Periodontitis as a risk factor for cerebrovascular accident: a case-control study in the Indian population

Pradeep, A.R.; Hadge, Parag; Raju, P Arjun; Shetty, Shreya; Shareef, K.; Guruprasad, C. N.

doi:10.1111/j.1600-0765.2009.01220.x

Cited by 63 publications

(72 citation statements)

References 37 publications

(53 reference statements)

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“…The authors performed clinical (gingival index, BoP, probing depth, CAL) and radiological (bone loss) periodontal examinations [12,45,46,47,48,49,50]. The methodological differences were also demonstrated at the level of stroke diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…The methodological differences were also demonstrated at the level of stroke diagnosis. Some researchers focused on ischemic stroke, binding its occurrence to the formation of atherosclerotic plaque [45,46,49,50]. Other researchers mentioned only a history of stroke in their patients [12,14,47,48].…”

Section: Discussionmentioning

confidence: 99%

“…Smin et al performed measurements at six sites of each tooth present, while other researchers evaluated four sites [45,46,48,49,50]. All these researchers have confirmed that the risk of stroke increases proportionally to the loss of CAL.…”

Section: State Of Knowledgementioning

confidence: 98%

“…At the same time, they found no relationship between ischemic stroke and gingivitis [45]. Hashemipour and Pradeep each studied an average number of patents [46,47]; in turn, Hashemipour et al showed that moderate and advanced periodontitis occurred more frequently in patients after stroke, based on PI, GI and CAL examination [47]. Sim et al, based on a group of 479 patients, established a strong link between stroke and periodontal disease in patients with CAL> 6 mm.…”

Section: State Of Knowledgementioning

confidence: 99%

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Periodontitis as a risk factor of stroke: a review of literature

Michalska¹,

Lewkowicz²

2017

Med Og Nauk Zdr.

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Kulińska-Michalska M.M, Lewkowicz N. Periodontitis as a risk factor of stroke -literature review. Med Og Nauk Zdr. 2017; 23(2): 138-142. doi: 10.26444/monz/74775 Abstract Introduction and objective. Periodontitis is an inflammatory condition affecting tooth-supporting tissues that can interfere with the course of systemic diseases. Currently, the main interest has focused on the interaction between periodontal disease and cardiovascular diseases. State of knowledge. The paper presents current views on the relationship between periodontitis and stroke, based on a search in the Medline and Pubmed databases from 2000-2016. Numerous studies have shown that periodontal inflammation may mediate the formation of ischemic stroke by promoting the growth of atherosclerotic plaque. Periodontitis was assumed to be an independent risk factor for stroke. Conclusions. Prevention and treatment of periodontal disease might inhibit the development of the inflammatory process and consequently the formation of atherosclerotic plaque.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: State Of Knowledgementioning

confidence: 98%

Section: State Of Knowledgementioning

confidence: 99%

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Periodontitis as a risk factor of stroke: a review of literature

Michalska¹,

Lewkowicz²

2017

Med Og Nauk Zdr.

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“…Le facteur de risque vasculaire athéromateux représenté par la maladie parodontale a été suspecté par quelques études épidémiologiques [5][6][7][8]. Plusieurs études récentes cas-témoins [9][10][11][12], études de cohortes [13][14][15][16][17][18][19], études longitudinales et transversales [20,21] ont permis d'établir un lien bien documenté entre la survenue des AVCI et les parodontites.…”

Section: Introductionunclassified

Inflammation buccale et accidents vasculaires cérébraux ischémiques non fatals

Lafon

Tala

Lafon

et al. 2013

Med Buccale Chir Buccale

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Résumé -Objectif : L'inflammation buccale pourrait constituer un facteur de risque des accidents vasculaires cérébraux d'origine ischémique (AVCI).Abstract -Oral inflammation and occurrence of non-fatal ischemic strokes. Objective: Oral inflammation has been described as a presumed risk factor of stroke with ischemic origin. The objective of this study was to investigate the link between oral inflammation, occurrence of non-fatal ischemic strokes without motor or cognitive sequelae (NIH < 1 and Rankin < 1) and pro-atherosclerotic biomarkers. Materials and methods: A retrospective observational study of 48 cases of ischemic stroke and 47 control patients was conducted at the University Hospital of Dijon. A clinical dental examination and dental panoramic were performed one month after the ischemic stroke. Biological data collected on the day of the ischemic stroke (C-reactive protein or CRP, triglycerides, HDL, LDL, glucose) were analyzed. The vascular risk factors were identified. We estimated the odds Med Buccale Chir Buccale 2013;19:211-220

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Periodontitis is a potential risk factor for transient ischemic attack and minor ischemic stroke in young adults: A nationwide population‐based cohort study

Lee

Tsai

Yen

et al. 2022

Journal of Periodontology

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Background: This study aims to determine whether periodontitis is a risk factor for transient ischemic attack (TIA) in young adults. Methods:The National Health Insurance (NHI) Research Database in Taiwan was the source of the data used in this retrospective cohort study. Individuals aged 20 to 53 years with periodontitis in 2001 and 2002 (n = 792,426) and an ageand sex-matched control group (n = 792,426) were selected. All participants were followed up until TIA diagnosis, 55 years of age, removal from the NHI program, death, or December 31, 2016. The incidence density and hazard ratio (HR) of newonset TIA were compared between individuals with periodontitis and controls.Periodontitis was defined by dentists according to the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 523.3-5 with concurrent antibiotic prescription or periodontal treatment excluding scaling performed by certified dentists. TIA was defined according to the ICD-9-CM code 435.x at hospital discharge. Results: After adjustment for confounding factors, the risk of developing TIA/minor ischemic stroke was calculated to be higher in participants with periodontitis (HR, 1.24; 95% confidence interval, 1.15-1.32; P <0.001) than in those without. The HR was slightly higher among people aged 20 to 40 years than among those aged 40 to 53 years. Conclusion: Periodontitis is associated with an increased risk of developing TIA/minor ischemic stroke. Periodontitis might be a modifiable risk factor for stroke in young adults. Clinicians must devote greater attention to this potential association to develop new preventive and therapeutic strategies for stroke in young adults.

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Periodontitis as a risk factor for cerebrovascular accident: a case-control study in the Indian population

Abstract: The data from this study support the proposed link between periodontitis and cerebrovascular accident in the Indian population. However, further studies are necessary to verify and quantify the role of oral infections and genetic factors in the process of atherosclerosis.

Cited by 63 publications

References 37 publications

Periodontitis as a risk factor of stroke: a review of literature

Periodontitis as a risk factor of stroke: a review of literature

Inflammation buccale et accidents vasculaires cérébraux ischémiques non fatals

Periodontitis is a potential risk factor for transient ischemic attack and minor ischemic stroke in young adults: A nationwide population‐based cohort study

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