The beneficial health effects of chlorogenic acids (CGAs), major components of coffee beans, are well known and have been attributed to multiple mechanisms of action. However, the lipolytic activity of CGAs does not appear to have been reported. We studied the effects of varying concentrations of Svetol®, a decaffeinated green coffee bean extract enriched in CGAs, on the liberation of free fatty acids from human adipocytes following short-term (2 h) and long-term (192 h) exposure. The results showed that although lipolytic activity observed following short-term incubation could be tentatively linked to residual caffeine traces in the sample, longer-term exposure clearly showed the effects of Svetol® on release of free fatty acids, and this effect was not due to caffeine. The results of this study provide a further mechanism by which to explain the long-term health benefits of CGAs and Svetol®.
Oxidation of lipids corresponds to the degradation of fatty acids by a continuation of sequential reactions : the decomposition of peroxides formed on the fatty chains after the attack by radicalaires compounds ends in the production of aldéhydes, cétones, acids, alcohols and go to a loss of the organoleptic and nutritional qualities (characteristic rancy smell and taste), thus a significant loss of economic value. The synthetic antioxidants (BHT, BHA) are effective, but their use is of pleased in more controversial. It is thus advisable to study with attention the plant natural antioxidants. The antioxidizing properties of the plant products are given by a certain number of tests as the test to the DPPH or the test ORAC in aqueous environment, and the measure of the index of peroxides or the Rancimat for the lipophilic phases. Certain tests are above all models of study, and few are really recognized, however certain standards are outlined, and the standardization arrives finally (cf the test ORAC, reference USDA). Among the compound vegetables which stand out very sharply at the level of their antioxidizing property, polyphénols are the most represented in the vegetal reign. It is a very wide family, but the extracts of grape seeds or tea are now well identified, and present results in the fight against the oxidation completely surprising.
Oral microbiome plays an important part on oral health and endogenous bacteria and fungi should not be eradicated. However, their proliferation must be controlled by oral hygiene care. In vitro, Solidago virgaurea ssp. virgaurea L. (SV) plant extract inhibits the adherence and hyphal formation of a fungus, Candida albicans. It reduces the biomass of Candida-bacterial biofilms but not fungal or bacterial growth. Unlike chemical antiseptics, like triclosan and chlorhexidine for instance, SV is a plant extract easily biodegradable. The purpose of this study was to assess the in vivo effectiveness of SV extract in reducing oral biomass. A randomized, double-blind clinical study, with dental plaque evaluation designed to assess the effectiveness of a fluorinated toothpaste containing SV (Bucovia™, Givaudan, Vernier, Switzerland) was conducted. Sixty-six subjects (SV group n = 33 vs. control n = 33) brushed their teeth twice a day for a 4-week period. Supragingival dental plaque was sampled. Total bacterial load (broad spectral bacterial quantitative Polymerase Chain Reaction (qPCR)), C. albicans and seven bacterial species were quantified by qPCR. In the Intervention group, there was a decrease of Total bacterial load (ΔD0D28 p = 0.005 and ΔD14D28 p = 0.026), Streptococcus mutans (ΔD0D14 p = 0.024) and C. albicans (ΔD0D28 p = 0.022). In the Control group Total bacterial load tended to decrease from baseline to day 28 (ΔD0D28 p = 0.062 and ΔD14D28 p = 0.009). Plaque Index and Gingival Index improved in both groups.
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