Perioral Dermatitis Associated With an Inhaled Corticosteroid

Midchildhood Acne Associated with Inhaled Corticosteroids: Report of Two Cases and Review of the Literature

“…Although steroid use may also precipitate periorificial dermatitis, the clear presence of comedones in both of our patients favors midchildhood acne. The temporal relationship between the onset of lesions and steroid use and the location of lesions in the area of cutaneous steroid exposure may suggest a causative relationship that does not necessitate systemic absorption of inhaled steroids. It is possible that the use of a facial mask concentrated exposure to inhaled corticosteroids, leading to irritation and impairment of the skin barrier in the mid‐facial region, similar to the proposed mechanisms of comedogenesis induced by topical steroids.…”

The granulomatous reaction pattern

“…240 Inhaled corticosteroids may also induce the disease. 241 Granulomatous perioral dermatitis of childhood is particularly seen in children of Afro-Caribbean descent. This form has been given the acronym FACE -facial Afro-Caribbean childhood eruption.…”

Patients with airborne sensitization/contact dermatitis from budesonide‐containing aerosols ‘by proxy’

“…Despite the wide use of inhaled corticosteroids (CSs), few cases of asthmatic patients experiencing allergic reactions have been reported (1–18). Isaksson et al (3), who examined patients suffering from asthma or allergic rhinitis treated with tixocortol pivalate, observed a corticosteroids sensitization rate of 1.4%; among non‐asthmatic patients, however, the rate of sensitization was 0.9%, the difference being not statistically significant.…”