Peripheral nerve regeneration using a microporous polylactic acid asymmetric conduit in a rabbit long-gap sciatic nerve transection model

Hsu, Shan‐hui; Chan, Shan-Ho; Chiang, Chih-Ming; Chen, Clayton Chi‐Chang; Jiang, Ching‐Fen

doi:10.1016/j.biomaterials.2011.01.065

Cited by 79 publications

(47 citation statements)

References 28 publications

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“…Whereas the rat clearly represent the species of choice for SCI studies, the use of the latter two animal models of SNI are appropriate when specific research goals are required, namely the mouse for the availability of genetically manipulated animals (Tos e tal., 2008, Willemen et al, 2010in Savastano, Ronchi et al, 2010Eijkelkamp 2010 in Savastano) or the rabbit in case of the study of devices that are too large in comparison to the rat sciatic nerve size, i.e. nerve prostheses longer than 1.5 cm Hsu et al, 2011;Gao et al, 2013).…”

Section: Considerations About Selection Of the Animal Speciesmentioning

confidence: 99%

The sciatic nerve injury model in pre-clinical research

Geuna

2015

Journal of Neuroscience Methods

111

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In the pre-clinical view, the study of peripheral nerve repair and regeneration still needs to be carried out in animal models due to the structural complexity of this organ which can be only partly simulated in vitro. The far most used experimental model is based on the injury of the sciatic nerve, the largest nerve trunk in mammals. In this paper, the potential application of the sciatic nerve injury model in pre-clinical research is critically reviewed. This paper is aimed at helping researchers in properly employing this in vivo model for the study of nerve repair and regeneration as well as interpreting the results in a clinical translation perspective.

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Section: Considerations About Selection Of the Animal Speciesmentioning

confidence: 99%

The sciatic nerve injury model in pre-clinical research

Geuna

2015

Journal of Neuroscience Methods

111

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“…Non-invasive magnetic resonance neurography can be implemented to evaluate nerve damage and/or regeneration, in addition to histology and electrophysiology (Cudlip et al ., 2002;Bendszus et al ., 2004;Hsu et al ., 2011).…”

Section: Morphological Analysismentioning

confidence: 95%

Tailoring the pore structure of foam scaffolds for nerve regeneration

Madaghiele

Salvatore

Sannino

2014

Biomedical Foams for Tissue Engineering Applications

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“…It brings conventional medicine into a new turning point and therefore become very important in modern medicine. Recently, regenerative medicine focuses on growing stem cell in vitro, then implanting them into human body to help self-recovery [1][2][3]. However, the big challenge occurs while culturing stem cells in vitro, because their viability and stemness are subjected to change with microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Image segmentation techniques for stem cell tracking

Jiang

Tsai

2013

2013 IEEE International Conference on Acoustics, Speech and Signal Processing

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To grow stem cells in vitro is an important task in regenerative medicine. Cell motility that can be derived by cell tracking is a useful index to evaluate the viability and stemness of stem cells. The precision of cell tracking is highly dependent on correct detection of the cell centroids, which are usually determined by cell segmentation process. In this study, a cell segmentation method combining doublethresholding and disk-based reconstruction is proposed to solve the problems arising from shape deformation and uneven illumination during cell culture. The qualitative and quantitative comparisons show that the proposed segmentation method increases accuracy in detection the cell centroid.

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Peripheral nerve regeneration using a microporous polylactic acid asymmetric conduit in a rabbit long-gap sciatic nerve transection model

Cited by 79 publications

References 28 publications

The sciatic nerve injury model in pre-clinical research

The sciatic nerve injury model in pre-clinical research

Tailoring the pore structure of foam scaffolds for nerve regeneration

Image segmentation techniques for stem cell tracking

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