Antifungal Secondary Metabolites Produced by the Fungal Endophytes: Chemical Diversity and Potential Use in the Development of Biopesticides

Xu, Kuo; Li, Xiuqi; Zhao, Dong‐Lin; Zhang, Peng

doi:10.3389/fmicb.2021.689527

Cited by 43 publications

(36 citation statements)

References 82 publications

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“…niveum, Fusarium oxysporum f. sp. vasinfectum, and Gibberella saubinettii), with MIC values of 13.7-100 μM, which were comparable to the positive controls (Xu et al, 2021).…”

Section: Antifungal Activitymentioning

confidence: 53%

Isolation of Endophytic Fungi from Algerian Plant Salicornia arabica and Screening of their Antimicrobial Activity

Sadrati¹,

Zerroug²,

Nedjemeddine³

et al. 2022

Turkish JAF Sci.Tech.

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The present study was aimed at isolating endophytic fungi from the Algerian medicinal plant Salicornia arabica and analyzing its antifungal and antibacterial effects. The morphological analysis allowed us to identify endophyte isolates at the genus level as belonging to 8 different genera, Aureobasidium sp., Ulocladium sp., Acremonium sp., Stemphylium sp., Penicillium sp., Aspergillus sp., Phoma sp., and Chrysosporium sp. with frequency percentages 6.7%, 13.3%, 20%, 13.3%, 13.3%, 13.3%, 6.7%, 6.7%, respectively. The antimicrobial activity was caried out using the agar plug diffusion method. The three isolates of the genus Acremonium sp. were highly active against all tested bacteria except Enterococcus faecalis. Comparison of the means of inhibition zones of the active isolates showed that the three fungal isolates of Acremonium were the most active, followed by Chrysosporium sp., Penicillium sp.1, Aureobasidium sp., Stemphylium sp.1, Penicillium sp. .2, and Ulocladium sp.2. The widest zones of inhibition were 22.33 and 20.33mm for Acremonium sp.3, 18.33 and 15.33mm for Aureobasidium sp., 19.33mm for Penicillium sp.1, and 19 and 15mm for Stemphylium sp.1 obtained against Bacillus cereus and Staphylococcus aureus bacteria, respectively. Regarding the antifungal activity, the best inhibitory activity was 80 and 64.70% obtained with the isolate Penicillium sp.2 against Fusarium oxysporum f.sp. ciccri and Fusarium oxysporum f.sp. albedinis, respectively, and of 63.29 and 58% observed against Phytophthora infestans and Fusarium oxysporum f.sp. ciccri, respectively, with the endophytic isolate Aspergillus sp.2. These results indicated the possible prospect of endophytes fungi isolated from Salicornia arabica as a promising resource of antimicrobial compounds and in the quest for the potential starting points for the development of new antibiotics.

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“…niveum, Fusarium oxysporum f. sp. vasinfectum, and Gibberella saubinettii), with MIC values of 13.7-100 μM, which were comparable to the positive controls (Xu et al, 2021).…”

Section: Antifungal Activitymentioning

confidence: 53%

Isolation of Endophytic Fungi from Algerian Plant Salicornia arabica and Screening of their Antimicrobial Activity

Sadrati¹,

Zerroug²,

Nedjemeddine³

et al. 2022

Turkish JAF Sci.Tech.

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“…Within the wide range of secondary metabolites produced by fungi, especially fungal endophytes, many of them have antimicrobial properties, as described in detail by Mousa and Raizada [ 73 ]. Among those antimicrobial metabolites, a thorough review carried out by Xu et al [ 94 ] showed their wide chemical diversity, with a total of 132 chemical structures being found with antifungal properties, when analyzed over the past two decades. From the compounds included in the present review, most of them (53%) are included within the polyketide compounds ( Figure 1 ).…”

Section: Secondary Metabolites Of Fungi With Antifungal Propertiesmentioning

confidence: 99%

Metabolites Produced by Fungi against Fungal Phytopathogens: Review, Implementation and Perspectives

Rodrigo

García-Latorre

Santamaría

2021

Plants

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Many fungi, especially endophytes, have been found to produce multiple benefits in their plant hosts, with many of these benefits associated with the protection of plants against fungal diseases. This fact could be used in the development of new bio-products that could gradually reduce the need for chemical fungicides, which have been associated with multiple health and environmental problems. However, the utilization of the living organism may present several issues, such as an inconsistency in the results obtained and more complicated management and application, as fungal species are highly influenced by environmental conditions, the type of relationship with the plant host and interaction with other microorganisms. These issues could be addressed by using the bioactive compounds produced by the fungus, in cases where they were responsible for positive effects, instead of the living organism. Multiple bioactive compounds produced by fungal species, especially endophytes, with antifungal properties have been previously reported in the literature. However, despite the large amount of these metabolites and their potential, extensive in-field application on a large scale has not yet been implemented. In the present review, the main aspects explaining this limited implementation are analyzed, and the present and future perspectives for its development are discussed.

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“…Endophytic fungi from medicinal plants are known for their ability to produce a variety of bioactive natural products with novel skeletons [1][2][3][4]. Their secondary metabolites, such as alkaloids, terpenoids and polyketides, possess antibacterial, cytotoxic, antiinflammatory, antidiabetic and other biological activities [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Xenoacremones D–H, Bioactive Tyrosine-decahydrofluorene Analogues from the Plant-Derived Fungus Xenoacremonium sinensis

Liu

Wang

et al. 2022

Marine Drugs

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Five novel tyrosine-decahydrofluorene analogues, xenoacremones D–H (1–5), each bearing a fused 6/5/6 tricarbocyclic core and a 13-membered para-cyclophane ring system, were isolated from the endophytic fungus Xenoacremonium sinensis. Compound 1 was a novel polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) tyrosine-decahydrofluorene hybrid containing a 6/5/6/6/5 ring system. Their structures were elucidated from comprehensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All compounds were evaluated for their inhibitory activities on LPS-induced NO production in macrophages and their cytotoxicities against the NB4 and U937 cell lines. Compounds 3 and 5 exhibited potent anti-inflammatory activities in vitro. Compound 1 and 3–5 displayed significant antiproliferative activity against the tumor cell lines (IC50 < 20 µM).

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Antifungal Secondary Metabolites Produced by the Fungal Endophytes: Chemical Diversity and Potential Use in the Development of Biopesticides

Cited by 43 publications

References 82 publications

Isolation of Endophytic Fungi from Algerian Plant Salicornia arabica and Screening of their Antimicrobial Activity

Isolation of Endophytic Fungi from Algerian Plant Salicornia arabica and Screening of their Antimicrobial Activity

Metabolites Produced by Fungi against Fungal Phytopathogens: Review, Implementation and Perspectives

Xenoacremones D–H, Bioactive Tyrosine-decahydrofluorene Analogues from the Plant-Derived Fungus Xenoacremonium sinensis

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