Coniothyren: a new phenoxyphenyl ether from the endophytic fungus,Coniothyriumsp.

Hussain, Hidayat; Kock, Ines; Al‐Harrasi, Ahmed; Abbas, Ghulam; Rehman, Najeeb Ur; Shah, Aamer Ali; Badshah, Amin; Rana, Usman Ali; Noureen, Zakira; Green, Ivan R.; Draeger, Siegfried; Schulz, Barbara; Krohn, Karsten

doi:10.1080/10286020.2014.931843

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…These data were similar to those of 3,4-dihydroxybenzadehyde (protocatechuic aldehyde) moiety (Ooike et al, 1997). The methylene protons H-7′ coupled to C-4′, C-3′ and C-5′ indicated the ethanol moiety attached to C-3′ of the A2B2 aromatic ring, which suggested the structure of 4-(2-hydroxyethyl) -phenol (tyrosol) moiety (Hussain et al, 2014). Based on these data, the structure of 1 consisted of protocatechuic aldehyde and tyrosol fragments.…”

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confidence: 73%

Cytotoxic phenolic constituents from the leaves of Ehretia asperula

Kim

Nguyet

Anh

et al. 2019

Bangladesh J Pharmacol

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Cytotoxic phenolic constituents from the leaves of Ehretia asperula Sir, The genus Ehretia is mainly distributes in tropical areas of Asia, Africa, Northern America and exhibited valuable pharmacologial properties (Li et al., 2010; Shukla and Kaur, 2018). In Vietnam, Ehretia asperula Zoll. & Mort. has been used in traditional medicine for the treatment of ulcer, tumors, liver disease and inflammation (Nguyen et al., 2017). To date, there are few reports about the biological activities and chemical composition of this plant.

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supporting

confidence: 73%

Cytotoxic phenolic constituents from the leaves of Ehretia asperula

Kim

Nguyet

Anh

et al. 2019

Bangladesh J Pharmacol

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“…The plant is thought to provide nutrients to the endophytic fungi, while the microbe may produce factors that protect the host plant from attack by animals, insects or other microbes 12 . It has been proven that endophytic fungi are a source of providing secondary metabolites diverse in structure and biologic activity 13,14 . Thus, the endophytic fungi in C. acuminata plant are expected to be a potential source for CPT or new natural bioactive agents.…”

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confidence: 99%

Characterization and antitumor activity of camptothecin from endophytic fungus Fusarium solani isolated from Camptotheca acuminate

Ran

Zhang

et al. 2017

Afr H. Sci.

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Background: Camptothecin (CPT) is a potent drug against cancers, originally from plants. The endophytic fungi could produce the secondary metabolite same as the host and is used as medicine. Objectives:The aim of this paper was to investigate an endophytic fungal CPT with anti-neoplastic activity. Methods: Endophytic fungi were isolated from Camptotheca acuminata in China. CPT from strain S-019 was characterized by TLC, HPLC and EI-MS analysis. Anti-tumor activity of fungal CPT was detected by MTT and fluorescent dye methods using Vero and PC-3 cells. Results: A total of 94 endophytic fungi strains were isolated from tissues of C. acuminata and 16 fungi strains displayed cytotoxic activity on Vero or PC3 cells. Of which, the fungal strain S-019, classified as Fusarium solani, displayed impressive cytotoxic activity on cancer cells and was found to produce CPT by analysis of TLC, HPLC and EI-MS methods. Bioassay studies confirmed that the fungi CPT had potent cytotoxicity on Vero cells and induced apoptosis of Vero cells. Conclusion:The endophytic fungi from camptotheca trees are a reliable source for natural anticancer compounds. The endophytic fungi could produce CPT same as plant. The fungal CPT exhibited effective activity at inhibiting cell growth and inducing apoptosis on Vero cells.

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Synthesis of (+)‐Epoxydon, (–)‐Phyllostine, (–)‐RKTS 33, and (–)‐Parasitenone Featuring Selective Sulfonylation and Oxirane Ring Closure of Aldol Cyclization Products

et al. 2020

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Two new synthetic approaches to anhydrogabosines are developed from the polyoxygenated aldol cyclization intermediates, bearing different O‐protecting groups, which were transformed to various gabosine‐type cyclitols. Selective sulfonylation on the required hydroxyl group of the intermediates and the subsequent oxirane ring closure are employed as the key steps in both approaches, by which (+)‐epoxydon, (–)‐phyllostine, (–)‐RKTS 33, and (–)‐parasitenone were synthesized from δ‐d‐gluconolactone.

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Coniothyren: a new phenoxyphenyl ether from the endophytic fungus,Coniothyriumsp.

Cited by 4 publications

References 13 publications

Cytotoxic phenolic constituents from the leaves of Ehretia asperula

Cytotoxic phenolic constituents from the leaves of Ehretia asperula

Characterization and antitumor activity of camptothecin from endophytic fungus <i>Fusarium solani</i> isolated from <i>Camptotheca acuminate</i>

Synthesis of (+)‐Epoxydon, (–)‐Phyllostine, (–)‐RKTS 33, and (–)‐Parasitenone Featuring Selective Sulfonylation and Oxirane Ring Closure of Aldol Cyclization Products

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