Crazy paving pattern as a rare radiological manifestation of peripheral T-cell lymphoma (PTCL) with lung involvement: A case report

Gomatou, Georgia; Tzilas, Vasilios; Kourti, Georgia; Lagou, Styliani; Bouros, Demosthenes; Syrigos, Konstantinos

doi:10.1016/j.rmcr.2018.09.015

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…At time of publication, only two case reports have been found describing a crazy-paving appearance in HRCT of MALToma, later confirmed with histological examination [ 79 , 80 ]. However, a “crazy-paving” appearance in HRCT has been described in some cases of secondary lung involvement, in particular by T-cell lymphomas [ 81 , 82 , 83 ]. Differential diagnosis of patchy or diffuse GGO is mandatory on admission, due to its strong correlation with the patient’s clinical conditions and bio-humoral markers of the patient.…”

Section: Imaging Patternsmentioning

confidence: 99%

Primary Lymphoproliferative Lung Diseases: Imaging and Multidisciplinary Approach

et al. 2023

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Lymphoproliferative lung diseases are a heterogeneous group of disorders characterized by primary or secondary involvement of the lung. Primary pulmonary lymphomas are the most common type, representing 0.5–1% of all primary malignancies of the lung. The radiological presentation is often heterogeneous and non-specific: consolidations, masses, and nodules are the most common findings, followed by ground-glass opacities and interstitial involvement, more common in secondary lung lymphomas. These findings usually show a prevalent perilymphatic spread along bronchovascular bundles, without a prevalence in the upper or lower lung lobes. An ancillary sign, such as a “halo sign”, “reverse halo sign”, air bronchogram, or CT angiogram sign, may be present and can help rule out a differential diagnosis. Since a wide spectrum of pulmonary parenchymal diseases may mimic lymphoma, a correct clinical evaluation and a multidisciplinary approach are mandatory. In this sense, despite High-Resolution Computer Tomography (HRCT) representing the gold standard, a tissue sample is needed for a certain and definitive diagnosis. Cryobiopsy is a relatively new technique that permits the obtaining of a larger amount of tissue without significant artifacts, and is less invasive and more precise than surgical biopsy.

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Section: Imaging Patternsmentioning

confidence: 99%

Primary Lymphoproliferative Lung Diseases: Imaging and Multidisciplinary Approach

et al. 2023

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“…Paving stones are common in alveolar proteinosis, with typical HRCT manifestations of ground-glass density shadow changes in both lungs, thickening of the interlobular septum, and a distinct boundary with the surrounding normal tissues (7,8). The paving stone imaging feature may also be detected in diseases such as pulmonary edema, pulmonary hemorrhage, nodules, non-specific interstitial pneumonia, viral infection, peripheral T-cell lymphoma, and erosive mucinous adenocarcinoma (9)(10)(11)(12)(13). However, in the above diseases, no cases of pneumonia caused due to infection with Prevotella melanogenica are reported so far.…”

Section: Clinical and Imaging Findingsmentioning

confidence: 99%

A case of pulmonary infection with Prevotella melanogenica having the paving stone symptom

et al. 2023

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Prevotella melanogenica is a typical organism present in the human oral cavity and female reproductive tract, which is responsible for causing periodontal disease and the inflammation of the female reproductive tract. The present report discusses the case of a young female patient who presented with cough and fever as the main clinical symptoms. Computed Tomography (CT) revealed multiple clusters of ground glass density shadows in both lungs, with network-like and paving stone-like changes. The alveolar lavage fluid was collected for next-generation sequencing, which revealed the presence of Prevotella melanogenica. The patient received treatments, CT revealed that the density of multiple flakes of ground glass density in both lungs was lower than the previously observed density. Prevotella melanogenica pneumonia is rare, and the paving stone symptom observed in CT is not specific. Therefore, the case reported here provides a novel perspective regarding the diagnosis of pneumonia.

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Crazy paving pattern as a rare radiological manifestation of peripheral T-cell lymphoma (PTCL) with lung involvement: A case report

Cited by 2 publications

References 18 publications

Primary Lymphoproliferative Lung Diseases: Imaging and Multidisciplinary Approach

Primary Lymphoproliferative Lung Diseases: Imaging and Multidisciplinary Approach

A case of pulmonary infection with Prevotella melanogenica having the paving stone symptom

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