Persisting Paecilomyces lilacinus nail infection following pregnancy

Innocenti, Patrizia; Pagani, Elisabetta; Vigl, Dunja; Höpfl, Reinhard; Huemer, Hartwig P.; Larcher, Clara

doi:10.1111/j.1439-0507.2011.02021.x

Cited by 9 publications

(7 citation statements)

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“…Nail Infection with environmental yeast is a rather rare event and due to the usually high resistance against antifungals is difficult to treat, a finding we also experienced in a still ongoing nail infection with an unusual filamentous fungus recently …”

Section: Discussionmentioning

confidence: 88%

Nail psoriasis masqueraded by secondary infection with Rhodotorula mucilaginosa

Martini

Müller

Huemer

et al. 2013

Mycoses

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A 38-year-old man presented with whitish nail changes on all fingers as the sole symptom. The condition had developed within a few days and led to dystrophy of the proximal part of the nail plates. As microscopic examination of nail scrapings demonstrated budding hyphae and the patient working as a teacher reported frequent use of a wet sponge, antifungal therapy was initiated. Subsequent cultures and molecular typing identified Rhodotorula mucilaginosa (formerly R. rubra). This environmental yeast was repeatedly isolated despite of therapy with itraconazole. As no improvement was achieved and testing of the biological activity of the fungus revealed only marginal keratolytic activity, it was considered as a coloniser of a destructed nail matrix. Finally, a biopsy of the nail bed confirmed the diagnosis of nail psoriasis, which rapidly responded to treatment with acitretin and topical calcipotriol/betamethasone cream. Fungal growth in destructed nails masqueraded the underlying disease and may have triggered the psoriatic nail reaction.

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Section: Discussionmentioning

confidence: 88%

Nail psoriasis masqueraded by secondary infection with Rhodotorula mucilaginosa

Martini

Müller

Huemer

et al. 2013

Mycoses

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“…In our patient, the presence of P. lilacinus and A. alternata in both cutaneous lesions and a toenail suggested nail infection as the source of the fungi. These 2 molds have a worldwide distribution, are found in soil and decaying plants, and are able to cause occasional onychomycosis , especially in cases of altered keratin (often encountered in elderly patients or diabetes mellitus).…”

Section: Discussionmentioning

confidence: 99%

Simultaneous cutaneous infection due to Paecilomyces lilacinus and Alternaria in a heart transplant patient

Lavergne¹,

Cassaing²,

Nocera

et al. 2012

Transplant Infectious Dis

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“…In previous reports of P. lilacinus onychomycosis, oral terbinafine and topical amorolfine and clotrimazole have failed to treat the condition [3,4]. Interestingly, susceptibility has been shown to voriconazole, posaconazole, and terbinafine both in vitro and clinically to P. lilacinus keratitis and cutaneous infections [7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Typically, infections caused by this organism are very difficult to treat as it demonstrates resistance to many antifungals [2]. There are only two reports in the literature of onychomycosis caused by P. lilacinus , both with limited treatment success [3,4]. We herein report a case of a patient with onychomycosis due to P. lilacinus, successfully treated with efinaconazole and tavaborole.…”

Section: Introductionmentioning

confidence: 99%

Successful Treatment of Paecilomyces lilacinus Onychomycosis with Efinaconazole and Tavaborole

Evans

Wang

Elewski

2015

Skin Appendage Disord

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Paecilomyces lilacinus, also known as Purpureocillium lilacinum, is a non-dermatophyte mold found in the soil and used as nematocide for crops. P. lilacinus can cause rare opportunistic infections in humans ranging from endocarditis, keratitis, to onychomycosis with significant resistance to conventional antifungals. There are only two cases of onychomycosis caused by P. lilacinus reported in the literature and none that were successfully treated. Here we present a case of successfully treated onychomycosis caused by P. lilacinus with efinaconazole and tavaborole in a patient who had failed treatment with oral fluconazole, itraconazole, terbinafine, and topical ciclopirox and naftifine.

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Persisting Paecilomyces lilacinus nail infection following pregnancy

Cited by 9 publications

References 0 publications

Nail psoriasis masqueraded by secondary infection with Rhodotorula mucilaginosa

Nail psoriasis masqueraded by secondary infection with Rhodotorula mucilaginosa

Simultaneous cutaneous infection due to Paecilomyces lilacinus and Alternaria in a heart transplant patient

Successful Treatment of Paecilomyces lilacinus Onychomycosis with Efinaconazole and Tavaborole

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