Personalized Healthcare: CMOS Enabled Microfluidic Systems for Healthcare Based Applications (Adv. Mater. 16/2018)

Khan, Sherjeel M.; Gümüş, Abdurrahman; Nassar, Joanna M.; Hussain, Muhammad Mustafa

doi:10.1002/adma.201870111

Cited by 5 publications

(4 citation statements)

References 124 publications

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“…This lab-on-a-chip MFC device possesses numerous features involving programmed functionality, diminutive and exquisite, and biological relevance, which is beneficial for the improvement of integration and portability. [19][20][21][22] Furthermore, the MFC with separation functions has been widely used for biosensing areas involving particle filtration and cell sorting. [23,24] Hence, by utilizing MFC, it is possible to isolate all targeting biomarkers present in a given sample, leading to a substantial enhancement in detection sensitivity without the requirement of amplification techniques.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Chip‐Assisted Upconversion Luminescence Biosensing Platform for Point‐of‐Care Virus Diagnostics

Liu,

Lao,

Wong

et al. 2024

Adv Healthcare Materials

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Epidemics caused by multiple viruses continue to emerge, which have brought a terrible impact on human society. Identification of viral infections with high sensitivity and portability is of significant importance for the screening and management of diseases caused by viruses. Herein, a microfluidic chip (MFC)‐assisted upconversion luminescence biosensing platform has been designed and fabricated for point‐of‐care virus detection. Upconversion nanoparticles with excellent stability are successfully synthesized as luminescent agents for optical signal generation in the portable virus diagnostic platform. The relevant investigation results illustrate that the MFC‐assisted virus diagnostic platform possessed outstanding performance such as good integration, high sensitivity (1.12 pg/ml), ease of use, and portability. In addition, clinical sample test result verifies its more prominent virus diagnostic property than commercially available rapid test strips. All of these thrilling capabilities imply that our designed portable virus diagnostic platform has great potential for future virus detection applications.This article is protected by copyright. All rights reserved

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Section: Introductionmentioning

confidence: 99%

Microfluidic Chip‐Assisted Upconversion Luminescence Biosensing Platform for Point‐of‐Care Virus Diagnostics

Liu,

Lao,

Wong

et al. 2024

Adv Healthcare Materials

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“…The integration of microfluidic channel with CMOS can scale down multiple-stage laboratory procedures in a single chip and process micro and nano-liters samples within a fully isolated manner. Implementing CMOS logic into practice is simple and consumes little to no current in an idle state [ 30 ]. Based on the More Than Moore approach, the CMOS devices’ size is getting smaller and smaller.…”

Section: Introductionmentioning

confidence: 99%

“…This approach, on the one hand, allows more functionality to fit in a smaller area. On the other hand, it can provide the right platform for miniaturized hand-held and versatile microfluidic devices [ 30 ]. Thus far, a lot of setups have been introduced for such applications.…”

Section: Introductionmentioning

confidence: 99%

“…With this background, CMOS-based LoC has been repeatedly reported as one of the most reliable platforms, capable of merging microfluidic with microelectronics, sensors, actuators, and filters as well as micro-electrochemical and microstructure systems into a monolithic device [ 60 , 61 ]. Compared to other DEP-on-a-chip devices, the combination of CMOS technology with DEP has been demonstrated as one of the most prominent devices in diagnostics applications for screening, drug delivery, and disease identification due to their low power consumption, scalability to larger systems like PoC, and high noise immunity [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Characterization and Separation of Live and Dead Yeast Cells Using CMOS-Based DEP Microfluidics

Ettehad

Wenger

2021

Micromachines

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This study aims at developing a miniaturized CMOS integrated silicon-based microfluidic system, compatible with a standard CMOS process, to enable the characterization, and separation of live and dead yeast cells (as model bio-particle organisms) in a cell mixture using the DEP technique. DEP offers excellent benefits in terms of cost, operational power, and especially easy electrode integration with the CMOS architecture, and requiring label-free sample preparation. This can increase the likeliness of using DEP in practical settings. In this work the DEP force was generated using an interdigitated electrode arrays (IDEs) placed on the bottom of a CMOS-based silicon microfluidic channel. This system was primarily used for the immobilization of yeast cells using DEP. This study validated the system for cell separation applications based on the distinct responses of live and dead cells and their surrounding media. The findings confirmed the device’s capability for efficient, rapid and selective cell separation. The viability of this CMOS embedded microfluidic for dielectrophoretic cell manipulation applications and compatibility of the dielectrophoretic structure with CMOS production line and electronics, enabling its future commercially mass production.

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Bi‐Facial Substrates Enabled Heterogeneous Multi‐Dimensional Integrated Circuits (MD‐IC) for Internet of Things (IoT) Applications

et al. 2019

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The primary focus of modern electronics technology is to increase its functionalities within a smaller footprint at an affordable cost. This creates a new set of design challenges for the already‐existing complex integration and packaging schemes. Here, CMOS‐compatible and heterogeneous multi‐dimensional integrated circuits (MD‐IC) as smart electronic systems for Internet of Things (IoT) applications are shown. Both sides of bulk monocrystalline Si (100) substrate for device fabrication which are connected via through‐silicon‐via to transform it into bi‐facial CMOS electronics system are used. As a proof‐of‐concept, cubic, pyramidal, and buckyball shaped MD‐ICs, with broad variety of devices including humidity, temperature, pressure, and pH sensors, solar cells, antenna, microcontroller, light emitting diode and micro lithium‐ion battery are shown. In these MD‐ICs, adjacent sides are interconnected through side‐interlocks. It is also shown that polymeric encapsulation and heterogeneous materials (Si, Ge, and GaSb) can be integrated in the MD‐IC architecture to meet the rigorous requirements of IoT devices. Compared to folded rigid or flexible Printed Circuit Board based electronics, this report shows unprecedented usage of area by device fabrication on both sides which are also connected through‐silicon‐via as state‐of‐the‐art tool for 3D‐IC manufacturing.

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Personalized Healthcare: CMOS Enabled Microfluidic Systems for Healthcare Based Applications (Adv. Mater. 16/2018)

Cited by 5 publications

References 124 publications

Microfluidic Chip‐Assisted Upconversion Luminescence Biosensing Platform for Point‐of‐Care Virus Diagnostics

Microfluidic Chip‐Assisted Upconversion Luminescence Biosensing Platform for Point‐of‐Care Virus Diagnostics

Characterization and Separation of Live and Dead Yeast Cells Using CMOS-Based DEP Microfluidics

Bi‐Facial Substrates Enabled Heterogeneous Multi‐Dimensional Integrated Circuits (MD‐IC) for Internet of Things (IoT) Applications

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