Tailoring the pore structure of foam scaffolds for nerve regeneration

Madaghiele, Marta; Salvatore, Luca; Sannino, Alessandro

doi:10.1533/9780857097033.1.101

Cited by 7 publications

(5 citation statements)

References 102 publications

(113 reference statements)

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“…The role of the wound dressing porosity is multiple because it ensures better nutrient transport, gas exchange, and improves absorption properties of the material [ 32 ]. The porosity of the developed chitosan/agarose biomaterial was estimated using microcomputed tomography.…”

Section: Resultsmentioning

confidence: 99%

Highly Porous and Superabsorbent Biomaterial Made of Marine-Derived Polysaccharides and Ascorbic Acid as an Optimal Dressing for Exuding Wound Management

et al. 2021

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There are many modern wound dressings that have promising properties for repairing skin damage. However, due to various types of wounds and the problems they cause, there is still a great demand for new, effective healing strategies. The aim of this study was to create superabsorbent wound dressing made of marine-derived polysaccharides (agarose and chitosan) using the freeze-drying method. The secondary goal was its comprehensive evaluation for potential use as an external superabsorbent bandage for wounds with high exudation. Due to the well-known positive effect of ascorbic acid (vitamin C) on the healing process, biomaterial enriched with vitamin C was prepared and compared to the variant without the addition of ascorbic acid. It was shown that the produced foam-like wound dressing had a very porous structure, which was characterized by hydrophilicity, allowing a large amount of human fluids to be absorbed. According to in vitro tests on human fibroblasts, biomaterial was nontoxic and supportive to cell proliferation. Vitamin C-enriched dressing also had the ability to significantly reduce matrix metalloproteinase-2 production and to promote platelet-derived growth factor-BB synthesis by fibroblasts, which is desired during chronic wound treatment. The material has features of the eco-friendly wound care product since it was made of naturally-derived polysaccharides and was proved to be biodegradable. Importantly, despite degradable character, it was stable in the chronic and infected wound microenvironment, maintaining high integrity after 8-week incubation in the enzymatic solutions containing lysozyme and collagenases. The obtained results clearly showed that developed biomaterial possesses all necessary features of the external dressing for the management of exudate from both acute and chronic non-healing wounds.

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Section: Resultsmentioning

confidence: 99%

Highly Porous and Superabsorbent Biomaterial Made of Marine-Derived Polysaccharides and Ascorbic Acid as an Optimal Dressing for Exuding Wound Management

et al. 2021

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“…When the vessel is regenerated, PLGA/PISEB is expected to vanish as the degradation process is completed. Although clinical trials proved that the biodegradable vascular scaffolds are usually fully degraded in 3 years [ 50 ], a higher degradation rate (as predicted in the case of PLGA/PISEB) could be beneficial to avoid complications associated with a long-term presence of scaffolds [ 4 ]. Even though the assumed process seems to be attractive, further in vivo experimental studies are necessary to fully reveal the applicability of elestrospun PLGA/PISEB as scaffolds for vascular regeneration.…”

Section: Discussionmentioning

confidence: 99%

“…The major limitation of PTFE and PET as vascular scaffold materials is their inability to degrade. The long-term presence of non-degradable material brings the risk of a foreign body reaction and the necessity of a second surgical intervention, i.e., the removal of the scaffold [ 4 ]. It is also known that PTFE and PET have low compliance, poor elasticity, and may induce thrombogenic reactions, leading to the formation of blood clots that could block veins or arteries [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Scaffolds for Vascular Regeneration Based on Electrospun Poly(L-Lactide-co-Glycolide)/Poly(Isosorbide Sebacate) Fibers

