Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs

Saito, Akira; Saito, Emiko; Kuboki, Yoshinori; Kimura, M.; Nakajima, Toshinori; Yuge, Fumihiko; Kato, Tsuyoshi; Honma, Yoshiyuki; Takahashi, Tomomi; Ohata, Noboru

doi:10.4012/dmj.2012-171

Cited by 10 publications

(9 citation statements)

References 34 publications

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“…In the present study, the root surfaces in gelatin/β‐TCP/rhFGF‐2 sites exhibited greater amounts of new cementum with less epithelial down‐growth and connective tissue attachment when compared with the gelatin/β‐TCP sites. These results are consistent with previous animal studies that utilized HPC, nano‐β‐TCP/collagen, β‐TCP or a sandwich membrane composed of collagen sponge and gelatin microspheres as a carrier for rhFGF‐2 . rhFGF‐2 has been shown to stimulate the proliferation and migration of mesenchymal cells within the PDL while maintaining the multipotency of these cells, which later differentiate into cementoblasts, osteoblasts and collagen‐forming cells …”

Section: Discussionsupporting

confidence: 91%

Biodegradable gelatin/beta‐tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor‐2 for treatment of recession‐type defects: A split‐mouth study in dogs

Addin

Akizuki

Hoshi

et al. 2017

J of Periodontal Research

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Section: Discussionsupporting

confidence: 91%

Biodegradable gelatin/beta‐tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor‐2 for treatment of recession‐type defects: A split‐mouth study in dogs

Addin

Akizuki

Hoshi

et al. 2017

J of Periodontal Research

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“…In contrast, when applying recombinant human basic fibroblast growth factor plus gelatinous carrier in furcation Class II defects in Beagle dogs, significant periodontal regeneration was observed . Recently, it was shown that basic fibroblast growth factor, in combination with beta‐tricalcium phosphate, enhanced connective tissue attachement and bone formation to the fornix of Class III furcation defects in dogs . However, no published data on the application of basic fibroblast growth factor in human furcation lesions are available.…”

Section: Wound‐healing Studiesmentioning

confidence: 99%

Clinical concepts for regenerative therapy in furcations

Sanz¹,

Jepsen²,

Eickholz³

et al. 2015

Periodontology 2000

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Furcation involvements present one of the greatest challenges in periodontal therapy because furcation-involved molar teeth respond less favorably to conventional periodontal therapy compared with noninvolved molar or nonmolar teeth. Various regenerative procedures have been proposed and applied with the aim of eliminating the furcation defect or reducing the furcation depth. An abundance of studies and several systematic reviews have established the effectiveness of membrane therapy (guided tissue regeneration) for buccal Class II furcation involvement of mandibular and maxillary molars compared with open flap surgery. Bone grafts/substitutes may enhance the results of guided tissue regeneration. However, complete furcation closure is not a predictable outcome. Limited data and no meta-analyses are available on the effects of enamel matrix proteins for furcation regeneration. Enamel matrix protein therapy has demonstrated clinical improvements in the treatment of buccal Class II furcation defects in mandibular molars; however, complete closure of the furcation lesion is achieved only in a minority of cases. Neither guided tissue regeneration nor enamel matrix protein therapy have demonstrated predictable results for approximal Class II and for Class III furcations. Promising preclinical data from furcation regeneration studies in experimental animals is available for growth factor- and differentiation factor-based technologies, but very limited data are available from human clinical studies. Although cell-based therapies have received considerable attention in regenerative medicine, their experimental evaluation in the treatment of periodontal furcation lesions is at a very early stage of development. In summary, the indications and the limitations for currently available treatment modalities for furcation defects are well established. New regenerative treatments are clearly needed to improve the predictability of a complete resolution of furcation defects.

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“…In the present study ß-TCP was additionally added to create pores of different dimensions. ß-TCP is also widely used in regenerative therapy and tissue engineering [33][34][35][36][37]. Because of their osteoinductive characteristics calcium phosphate cements are therefore often applied [38].…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial photodynamic active biomaterials for periodontal regeneration

et al. 2018

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Both materials show excellent mechanical and cytocompatible properties. In addition, irradiation with 652nm induced significant bacterial suppression. The manufactured biomaterials might enable a more efficient cure of periodontal bone lesions. Due to the mechanical properties functional stability might be increased. Further, the materials are antimicrobial upon illumination with light that enables a trans-mucosal eradication of residual pathogens.

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Periodontal regeneration following application of basic fibroblast growth factor-2 in combination with beta tricalcium phosphate in class III furcation defects in dogs

Cited by 10 publications

References 34 publications

Biodegradable gelatin/beta‐tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor‐2 for treatment of recession‐type defects: A split‐mouth study in dogs

Biodegradable gelatin/beta‐tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor‐2 for treatment of recession‐type defects: A split‐mouth study in dogs

Clinical concepts for regenerative therapy in furcations

Antimicrobial photodynamic active biomaterials for periodontal regeneration

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