Persistent Luminescence Nanoplatform with Fenton-like Catalytic Activity for Tumor Multimodal Imaging and Photoenhanced Combination Therapy

Abstract

Reactive oxygen species-mediated tumor chemodynamic therapy and photodynamic therapy have captured extensive attention in practical cancer combination therapies. However, the severe treatment conditions and the hypoxic microenvironment of solid tumors significantly limit the efficacy of these therapies. This work demonstrates the design and fabrication of a multifunctional persistent luminescence nanoplatform (PHFI, refers to PLNP-HSA-Fe3+-IR780) for cancer multimodal imaging and effective photoenhanced combination therapy. The near-infrared-emitted persistent luminescence nanoparticles (PLNP) was modified with human serum albumin (HSA) combined with an IR780 probe and Fe3+. The synthesized PHFI possesses high longitudinal relaxivity, obvious photoacoustic contrast signals, and long-lasting persistent luminescence, indicating that PHFI can be used for cancer magnetic resonance imaging, photoacoustic imaging, and persistent luminescence multimodal imaging. PHFI shows intrinsic photoenhanced Fenton-like catalytic activities as well as photodynamic and photothermal effects and thereby can effectively overcome severe treatment conditions for killing tumor cells. It is worth noting that PHFI serving as a rechargeable internal light source for photoenhanced combination therapy was first disclosed. We believe that our work shows the great potential of PHFI for cancer theranostics and will advance the development of PLNP-based nanoplatforms in tumor catalytic therapy.

Persistent luminescence nanoparticles for cancer theranostics application

“…Zhang et al designed a PersL nanoplatform (PHFI) which co-doped human serum albumin (IR780 iodien and Fe 3+ ) was coated on PLNPs (Fig. 16 a) [ 130 ]. The PHFI were used for MR/PA/PersL imaging of tumors (Fig.…”

“…d Tumor-growth profiles of tumor-bearing mice with different treatment. (Reproduced with permission [ 130 ]. Copyright 2020, American Chemical Society) …”

Chemodynamic nanomaterials for cancer theranostics

“…However, PDT has been limited by several unresolved challenges, such as inefficient therapeutic efficiency as a result of the hypoxic TME [ 142 ]. Recently, the combination of Fenton and Fenton-like reactions with PDT has been demonstrated to enhance the therapeutic antitumor effect [ 143 , 144 ].…”

Which is Better for Nanomedicines: Nanocatalysts or Single‐Atom Catalysts?

“…In recent years, many nanocatalysts and SACs have been used to induce Fenton or Fenton‐like reaction in tumors. In addition to Fe 2+ and Fe 3+ , [ 173 ] other metal ions, such as Mn 2+ , [ 174 ] Cu 2+ , [ 175 ] Pd 2+[ 176 ] can be used as catalysts to trigger the Fenton reaction in the tumor. Moreover, SACs have catalytic active centers (such as MNx), which can be endogenously triggered.…”