Periodontitis and Endothelial Dysfunction: Periodontal Clinical Parameters and Levels of Salivary Markers Interleukin‐1β, Tumor Necrosis Factor‐α, Matrix Metalloproteinase‐2, Tissue Inhibitor of Metalloproteinases‐2 Complex, and Nitric Oxide

Moura, Marcela Faria; Navarro, Túlio Pinho; Silva, Tarcı́lia Aparecida; Cota, Luís Otávio Miranda; Oliveira, Alcione Maria Soares Dutra; Costa, Fernando Oliveira

doi:10.1902/jop.2017.170023

Cited by 42 publications

(43 citation statements)

References 49 publications

(106 reference statements)

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“…Furthermore, higher NGAL levels in local samples, that is, gingival crevicular fluid (GCF), were reported in patients with periodontitis (Pradeep, Nagpal, Karvekar, & Patnaik, ). The present salivary NGAL data are therefore intriguing and warrant further study, but it is remarkable that conflicting data also exist for other salivary inflammatory markers in periodontitis, for example, with increased (Lee et al, ) or similar (Moura et al, ) salivary levels of IL‐1β compared to healthy controls. While the main contributor to salivary proteins is the circulation, with proteins shed from local oral surfaces playing a lesser role (Lynge Pedersen & Belstrom, ), disease‐specific mechanisms are likely to be involved, for example, with periodontitis‐dependent increased expression of inflammatory mediators in the inflamed oral tissue potentially being countered by increased local tissue binding or other interactions that contribute to unpredictability of salivary levels of these molecules.…”

Section: Discussionmentioning

confidence: 72%

Salivary microbiota and inflammation‐related proteins in patients with psoriasis

et al. 2020

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Objective The purpose of the present study was to characterize the composition of the salivary microbiota and quantify salivary levels of inflammation‐related proteins (neutrophil gelatinase‐associated lipocalin [NGAL] and transferrin) in patients with psoriasis and compare data to those obtained in patients with periodontitis and orally healthy controls, respectively. Materials and methods Stimulated saliva samples from patients with psoriasis (n = 27), patients with periodontitis (n = 58), and orally healthy controls (n = 52) were characterized by means of next‐generation sequencing of the 16S rRNA gene. Salivary levels of NGAL and transferrin were quantified using immunoassays. Results Linear discriminant effect size analysis showed that 52 (22 psoriasis‐associated and 30 periodontitis‐associated) and 21 (8 psoriasis‐associated and 13 orally healthy control‐associated) bacterial taxa differentiated the salivary microbiota in patients with psoriasis from that of patients with periodontitis and orally healthy controls, respectively. Significantly lower mean salivary levels of NGAL (psoriasis: 996 [std. error 320], periodontitis: 2,072 [295], orally healthy controls: 2,551 [345] ng/ml, p < .0001) and transferrin (psoriasis: 4.37 [0.92], periodontitis: 7.25 [0.88], orally healthy controls: 10.02 [0.94] ng/ml, p < .0001) were identified in patients with psoriasis. Conclusions Psoriasis associates with characteristics of the salivary microbiota and salivary levels of inflammation‐related proteins, which are different from characteristics in patients with periodontitis and orally healthy controls, respectively.

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Section: Discussionmentioning

confidence: 72%

Salivary microbiota and inflammation‐related proteins in patients with psoriasis

et al. 2020

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“…Periodontitis is known to be one of the main risk factors of several diseases, such as diabetes, CVD events, and endothelial dysfunction [27][28][29]. Moura et al [30] evaluated, in a cross-sectional study, 47 patients with and without periodontitis and found that patients with periodontitis presented a significantly higher endothelial dysfunction risk than individuals without periodontitis.…”

Section: Discussionmentioning

confidence: 99%

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Isola

Giudice

Alibrandi

et al. 2019

Genes

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The aim of the present study was to investigate the association and impact of periodontitis and tooth loss on a subtype of endothelial progenitor cell (EPC) levels (CD133+/KDR+). Furthermore, the objective was to determine if the periodontal status influenced CD133+/KDR+ levels. In all, 88 patients with periodontitis and 79 healthy controls (HCs) were enrolled in the study. Enrolled patients were examined and characterized by clinical and blood sample analysis. Spearman’s correlation test was applied in order to assess the interdependence between CD133+/KDR+ levels and all periodontal parameters. In order to estimate a statistically significant trend (p-trend) for ordered CD133++/KDR+ quartiles, the Jonckheere–Terpstra test was applied for all variables. Patients in the periodontitis group presented significantly lower CD133+/KDR+ levels (66.4 (45.5–269.6 cells/µL)) compared to the HC group (76.7 (24.3–313.2 cells/µL), p < 0.001). Lower CD133+/KDR+ levels negatively correlated with C-reactive protein (CRP), with the number of teeth, and with all periodontal parameters (p < 0.001). Moreover, there was a proportional increase in CD133+/KDR+ levels with a progressive increase in number of teeth (p-trend < 0.001), while there was a proportional decrease in CD133+/KDR+ levels with a proportional increase in clinical attachment level (CAL, p-trend = 0.003), probing depth (PD, p-trend = 0.007), and bleeding sites (bleeding on probing (BOP), p-trend < 0.001) as an extent measure of periodontitis. This study demonstrated that patients with periodontitis presented significantly lower CD133+/KDR+ levels compared to HCs. Moreover, all patients presented an increase in the CD133+/KDR+ EPC levels with an extended level of periodontitis and tooth loss.

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“…Main cell mediators are histamine, serotonin, eicosanoids, free radicals, cytokines, substance P, neurokinin, and enzymes involved in tissue destruction [13][14][15]. Bunte and Beikler recently reviewed periodontal immunity (2019) [16]. Briefly, the innate immune system activates phagocytosis, the complement system and the adaptative, immune system which is antigen-dependant and mediated by B and T cells.…”

Section: Introductionmentioning

confidence: 99%

Solidago virgaurea L. Plant Extract Targeted against Candida albicans to Reduce Oral Microbial Biomass: A Double Blind Randomized Trial on Healthy Adults

et al. 2020

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Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, Candida albicans. It reduces the biomass of Candida-bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group n = 33 vs. control n = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), C. albicans and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28 p = 0.005 and ΔD14D28 p = 0.026), Streptococcus mutans (ΔD0D14 p = 0.024) and C. albicans (ΔD0D28 p = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28 p = 0.062 and ΔD14D28 p = 0.009). Plaque Index and Gingival Index improved in both groups.

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Periodontitis and Endothelial Dysfunction: Periodontal Clinical Parameters and Levels of Salivary Markers Interleukin‐1β, Tumor Necrosis Factor‐α, Matrix Metalloproteinase‐2, Tissue Inhibitor of Metalloproteinases‐2 Complex, and Nitric Oxide

Abstract: Periodontitis was positively associated with ED, expressed by a smaller percentage of FMD of the brachial artery and higher salivary levels of MMP-2/TIMP-2 complex. Additionally, salivary levels of NO were significantly associated with better functioning of the vascular endothelium.

Cited by 42 publications

References 49 publications

Salivary microbiota and inflammation‐related proteins in patients with psoriasis

Salivary microbiota and inflammation‐related proteins in patients with psoriasis

Periodontitis and Tooth Loss Have Negative Systemic Impact on Circulating Progenitor Cell Levels: A Clinical Study

Solidago virgaurea L. Plant Extract Targeted against Candida albicans to Reduce Oral Microbial Biomass: A Double Blind Randomized Trial on Healthy Adults

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