Peristrophe bicalyculata extract and quercetin ameliorate high fat diet- streptozotocin-induced type ii diabetes in Wistar rats

Iwara, Iwara Arikpo; Mboso, Eve Ofonime; Eteng, Ofem Effiom; Elot, Kelvin Ngwu; Igile, Godwin Oju; Ebong, P. E.

doi:10.1016/j.prmcm.2022.100060

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…This system provided a great increase in the bioavailability of curcumin and quercetin as well as good stability, and was able to restore normal blood levels of glucose, lipid antioxidant biomarkers, and pancreatic and liver tissue architecture in STZ-induced diabetic rats without side effects [ 114 ]. In another study with diabetic rats, quercetin reduced hepatotoxicity, a complication associated with diabetes [ 115 ]. Dong et al investigated the effect of quercetin in type 1 diabetic rats and their findings after a 4-month treatment indicated that quercetin ameliorated oxidative stress-induced cell apoptosis of seminal vesicles via the activation of Nrf2 [ 116 ].…”

Section: Bioactivitymentioning

confidence: 99%

Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

Michala

Pritsa

2022

Diseases

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Quercetin belongs to the broader category of polyphenols. It is found, in particular, among the flavonols, and along with kaempferol, myricetin and isorhamnetin, it is recognized as a foreign substance after ingestion in contrast to vitamins. Quercetin occurs mainly linked to sugars with the most common compounds being quercetin-3-O-glucoside or as an aglycone, especially in the plant population. The aim of this review is to present a recent bibliography on the mechanisms of quercetin absorption and metabolism, bioavailability, and antioxidant and the clinical effects in diabetes and cancer. The literature reports a positive effect of quercetin on oxidative stress, cancer, and the regulation of blood sugar levels. Moreover, research-administered drug dosages of up to 2000 mg per day showed mild to no symptoms of overdose. It should be noted that quercetin is no longer considered a carcinogenic substance. The daily intake of quercetin in the diet ranges 10 mg–500 mg, depending on the type of products consumed. This review highlights that quercetin is a valuable dietary antioxidant, although a specific daily recommended intake for this substance has not yet been determined and further studies are required to decide a beneficial concentration threshold.

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Section: Bioactivitymentioning

confidence: 99%

Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

Michala

Pritsa

2022

Diseases

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“…Lipid metabolism is impacted in the later stages of diabetes and manifests as hyperlipidemia and hypercholesterolemia, which are also risk factors for the disease. Changes in blood parameters are frequent among diabetics, indicating that the function of the blood cells is impaired since diabetes may have a detrimental impact on hematological parameters ( 22 ). By increasing the discharge of insulin and undeniably altering the unstable carbohydrate metabolic enzymes, it was discovered that the mixture of swertiamarin and quercetin (CSQ) had antihyperglycemic and antihyperlipidemic properties.…”

Section: Potential Health Applications Of Quercetinmentioning

confidence: 99%

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

et al. 2022

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Naturally occurring phytochemicals with promising biological properties are quercetin and its derivatives. Quercetin has been thoroughly studied for its antidiabetic, antibacterial, anti-inflammatory, anti-Alzheimer's, anti-arthritic, antioxidant, cardiovascular, and wound-healing properties. Anticancer activity of quercetin against cancer cell lines has also recently been revealed. The majority of the Western diet contains quercetin and its derivatives, therefore consuming them as part of a meal or as a food supplement may be sufficient for people to take advantage of their preventive effects. Bioavailability-based drug-delivery systems of quercetin have been heavily studied. Fruits, seeds, vegetables, bracken fern, coffee, tea, and other plants all contain quercetin, as do natural colors. One naturally occurring antioxidant is quercetin, whose anticancer effects have been discussed in detail. It has several properties that could make it an effective anti-cancer agent. Numerous researches have shown that quercetin plays a substantial part in the suppression of cancer cells in the breast, colon, prostate, ovary, endometrial, and lung tumors. The current study includes a concise explanation of quercetin's action mechanism and potential health applications.

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“…The long chain of aldehydes consists of 12 carbon atoms. According to research by Iwara et al (2022), Peritrophe bicalyculata extract and quercetin administered to a diabetic rat model showed antidiabetic activity. Based on GCMS analysis, the extract contained oleic acid (34.11%), hexadecanoic acid (16.68%), octadecanoic acid (9.97%), 9-octadecenal (8.43%).…”

Section: Identification Of Antidiabetic Compounds Ethyl Acetate Extractmentioning

confidence: 99%

Production of α-Amylase Inhibitors of Aspergillus RD2 from Dewandaru (Eugenia uniflora L.) as Diabetes Drug

Lutfiyah

2022

J Bio Bio Edu

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Diabetes mellitus is a metabolic disorder characterized by above normal blood glucose levels. A α-amylase inhibitors have inhibitory activity against α-amylase enzymes and cause decrease in glucose absorption. Dewandaru (E. uniflora L.) has the potential to produce compounds capable of controlling blood glucose levels. Aspergillus RD2 from twigs of the Dewandaru plant is expected to be able to produce antidiabetic compounds. This study aimed to determine the ability of the Aspergillus RD2 to produce α-amylase inhibitors by determining the production time, extracting α-amylase inhibitor compounds, testing the activity of the supernatant αα-amylase inhibitor and ethyl acetate extract with various concentrations of 2%, 4%, 6%, 8%, 10% and GC-MS analysis. The results showed the Aspergillus RD2 was able to produce αα-amylase inhibitors with an inhibitory activity of 59.71%. The incubation time of the Aspergillus RD2 in producing the highest α-amylase inhibitor was on the 7th day. The highest α-amylase inhibitor activity was at a concentration of 6% extract with an inhibition percentage of 82.79%. 9-Octadecenoic acid, 9-Octadecenal and n-Hexadecanoic acid were identified as having α-amylase inhibitor and antidiabetic activity. Aspergillus RD2 is able to produce α-amylase inhibitor compounds that have the potential to be used as antidiabetic drugs.

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Peristrophe bicalyculata extract and quercetin ameliorate high fat diet- streptozotocin-induced type ii diabetes in Wistar rats

Cited by 5 publications

References 16 publications

Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

Quercetin: A Molecule of Great Biochemical and Clinical Value and Its Beneficial Effect on Diabetes and Cancer

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

Production of α-Amylase Inhibitors of Aspergillus RD2 from Dewandaru (Eugenia uniflora L.) as Diabetes Drug

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