Peripheral T-cell lymphoma unspecified type presenting with a pneumothorax as the initial manifestation: A case report and literature review

Abstract

Abstract. The present study describes the case of a 51-year-old male presenting with a pneumothorax, in whom a final diagnosis of peripheral T-cell lymphoma unspecified type (PTCL-u) was determined. As the patient had experienced a shortness of breath subsequent to exercise for a period of 2 months, a fiber bronchoscopy was performed; however, no abnormalities were initially identified. Following the bronchoscopy, the patient suffered a recurrent pneumothorax with symptoms of emaciation, night sweats and a fever. The combination of computed tomography and interstitial lung pathology results suggested a high probability of malignant lymphoma. Further test results confirmed this diagnosis, including the fiber bronchoscopy biopsy report, which indicated a large amount of lymphocyte aggregation, and an ultrasound that identified several supraclavicular and left submandibular enlarged lymph nodes (largest size, 2.3x1.3 cm), with an absent hilar lymph node. A biopsy of the left cervical lymph node was performed, with post-operative pathological analysis confirming a diagnosis of peripheral T-cell lymphoma unspecified (stage IVB). The patient received two cycles of CHOP chemotherapy, and the symptoms alleviated following completion of the treatment, with chest radiography indicating that the pneumothorax had disappeared. The patient subsequently refused further treatment due to financial difficulty, and succumbed to the disease 6 months later.

Crazy paving pattern as a rare radiological manifestation of peripheral T-cell lymphoma (PTCL) with lung involvement: A case report

“…Lewis et al evaluated CT findings of 31 patients with lung lymphoma and reported that the most frequent finding was a mass/masslike consolidation larger than 1 cm, while the second most common was nodules less than 1cm.The authors did not report any patient with crazy paving pattern in the chest CT [13]. Fu et al (2016) reported a rare case of pneumothorax as first manifestation of PTCL [14]. Three case reports exist concerning crazy paving pattern of PTCL with lung involvement [[15], [16], [17]].…”

Lymphoma Classification in Goats

“…3,4,27 A few individual cases of non-Hodgkin, non–B-cell lymphomas of the lung of humans are published and most commonly classified as extranodal NK/T cell lymphoma (ENKL) based on staining for CD3, granzyme B, and Epstein-Barr virus RNA; other subtypes such as CD3-positive, CD57-negative, EBV-negative PTCL not otherwise specified (NOS) are rare. 17 Testing for NK-specific markers was not performed on the LGL in this series as markers are currently not available for use on formalin-fixed, paraffin-embedded material.…”

“… B, biopsy; B/NH, biopsy and necropsy with histology; B-LLI, B-cell intermediate lymphocytic lymphoma; DLBCL, diffuse large B-cell lymphoma (both centroblastic); I, intermediate; L, large; LN, lymph node; NA, not applicable (information absent) NH, necropsy with histology; PTCL, peripheral T-cell lymphoma; S, small; T-LBL, T-cell lymphoblastic lymphoma; T-LGL, T-cell large granular lymphocytic lymphoma; T-SLL, T-cell small lymphocytic lymphoma. a Average count over 10 fields at 400×. b None of the tumors comprised small lymphocytes when nuclear size was measured relative to caprine red blood cells (RBC) and designated as small (<1.5× RBCs), intermediate (1.5–2× RBCs), or large (>2× RBCs). c The topographic lymphoma distribution was transposed in the previously published retrospective study. 17 …”

“… c The topographic lymphoma distribution was transposed in the previously published retrospective study. 17 …”