2021
DOI: 10.1186/s12951-021-00862-z
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Persistent luminescence nanoparticles for cancer theranostics application

Abstract: Persistent luminescence nanoparticles (PLNPs) are unique optical materials that emit afterglow luminescence after ceasing excitation. They exhibit unexpected advantages for in vivo optical imaging of tumors, such as autofluorescence-free, high sensitivity, high penetration depth, and multiple excitation sources (UV light, LED, NIR laser, X-ray, and radiopharmaceuticals). Besides, by incorporating other functional molecules, such as photosensitizers, photothermal agents, or therapeutic drugs, PLNPs are also wid… Show more

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Cited by 61 publications
(64 citation statements)
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References 134 publications
(165 reference statements)
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“…Luminescent materials are used in the development of optical devices and biomedical equipment for water splitting, CO 2 reduction, environmental purification, photosynthesis and agriculture. At present, different luminescent materials have been developed, such as metal complexes, semiconductors, nanoparticles, fluorescent proteins, organic dyes and luminophores based on donor-acceptor pairs within a metal-organic framework [1][2][3][4][5]. Luminophores are interesting in that they serve as a binder for nanoparticles and can themselves be an additional photoconverter of sunlight [5].…”
Section: Introductionmentioning
confidence: 99%
“…Luminescent materials are used in the development of optical devices and biomedical equipment for water splitting, CO 2 reduction, environmental purification, photosynthesis and agriculture. At present, different luminescent materials have been developed, such as metal complexes, semiconductors, nanoparticles, fluorescent proteins, organic dyes and luminophores based on donor-acceptor pairs within a metal-organic framework [1][2][3][4][5]. Luminophores are interesting in that they serve as a binder for nanoparticles and can themselves be an additional photoconverter of sunlight [5].…”
Section: Introductionmentioning
confidence: 99%
“…OPeH integrates PDT and NIR light-activated enzymes to achieve the combined therapeutic effect of inhibiting tumor growth and lung metastasis. Reproduced with permission from ( Liu N. et al, 2021 ).…”
Section: Strategies For Nanoparticle-based Photocontrolled Deliverymentioning
confidence: 99%
“…One of the key achievements is the production of uniform PLNPs through “bottom‐up” synthesis by a couple of strategies, namely, the templated synthesis, [ 18 ] the aqueous synthesis, [ 19 ] and the colloidal synthesis. [ 20 ] Compared to previous review articles, [ 21–26 ] in this review, we emphasize on the recent important advanced of uniform PLNPs with controlled size and morphology, which represents a promising and fast‐growing direction of the field, especially for the biomedical applications ( Figure ). We first summarized the evolution of the development of uniform PLNPs.…”
Section: Introductionmentioning
confidence: 99%