Periodontitis and risk of immune‐mediated systemic conditions: A systematic review and meta‐analysis

Larvin, Harriet; Kang, Jing; Aggarwal, Vishal R.; Pavitt, S; Wu, Jianhua

doi:10.1111/cdoe.12812

Cited by 17 publications

(12 citation statements)

References 88 publications

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“…Periodontitis is an inflammatory disease characterized by periodontal soft tissue destruction and alveolar bone resorption that destroys periodontal tissue mainly by affecting the host immune system and bone homeostasis and can eventually lead to periodontal ligament loss, gingival retraction and alveolar bone resorption [ [20] , [21] , [22] ]. At present, how to promote periodontal tissue repair and regeneration while controlling infection is a difficult and scientific problem that needs to be solved in the treatment of periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Quercetin through miR-147–5p/Clip3 axis reducing Th17 cell differentiation to alleviate periodontitis

An,

Zhao,

Liu

et al. 2024

Regenerative Therapy

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Section: Discussionmentioning

confidence: 99%

Quercetin through miR-147–5p/Clip3 axis reducing Th17 cell differentiation to alleviate periodontitis

An,

Zhao,

Liu

et al. 2024

Regenerative Therapy

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“…За даними літератури, ризик РА вищий на 27% при пародонтиті порівняно зі здоровим контролем (ОР = 1,27, 95% ДІ = 1,07-1,52). Кількісна оцінка ризику РА при легкому, середньому і тяжкому ступенях пародонтиту порівняно зі здоровими людьми виявила, що вони були однаково підвищені (ОР=1,67, 95% ДІ=1,14-2,45; ОР=1,43, 95% ДІ=0,88-2,33; RR=1,22, 95% ДІ=0,74-2,01) [24].…”

Section: результати дослідження та їх обговоренняunclassified

Features of the Interrelationship of Periodontal Diseases and Somatic Diseases (Literature Review)

Vasko

Tkachenko

2023

Ukr. Dent. Alm.

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The interrelationship of periodontal diseases and somatic diseases has a two-way aggravating character. An analysis of modern scientific literature concerning the connection between periodontal diseases and systemic diseases of the human body has been realized. To collect information for this review, a search was conducted for the scientific literature presented in three databases (Pubmed, Scopus, Web of Science) for the past 2 years. Thirty-four studies, including reviews and original articles, were selected for qualitative analysis based on their relevance to the main content of this review. Numerous studies confirm the significant relationship between the severity of the course of oral inflammatory diseases, the state of its microbiome and the unfavorable prognosis of cardiovascular diseases, diseases of the respiratory system, metabolic syndrome, obesity, rheumatoid arthritis, etc. The presence of periodontitis in patients increases the risk of developing cardiovascular diseases, particularly coronary heart disease and stroke. A high prevalence of periodontal tissue diseases in people with chronic diseases of the digestive organs is noted, which is associated with a violation of all types of metabolism. Severe forms of periodontitis often coexist with diabetes of the first and second types and are considered the most frequent complications of diabetes. Recent studies have clearly substantiated the role of certain periodontal pathogenic microorganisms in the etiopathogenesis and complicated course of rheumatoid arthritis. Highly pathogenic microorganisms of the oral cavity, penetrating through the damaged epithelium of the vascular wall of the periodontal tissues into the systemic circulation, cause chronic bacteremia and affect distant organs and tissues. Since we cannot directly influence on the function of definite organs, it is advisable to prescribe not only basic periodontal treatment, but also the drugs that affect the vascular component of the inflammatory process, namely, strengthen the vascular wall and improve microcirculatory channel trophicity.

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“…Periodontitis is an infectious disease caused by plaque biofilm that leads to the destruction of toothsupporting tissues, with clinical symptoms including attachment loss, periodontal pocket formation, and alveolar bone resorption, which, if left untreated, can gradually lead to tooth loosening or even tooth loss (Petersen and Ogawa, 2012;Kinane et al, 2017;Van der Velden, 2017). There is a growing body of research showing that the health of oral tissues interacts with systemic health (Taylor et al, 2000;Genco and Sanz, 2020;Kapila, 2021;Larvin et al, 2022;Teles et al, 2022). Notably, periodontitis is closely associated with several systemic diseases, including atherosclerotic cardiovascular disease (Beck et al, 2001;Van Dyke et al, 2021;Isola et al, 2022), diabetes (Chapple et al, 2013;Genco and Borgnakke, 2020;Nibali et al, 2022), adverse pregnancy outcomes such as miscarriage and preterm delivery (Canakci et al, 2004;Sanz et al, 2013;Miranda-Rius et al, 2021), rheumatoid arthritis (Bartold and Lopez-Oliva, 2020;Möller et al, 2020;Gonzaĺez-Febles and Sanz, 2021), Alzheimer's disease (Pizza, 2019;Kamer et al, 2020;Torrealba-Garcıá et al, 2021) and inflammatory bowel disease (Cai et al, 2021;Imai et al, 2021;Zhang et al, 2021a;Baima et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

The effect of the “Oral-Gut” axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations

Zhou

Wang

et al. 2023

Front. Cell. Infect. Microbiol.

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Periodontitis and inflammatory bowel diseases (IBD) are inflammatory diseases of the gastrointestinal tract that share common features of microbial-induced ecological dysregulation and host immune inflammatory response. The close relationship between periodontitis and IBD is characterized by a higher prevalence of IBD in patients with periodontitis and a higher prevalence and severity of periodontitis in patients with IBD, indicating that periodontitis and IBD are different from the traditional independent diseases and form an “Oral-Gut” axis between the two, which affect each other and thus form a vicious circle. However, the specific mechanisms leading to the association between the two are not fully understood. In this article, we describe the interconnection between periodontitis and IBD in terms of microbial pathogenesis and immune dysregulation, including the ectopic colonization of the gut by pathogenic bacteria associated with periodontitis that promotes inflammation in the gut by activating the host immune response, and the alteration of the oral microbiota due to IBD that affects the periodontal inflammatory response. Among the microbial factors, pathogenic bacteria such as Klebsiella, Porphyromonas gingivalis and Fusobacterium nucleatum may act as the microbial bridge between periodontitis and IBD, while among the immune mechanisms, Th17 cell responses and the secreted pro-inflammatory factors IL-1β, IL-6 and TNF-α play a key role in the development of both diseases. This suggests that in future studies, we can look for targets in the “Oral-Gut” axis to control and intervene in periodontal inflammation by regulating periodontal or intestinal flora through immunological methods.

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Periodontitis and risk of immune‐mediated systemic conditions: A systematic review and meta‐analysis

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 17 publications

References 88 publications

Quercetin through miR-147–5p/Clip3 axis reducing Th17 cell differentiation to alleviate periodontitis

Quercetin through miR-147–5p/Clip3 axis reducing Th17 cell differentiation to alleviate periodontitis

Features of the Interrelationship of Periodontal Diseases and Somatic Diseases (Literature Review)

The effect of the “Oral-Gut” axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations

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