Permeability of thermally damaged skin II: immediate influences of branding at 60°C on hairless mouse skin permeability

Behl, Charanjit R.; Flynn, Gordon L.; Barrett, Michael T.; Walters, K.; Linn, Edwards E.; Mohamed, Zenaub; Kurihara, Tamie; Ho, Norman F.H.; Higuchi, William I.; Pierson, Carl L.

doi:10.1016/0305-4179(81)90125-x

Cited by 11 publications

(2 citation statements)

References 5 publications

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“…Experimentally, heating or branding has no significant effect on permeation until burn temperature reaches 70 C Behl et al, 1981;Boosalis et al, 1987). At higher temperatures, a notable increase in permeation rate was observed.…”

Section: Heating Brandingmentioning

confidence: 90%

Percutaneous absorption in diseased skin: an overview

Chiang¹,

Tudela²,

Maibach³

2012

J of Applied Toxicology

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The stratum corneum's (SC) functions include protection from external hazardous environments, prevention of water loss and regulation of body temperature. While intact skin absorption studies are abundant, studies on compromised skin permeability are less common, although products are often used to treat affected skin. We reviewed literature on percutaneous absorption through abnormal skin models. Tape stripping is used to disrupt water barrier function. Studies demonstrated that physicochemical properties influence the stripping effect: water-soluble drugs are more affected. Abrasion did not affect absorption as much. Freezing is commonly used to preserve skin. It does not seem to modify water absorption, but still increases the penetration of compounds. Comparatively, heating the skin consistently increased percutaneous absorption. Removing SC lipids may increase percutaneous absorption of drugs. Many organic solvents are employed to delipidize. Delipidization with chloroform-methanol increased hydrophilic compound permeability, but not lipophilic. Acetone pre-treatment enhanced hydrophilic compound penetration. More data is needed to determine influence on highly lipophilic compound penetration. Sodium lauryl sulfate (SLS) induces irritant dermatitis and is frequently used as a model. Studies revealed that SLS increases hydrophilic compound absorption, but not lipophilic. However, skin irritation with other chemicals increases lipophilic penetration as much as hydrophilic. Animal studies show that UV exposure increases percutaneous absorption whereas human studies do not. Human studies show increased penetration in psoriatic and atopic dermatitis skin. The data summarized here begin to characterize flux alteration associated with damaged skin. Understanding the degree of alteration requires interpretation of involved conditions and the enlarging of our database to a more complete physicochemical spectrum.

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Section: Heating Brandingmentioning

confidence: 90%

Percutaneous absorption in diseased skin: an overview

Chiang¹,

Tudela²,

Maibach³

2012

J of Applied Toxicology

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“…Percutaneous penetration is affected by biological factors, too. There is basic variability in the skin barrier, due to factors such as skin hydration level, age, gender, site of the skin surface, malformations due to illness or damage and prior treatment [25][26][27][28][29]. To provide the skin with a healthy barrier function, the hydration level of the skin needs to be balanced, and enough volume of water is needed.…”

Section: Modifying Factors Of Skin Penetrationmentioning

confidence: 99%

Methods to Evaluate Skin Penetration In Vitro

et al. 2019

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Dermal and transdermal drug therapy is increasing in importance nowadays in drug development. To completely utilize the potential of this administration route, it is necessary to optimize the drug release and skin penetration measurements. This review covers the most well-known and up-to-date methods for evaluating the cutaneous penetration of drugs in vitro as a supporting tool for pharmaceutical research scientists in the early stage of drug development. The aim of this article is to present various experimental models used in dermal/transdermal research and summarize the novel knowledge about the main in vitro methods available to study skin penetration. These techniques are: Diffusion cell, skin-PAMPA, tape stripping, two-photon microscopy, confocal laser scanning microscopy, and confocal Raman microscopic method.

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