Patients with airborne sensitization/contact dermatitis from budesonide‐containing aerosols ‘by proxy’

Abstract

Air exposure to inhalation corticosteroids used 'by proxy' and to budesonide, in particular, needs to be taken into account as a potential cause of primary sensitization and/or airborne allergic contact dermatitis, sometimes also in an occupational context.

Occupational allergic contact dermatitis from systemic drugs

“…However, vapor or dusts formed by crushing tablets for patients with dysphagia also caused OACD on air‐exposed body parts (Figure ) . Similar findings have been reported for nurses and care takers assisting patients in using aerosols …”

“…13 Similar findings have been reported for nurses and care takers assisting patients in using aerosols. 14,15 Of the four community pharmacists with OACD diagnosed between 2001 and 2019, none had OACD from systemic drugs, whereas in the former study between 1978 and 2001, 6 two had been reported. Chemists working in the pharmaceutical industry are said to be at higher risk, as they are involved in manufacturing or laboratory processes.…”

Immediate and delayed allergic hypersensitivity to corticosteroids: practical guidelines

“…The skin is the most likely sensitization route following direct cutaneous application, but indirect contact, including airborne exposure, also occurs; indeed, contact dermatitis and primary sensitization has been induced in healthcare workers and family members by airborne exposure to budesonide-containing aerosols used by patients nearby ('by proxy', connubial, or consort dermatitis) (9).…”

Mesleksel Havayla Taşınan (Airborne) Kontakt Dermatitler

“…Hasta bakı-cılar üzerinde yapılan bir başka çalışmada ise tetrazepama bağlı ABKD bulunan bazı hastalarda benzodiazepinlerle çapraz reaksiyon ile allerjik reaksiyonlar geliştiği tespit edilmiştir (18). Yaşlı ve düşkün hastalara inhaler budesonid uygulayan hasta bakıcılarında da mesleksel ABKD bildirilmiştir (19). Olanzapin (20), simvastatin, karvedilol, zolpidem (21), tylosin (22), omeprazol (23), pristinamisin (24), isofloran buharı (25,26), mesna (25), benzoilperoksit (27), mesleksel allerjik ABKD'e yol açtığı bildirilen diğer ilaçlardır (Tablo-1).…”

“…Ayrıca tahta mücevherat ve müzik enstrümanlarına bağlı da mesleksel allerjiler gelişebilmekte ve bu malzemelerin imalatıyla uğra-şanlarda görülebilmektedir. Ahşaba veya talaşına bağlı kereste işçilerinde, çiftlik hayvanlarının tozlarına bağlı olarak çiftçilerde, çiçek ve bitki tozlarına [10] Usnic asit [28] Pinusroxburghii [30] Budesonid [19] Trimethylolpropanetriacrylat [54] Tarçın tozları [31] Olanzapine [20] Metaakrilatlar Machaeriumscleroxylon [32] Simvastatin [21] 2-Hydroxethyl methacrylate [55] Safran soğanı [33] Carvedilol [21] Triethyleneglycoldimethacrylate [55] Livestock talaşı [34] Zolpidem [21] Ethyleneglycoldimethacrylate [55] Kekik talaşı [35] Tylosin [22] Latex [55] Eucalyptuspulverulenta [36] Omeprazol [23] Epoksi reçineleri [57,58] Pristinamycin [24] Thiuramlar [11,59] Mesna [25] Koruyucular ve diğer kimyasallar İsofloran buharı [26] 4-(bromomethyl)benzoicacid [12] TetramethyluroniumHexafluorophosphate [40] bağlı çiçekçilerde (29-36) mesleksel ABDK vakaları bildirilmiştir.…”