Permeability of Commercial Solvents Through Living Human Skin

Ursin, C; Hansen, Claus Thorp; Dyk, John W. Van; Jensen, Peter Østrup; Christensen, Ib Jarle; Ebbehoej, J

doi:10.1202/0002-8894(1995)056<0651:pocstl>2.0.co;2

Cited by 25 publications

(30 citation statements)

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“…Sulfolane did not have toxic systemic or irritant effects when applied to guinea pig skin (Brown et al 1966). Ursin et al (1995) found that living human skin showed little permeability to sulfolane (0.2 g m -2 h -1 ). Sulfolane therefore exhibits low levels of toxicity.…”

Section: Introductionmentioning

confidence: 97%

Sulfolane degradation by mixed cultures and a bacterial isolate identified as a Variovorax sp.

Greene

Beatty

Fedorak

2000

Archives of Microbiology

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Sulfolane (tetrahydrothiophene-1,1-dioxide) is used in the Sulfinol process for natural gas sweetening. At many sour-gas processing plants spills, landfills and leakage from unlined surface storage ponds have contaminated groundwaters with sulfolane. Due to its high water solubility and mobility in aquifers, sulfolane poses a risk for off-site contamination. This study investigated the aerobic biodegradation of sulfolane by two mixed microbial enrichment cultures and by three bacterial isolates. Sulfolane served as the sole C, S and energy source for these cultures. In the two mixed cultures, 60% and 80% of the sulfolane C was recovered as CO2, whereas in cultures of the three isolates only 40-42% of the substrate C was recovered as CO,. In the mixed cultures, 81% and 97% of the sulfolane S was converted to sulfate, and in the pure isolates, 55-90% of the substrate S was converted to sulfate. Thus, the mixed cultures were capable of greater mineralization than the pure isolates. One isolate, strain WP1, was identified using a combination of 16S rRNA gene sequencing, physiological traits and cell morphology. WP1 was determined to be most similar to Varioivorax paradoxus.

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Section: Introductionmentioning

confidence: 97%

Sulfolane degradation by mixed cultures and a bacterial isolate identified as a Variovorax sp.

Greene

Beatty

Fedorak

2000

Archives of Microbiology

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“…The dermal absorption of NMP has been investigated previously in tissue samples and animal experiments but the varying approaches make a full comparison between these studies difficult (Ursin et al 1995;Payan et al 2003). In general, the dermal uptake was mainly influenced by skin thickness, desquamation and NMP concentration.…”

Section: Introductionmentioning

confidence: 98%

Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone

Bader

Keener

Wrbitzky

2005

Int Arch Occup Environ Health

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“…Various reports including in vitro testings as well as animal experiments and human studies have shown that the dermal penetration of NMP is comparable with other amphiphilic chemicals such as glycol ethers or N,N-dimethylformamide (e.g., Ursin et al 1995;KeqiT et al 1997;Brooke et al 1998;Nomiyama et al 2001;Jones et al 2003;Korinth et al 2005).…”

Section: Discussionmentioning

confidence: 96%