unit, were isolated from a fungal endophyte, an unidentified Ascomycete from the tree Arbutus unedo ( Qin et al, 2011 ). Compounds 86-89 showed antifungal activity against Microbotryum violaceum , with the radius of the inhibition zone of 6, 8, 6, and 7 mm, respectively, at 50 μg of test substance/test filter disk ( Qin et al, 2011 ).…”