Perioperative infliximab application has marginal effects on ischemia–reperfusion injury in experimental small bowel transplantation in rats

Pech, Thomas; Fujishiro, Jun; Finger, Tobias; Ohsawa, Ichiro; Praktiknjo, Michael; Websky, Martin von; Wehner, Sven; Abu‐Elmagd, Kareem; Kalff, Joerg C.; Schaefer, Nico

doi:10.1007/s00423-011-0853-0

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Previous studies also revealed that infliximab attenuated the reduction in myocardial function observed 30 min after reperfusion in heart of pigs (Niemann et al 2009). However, a recent investigation showed that infliximab increased TNF-α expression 3 h after reperfusion of small bowel in Lewis rats (Pech et al 2012). The difference may be attributed to difference in the model and/or the time point.…”

Section: Discussionmentioning

confidence: 97%

Inhibition of TNF-α protects against hepatic ischemia–reperfusion injury in rats via NF-κB dependent pathway

Mahmoud

Shazly

Barakat

2012

Naunyn-Schmiedeberg's Arch Pharmacol

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Hepatic ischemia-reperfusion injury (I/R) is a serious health problem associated with liver transplantation, resection surgery, and various types of shock especially hemorrhagic shock. In the present investigation, the effect of inhibition of tumor necrosis factor-alpha (TNF-α) using pentoxifylline or infliximab against hepatic I/R injury induced in rats by 45-min ischemia and 1-h reperfusion was studied. It was observed that both pentoxifylline and infliximab-treated groups showed a significantly lower extent and severity of liver injury. This is attributed to (1) a decrease in oxidative stress markers, (2) reduction of the expression of TNF-α, TNF-α type-1 receptors, and nuclear factor kappa B (NF-κB). Thus TNF-α inhibition may be one of the therapeutic interventions to overcome the deleterious effects of I/R on liver via reduction of oxidative stress and inhibition of inflammatory cascade.

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Section: Discussionmentioning

confidence: 97%

Inhibition of TNF-α protects against hepatic ischemia–reperfusion injury in rats via NF-κB dependent pathway

Mahmoud

Shazly

Barakat

2012

Naunyn-Schmiedeberg's Arch Pharmacol

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“…On the basis of our previous findings of a microcirculatory perfusion shift between the intestinal mucosa and muscularis during both kinds of ECC, 6 we would expect a stronger effect on cell death in the intestinal muscularis in the DAP and SVP groups. Besides, in a model of isogenic transplantation, Pech et al 28 found I/R induced damage of the small intestinal muscularis that was reflected by reduced motility after 3 hours and accompanied by an increased number of TUNEL-positive cells after 24 hours of reperfusion. Thus, the stable apoptosis rate in the muscularis throughout our experiment might be explained by delayed occurrence that could not be detected in our setting.…”

Section: Discussionmentioning

confidence: 99%

Extracorporeal circulation increases proliferation in the intestinal mucosa in a large animal model

Keschenau

Ribbe

Tamm

et al. 2016

Journal of Vascular Surgery

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“…The protective effects of infliximab in ischemia-reperfusion injury especially in the small intestine and lungs have been shown in several studies [ 6 , 7 ]. Pech et al showed that perioperative infliximab application has protective effects on ischemia-reperfusion in experimental small bowel transplantation in rats [ 8 ]. The main sources of TNF-alpha in the liver are the Kupffer cells.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Infliximab on Laminin, NFκB, and Anti-TNF Expression through Its Effect on Ischemic Liver Tissue

Akdoğan

Kalkan

Tümkaya

et al. 2016

Gastroenterology Research and Practice

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The aim of this study was to investigate the possible protective effects of infliximab on expression of laminin, anti-TNF, and NFκB in the rat hepatic cells after ischemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into three groups: Control (C), sham I/R (ISC), and I/R+ infliximab (ISC inf); each group comprised 10 animals. C group animals underwent laparotomy without I/R injury. In ISC groups after undergoing laparotomy, 1 hour of superior mesenteric artery ligation was done, which was followed by 1 hour of reperfusion. In the ISC inf group, 3 days before I/R, infliximab (3 mg/kg) was administered intravenously. All animals were killed at the end of reperfusion and hepatic tissue samples were obtained for histopathological and histochemical investigations in all groups. Laminin, anti-TNF, and NFκB immunoreactivity were performed for all groups. ISC caused severe histopathological injury including mucosal erosions, inflammatory cell infiltration, necrosis, hemorrhage, and villous congestion. Infliximab treatment significantly attenuated the severity of intestinal I/R injury and it is shown by laminin, anti-TNF, and NFκB immunoreactivity. Because of its anti-inflammatory and antioxidant effects, infliximab pretreatment may have protective effects on hepatic cells in the experimental intestinal I/R model of rats.

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Perioperative infliximab application has marginal effects on ischemia–reperfusion injury in experimental small bowel transplantation in rats

Cited by 4 publications

References 34 publications

Inhibition of TNF-α protects against hepatic ischemia–reperfusion injury in rats via NF-κB dependent pathway

Inhibition of TNF-α protects against hepatic ischemia–reperfusion injury in rats via NF-κB dependent pathway

Extracorporeal circulation increases proliferation in the intestinal mucosa in a large animal model

The Effects of Infliximab on Laminin, NFκB, and Anti-TNF Expression through Its Effect on Ischemic Liver Tissue

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