Śmiga-Matuszowicz

Włodarczyk

Skorupa

et al. 2023

IJMS

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Vascular regeneration is a complex process, additionally limited by the low regeneration potential of blood vessels. Hence, current research is focused on the design of artificial materials that combine biocompatibility with a certain rate of biodegradability and mechanical robustness. In this paper, we have introduced a scaffold material made of poly(L-lactide-co-glycolide)/poly(isosorbide sebacate) (PLGA/PISEB) fibers fabricated in the course of an electrospinning process, and confirmed its biocompatibility towards human umbilical vein endothelial cells (HUVEC). The resulting material was characterized by a bimodal distribution of fiber diameters, with the median of 1.25 µm and 4.75 µm. Genotyping of HUVEC cells collected after 48 h of incubations on the surface of PLGA/PISEB scaffolds showed a potentially pro-angiogenic expression profile, as well as anti-inflammatory effects of this material. Over the course of a 12-week-long hydrolytic degradation process, PLGA/PISEB fibers were found to swell and disintegrate, resulting in the formation of highly developed structures resembling seaweeds. It is expected that the change in the scaffold structure should have a positive effect on blood vessel regeneration, by allowing cells to penetrate the scaffold and grow within a 3D structure of PLGA/PISEB, as well as stabilizing newly-formed endothelium during hydrolytic expansion.

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“…The possibility to define specific scaffolds properties (i.e., by tuning protein concentration, solvent type and concentration, protein molecular weight, superficial morphology, 3D organization, and by pre- and post-production processing) offers a great opportunity to modulate the structure-related biological activity of the scaffolds in order to optimize their capability to induce and sustain tissue regeneration [ 20 , 35 , 43 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. Moreover, the use of collagen is advantageous for regenerative medicine and tissue engineering applications because, being recognized as a self-molecule, it is metabolized by the natural body enzymatic apparatus that gradually breaks down collagen molecules and substitutes it with newly synthetized one.…”

Section: Collagen As Biomaterialsmentioning

confidence: 99%

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

Salvatore¹,

Natali

Brunetti³

et al. 2023

Polymers

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Soft tissues diseases significantly affect patients quality of life and usually require targeted, costly and sometimes constant interventions. With the average lifetime increase, a proportional increase of age-related soft tissues diseases has been witnessed. Due to this, the last two decades have seen a tremendous demand for minimally invasive one-step resolutive procedures. Intensive scientific and industrial research has led to the recognition of injectable formulations as a new advantageous approach in the management of complex diseases that are challenging to treat with conventional strategies. Among them, collagen-based products are revealed to be one of the most promising among bioactive biomaterials-based formulations. Collagen is the most abundant structural protein of vertebrate connective tissues and, because of its structural and non-structural role, is one of the most widely used multifunctional biomaterials in the health-related sectors, including medical care and cosmetics. Indeed, collagen-based formulations are historically considered as the “gold standard” and from 1981 have been paving the way for the development of a new generation of fillers. A huge number of collagen-based injectable products have been approved worldwide for clinical use and have routinely been introduced in many clinical settings for both aesthetic and regenerative surgery. In this context, this review article aims to be an update on the clinical outcomes of approved collagen-based injectables for both aesthetic and regenerative medicine of the last 20 years with an in-depth focus on their safety and effectiveness for the treatment of diseases of the integumental, gastrointestinal, musculoskeletal, and urogenital apparatus.

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Tailoring the pore structure of foam scaffolds for nerve regeneration

Cited by 7 publications

References 102 publications

Highly Porous and Superabsorbent Biomaterial Made of Marine-Derived Polysaccharides and Ascorbic Acid as an Optimal Dressing for Exuding Wound Management

Highly Porous and Superabsorbent Biomaterial Made of Marine-Derived Polysaccharides and Ascorbic Acid as an Optimal Dressing for Exuding Wound Management

Biodegradable Scaffolds for Vascular Regeneration Based on Electrospun Poly(L-Lactide-co-Glycolide)/Poly(Isosorbide Sebacate) Fibers

An Update on the Clinical Efficacy and Safety of Collagen Injectables for Aesthetic and Regenerative Medicine Applications

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