Peritoneal dialysis related peritonitis due to Mycobacterium spp.: A case report and review of literature

Rohit, Anusha; Abraham, Georgi

doi:10.1016/j.jegh.2016.06.005

Cited by 16 publications

(24 citation statements)

References 15 publications

(29 reference statements)

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“…The diagnosis of NTM and M.abscessus PD peritonitis can be challenging. NTM can cause culture-negative infection, and it is interesting to note that in 4 out of 16 reported cases, the development of PD peritonitis was preceded by catheter replacement for the management of what was deemed to be culture-negative ESI or TI [ 3 , 10 , 11 ]. Clinicians should, therefore be vigilant with regards to possible NTM infection in patients with culture-negative PD peritonitis, particularly in the context of non-responsiveness to standard anti-microbial therapy [ 5 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…PD related peritonitis is most commonly caused by gram-positive aerobes such as coagulase-negative Staphylococci and Staphylococcus aureus, or gram-negative aerobes such as Pseudomonas aeruginosa [ 2 ]. Reports of PD related peritonitis caused by Mycobacterium species are relatively rare, although their incidence has been well documented [ 3 , 4 ]. Nontuberculous mycobacteria (NTM) are members of the genus Mycobacterium but are significantly different from other members of the same genus, e.g., M.tuberculosis and M.leprae.…”

Section: Introductionmentioning

confidence: 99%

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Mycobacterium abscessus - an uncommon, but important cause of peritoneal dialysis-associated peritonitis – case report and literature review

et al. 2020

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Background Peritoneal dialysis (PD) is a form of therapy for end-stage kidney disease (ESKD), and peritonitis is a known complication. Mycobacterium (M) species associated peritonitis in PD patients is uncommon. Our experience of managing PD associated peritonitis caused by M abscessus in a middle-aged man with ESKD due to focal segmental glomerulosclerosis is shared in this article with a review of the literature on this condition. Case presentation A 49-year old man presented to our unit with symptoms of peritonitis and cloudy PD effluent. Initial analysis of PD fluid showed Gram stain was negative, with no organism grown. Empirical PD peritonitis treatment with intra-peritoneal antibiotics did not improve his symptoms and he required intravenous antibiotics, PD catheter removal and a switch to haemodialysis. Cultures of the PD fluid later grew M abscessus, and the antibiotic regimen was changed appropriately, leading to clinical improvement. Conclusion M abscessus associated peritonitis in PD patients is rare. It needs to be borne in mind when clinical improvement is not seen with standard broad-spectrum antibiotics, especially in situations where the PD fluid is initially deemed to be culture negative. PD fluid samples should be sent for acid-fast bacillus and if detected, should be further analysed with genome-wide sequencing to confirm the species of the Mycobacterium. Prompt removal of the catheter with peritoneal washout is critical for clinical improvement.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mycobacterium abscessus - an uncommon, but important cause of peritoneal dialysis-associated peritonitis – case report and literature review

et al. 2020

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“…Recent studies have found that Toll-like receptors, such as TLR-2, that play a key role in the innate immune system are important in host defense against M. tuberculosis 33. Polymorphisms of TLR-2 have been shown to significantly impact susceptibility or resistance to TB 34.…”

Section: Genetic Variablesmentioning

confidence: 99%

“…Polymorphisms of TLR-2 have been shown to significantly impact susceptibility or resistance to TB 34. Though these polymorphisms have generally been studied in pulmonary TB, one series investigated cases of PTB and found that there was a significant association between the GA genotype (heterozygous mutant) of TLR-2 Arg753Gln polymorphism and the risk of infection with PTB 33. This suggests that individuals with genetic polymorphisms of the Arg753Gln portion of TLR-2 may be at increased risk of developing PTB, as compared to those with nonmutant variants.…”

Section: Genetic Variablesmentioning

confidence: 99%

Diagnostic and Therapeutic Strategies for Peritoneal Tuberculosis: A Review

Wu¹,

Averbukh²,

Wu³

2019

Journal of Clinical and Translational Hepatology

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Peritoneal tuberculosis (PTB), although rarer than its pulmonary counterpart, is a serious health concern in regions of the world with high tuberculosis prevalence. Individuals with baseline immunocompromise condition, whether acquired or medically induced, are at greatest risk for experiencing PTB. While medical treatment of the condition is similar to that of the pulmonary disease, the generally immunocompromised state of those infected with PTB, along with a lack of highly sensitive and specific testing methods make early diagnosis difficult. This review discusses the risks factors, clinical features, diagnostic methods, and treatment options for PTB.

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“…This knowledge allows the care and maintenance of their condition of life and health. This is due to the consensus among people with CKD that peritonitis or infection of the peritoneal wall due to contamination due to breakage of technique can lead to failure of the therapeutic modality, hospitalization and death, 19 and results in fear, anguish and guilt.…”

Section: Discussionmentioning

confidence: 99%

Cuidado, Doença E Saúde: Representações Sociais Entre Pessoas Em Tratamento Dialítico

Nascimento

Mantovani

Oliveira

2018

Texto contexto - enferm.

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RESUMO Objetivo: analisar e comparar a estrutura representacional do cuidado com saúde e a doença entre pessoas em tratamento dialítico. Método: pesquisa qualitativa norteada na Teoria das Representações Sociais em sua abordagem estrutural, com 165 participantes, adultos, de ambos os sexos e tratamentos de hemodiálise e dialise peritoneal de quatro serviços de nefrologia em Curitiba e região. Os dados foram coletados entre junho de 2014 e maio de 2015, por meio das evocações livres aos termos indutores "cuidado com a doença" e "cuidado com a saúde" e tratados pelo software Ensemble de Programmes Pemettant L´Analyse des Evoctions e análise do quadro de quatro quadrantes. Resultados: os resultados revelam que as representações de cuidado com a saúde e a doença compartilham conteúdo da doença, mas possui organização distinta, a saúde com o enfoque dos hábitos de vida e dimensão biomédica e a doença ressalta o aspecto avaliativo. Conclusão: as representações de cuidado com a saúde e a doença interagem com comportamentos, atitudes e posicionamentos para o cuidado e fornece elementos para compreensão e apoio dos recursos individuais e ajustes da doença.

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Peritoneal dialysis related peritonitis due to Mycobacterium spp.: A case report and review of literature

Cited by 16 publications

References 15 publications

Mycobacterium abscessus - an uncommon, but important cause of peritoneal dialysis-associated peritonitis – case report and literature review

Mycobacterium abscessus - an uncommon, but important cause of peritoneal dialysis-associated peritonitis – case report and literature review

Diagnostic and Therapeutic Strategies for Peritoneal Tuberculosis: A Review

Cuidado, Doença E Saúde: Representações Sociais Entre Pessoas Em Tratamento Dialítico

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