Cytotoxic phenolic constituents from the leaves of Ehretia asperula

Kim, Dang Dinh; Nguyet, Vu Thi; Anh, Ha Xuan; Trang, Nguyễn Thị Thu; Chuyen, Nguyen Hong; Hương, Lê Mai; Ha, Tran Thi Hong; Ho, Do Hai; Dat, Nguyen Tien

doi:10.3329/bjp.v14i4.42414

Cited by 2 publications

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References 4 publications

(4 reference statements)

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“…Most likely, the E. asperula is a perennial woody plant and the polyphenol accumulation might not yet enter the main stage, so the influence of AM fungus at this experimental time was not significant. Normally, after two-year growth, the bioactive substances accumulating in E. asperula biomasses are enough to harvest and use (Nguyet et al, 2018;Kim et al, 2019). Maybe, it is still early to see an obvious effect of the AM fungus on the polyphenol production in E. asperula plants.…”

Section: Discussionmentioning

confidence: 99%

“…E. asperula is a perennial woody plant and S. procumbens is an herb. The source of medicinal substances obtained from these species has been studied and proven to have anticancer and anti-inflammatory properties (Nguyen et al, 2017;Nguyet et al, 2018;Kim et al, 2019;Tran et al, 2019). However, studies on the effects of microflora in general or AM fungi in particular on the growth and production of medicinal substances of these two species are very few.…”

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confidence: 99%

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Effect of arbuscular mycorrhizal fungus on the growth and polyphenol production of medicinal plants: Ehretia asperula and Solanum procumben

BUI

et al. 2022

Not Bot Horti Agrobo

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The study was conducted to evaluate the influence of arbuscular mycorrhizal fungus (Rhizophagus intradices) on growth and polyphenol production of the two important and popular medicinal plants in Vietnam: Ehretia asperula Zoll. & Mor. and Solanum procumbens Lour. The results showed a significant effect of the fungus on the growth of these two species with the growth indices such as height, weight and P content that were all higher than those of non-AM plants; although the indices of AM symbiosis in the plant roots were not as high as other plants in previous studies. The effect of AM fungus on polyphenol production was different between the two species. In E. asperula, the effect of AM fungi on polyphenol production was not significant; whereas in S. procumbens, AM symbiosis significantly increased polyphenol production in plant biomass, especially in roots. The different growth times of the two species might cause the different effects of AM fungus on polyphenol production.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of arbuscular mycorrhizal fungus on the growth and polyphenol production of medicinal plants: Ehretia asperula and Solanum procumben

BUI

et al. 2022

Not Bot Horti Agrobo

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“…Some researchers have recently revealed the potential pharmacological effects of E asperula in cancer treatment 13 , but there are no trial results using E asperula in cancer therapy. One study identified that the leaves of E asperula contained several constituents with anti-cancer properties, but the underlying mechanisms responsible for these effects are unknown 14 . Only a few reports to date have characterized the chemical components of this plant and their biological effects, particularly on eye disease.…”

Section: Introductionmentioning

confidence: 99%

Protection Against Oxidative Stress-Induced Retinal Cell Death by Compounds Isolated From Ehretia asperula

Kang

Thi

et al. 2021

Natural Product Communications

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Ehretia asperula ( E asperula) is a well-known traditional medicinal plant in Vietnam with potent activity against a wide range of diseases, including hepatitis B and various cancers. Although E asperula has been used in traditional medicine, the efficacy of E asperula and its bioactive components on retinal degenerative diseases has not been fully evaluated. In present this study, we found that ethanolic extracts of E asperula increased cell viability in retinal precursor cells exposed to glutamate/BSO-induced excitotoxicity/oxidative stress. The major responsible bioactive compounds were rosmarinic acid and methylrosmarinic acid. First, 10 known compounds were isolated from E asperula leaves. Their chemical structures were determined using 1D and 2D nuclear magnetic resonance, and compared with published data. Using high-performance liquid chromatography, we determined the content of 4 compounds in E asperula extract: rosmarinic acid, lithospermic acid B, astragalin, and kaempferol 3-rutinoside. The most abundant of these compounds was lithospermic acid B. The protective effects of the pure compounds and ethanolic extracts against excitotoxicity and oxidative stress-induced retinal cell death were tested in R28 cells. Both 70% and 95% ethanolic extracts of E asperula increased cell viability in these conditions. Rosmarinic acid and methyl rosmarinic acid were more effective at protecting against retinal cell death and elevated reactive oxygen species in cells subjected to glutamate/BSO-induced excitotoxicity/oxidative stress. These findings suggested that E asperula could potentially be used to treat retinal degeneration.

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Cytotoxic phenolic constituents from the leaves of Ehretia asperula

Cited by 2 publications

References 4 publications

Effect of arbuscular mycorrhizal fungus on the growth and polyphenol production of medicinal plants: Ehretia asperula and Solanum procumben

Effect of arbuscular mycorrhizal fungus on the growth and polyphenol production of medicinal plants: Ehretia asperula and Solanum procumben

Protection Against Oxidative Stress-Induced Retinal Cell Death by Compounds Isolated From Ehretia asperula

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