Successful Treatment of Paecilomyces lilacinus Onychomycosis with Efinaconazole and Tavaborole

Evans, John M.; Wang, Apphia L.; Elewski, Boni E.

doi:10.1159/000443773

Cited by 14 publications

(11 citation statements)

References 10 publications

(11 reference statements)

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“…Most clinical manifestations are associated with ocular and cutaneous/subcutaneous infections as described by Borba and Brito [9,63,64,65,66,67,68,69,70,71,72,73,74]. More recently, an onychomycosis [75] and a rare case of nasal perforation [76] were published.…”

Section: Pathogenic Paecilomyces Sppmentioning

confidence: 99%

Human Pathogenic Paecilomyces from Food

2018

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Paecilomyces spp. and Byssochlamys spp. are heat-resistant fungi important to industry because they can cause food and beverage spoilage, incurring economic loss. The consequences of food or beverage fungal colonization is the loss of nutritional value, structure and taste, and the possibility of producing toxic secondary metabolites that may result in medical problems. Furthermore, these fungi can infect animals and humans and it is unknown if contaminated foods may be fomites. P. variotii is the principal agent of food spoilage or contamination and it is most frequently associated with human hyalohyphomycosis with clinical manifestations including peritonitis, cutaneous and disseminated infections, among others. Byssochlamys spp. had not been identified as a cause of systemic infection until the case of a dog with a fungal infection, after immunosuppressive therapy. P. variotii has clinical importance because it causes severe infection in immunosuppressed patients and also because the number of immunocompetent infected patients is increasing. This review draws attention to the ability of these species to grow at high temperatures, to colonize food products, and to cause human disease.

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Section: Pathogenic Paecilomyces Sppmentioning

confidence: 99%

Human Pathogenic Paecilomyces from Food

2018

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“…The incidence of hyalohy-phomycosis due to this organism is on the rise and is associated with a mortality of around 25% [4]. It causes sinusitis, keratitis, wound infections, as well as skin and nail infections like onychomycosis, vaginitis, and endophthalmitis [ 5 - 7 ]. Deep infections are rare, though a case of osteomyelitis [ 2 ] and a case of disseminated disease [ 7 ] have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…It causes sinusitis, keratitis, wound infections, as well as skin and nail infections like onychomycosis, vaginitis, and endophthalmitis [ 5 - 7 ]. Deep infections are rare, though a case of osteomyelitis [ 2 ] and a case of disseminated disease [ 7 ] have been reported. Though toe nail onychomycosis has been described previously [ 6 ], subcutaneous involvement of the lower limbs has not been reported to the best of our knowledge.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of Hyalohyphomycosis due to Purpureocillium lilacinum in a patient with Myasthenia gravis

Raghavan

Chithra

Fernandez

et al. 2018

CMM

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Background and Purpose: Purpureocillium lilacinum (previously known as Paecilomyces lilacinus) and Paecilomyces variotii cause hyalohyphomycosis.Case report:In this study, we present a case of multiple subcutaneous abscesses of the lower limbs due to Purpureocillium lilacinum in a patient with myasthenia gravis and uncontrolled diabetes. Subcutaneous involvement of the lower limbs with this fungus is an unusual presentation. Pus aspirate collected on multiple occasions revealed hyaline septate hyphae under microscopic examination and Purpureocillium lilacinum grew on Sabouraud Dextrose Agar. The patient was initially treated by surgical excision and itraconazole therapy. Swelling regressed but discharge was noticed from the excision site after three months of itraconazole therapy. Culture from the discharge material yielded the same fungal growth. Treatment was changed to ketoconazole and he responded.Conclusion: This case report emphasizes the importance of identifying Purpureocillium lilacinum at an unusual site like the lower limbs in an immunocompromised patient. Ketoconazole may be used as an alternative treatment option for hyalohyphomycosis caused by Purpureocillium lilacinum.

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“…It has broad-spectrum antifungal activity including dermatophytes, such as T. rubrum and T. mentagrophytes, C. albicans , and nondermatophytic moulds. [ 19 45 46 ]…”

Section: Novel Agentsmentioning

confidence: 99%