Antimicrobial photodynamic active biomaterials for periodontal regeneration

Sigusch, Bernd W.; Dietsch, S.; Berg, Albrecht; Voelpel, Andrea; Guellmar, André; Rabe, U.; Schnabelrauch, Matthias; Steen, Dorika; Gitter, Burkhard; Albrecht, Volker; Watts, David C.; Kranz, Stefan

doi:10.1016/j.dental.2018.06.026

Cited by 15 publications

(17 citation statements)

References 53 publications

(57 reference statements)

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“…The antibacterial action can reduce the corrosion of the tooth surface by bacteria and prolong the service life of teeth, which is an important parameter index for oral materials. , Antimicrobial assay experimental results are shown in panels b and c of Figure . For our samples, a pronounced antibacterial effect was detected in S.…”

Section: Resultsmentioning

confidence: 99%

Photochemically Driven Polymeric Biocompatible and Antimicrobial Thiol–Acrylate Nanocomposite Suitable for Dental Restoration

Zhou

Zhao

et al. 2022

ACS Appl. Mater. Interfaces

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The development a photochemically driven polymeric composite for dental restorative materials to restore tooth cavities with antibacterial, biocompatibility, and outstanding mechanical properties is an urgent need for clinical application in stomatology. Herein, a series of polyurethane acrylate (PUA) prepolymers and antibacterial polyurethane acrylate quaternary ammonium salts (PUAQASs) were synthesized, and their mechanical and biological properties were explored. The unique secondary mercaptan with a long shelf life and low odor was used to reduce oxygen inhibition and increase cross-linking density; meanwhile, modified photocurable nano zirconia (nano ZrO 2 ) enhances mechanical properties of the nanocomposites and possesses preeminent dispersion in the matrix. The results show that minimal inhibitory concentrations (MICs) of PUAQASs are 200 and 800 μg/mL for Staphylococcus aureus and Escherichia coli, respectively. The addition of secondary thiols significantly increases the photopolymerization rate and monomer conversion. The highest hardness and modulus reach 1.8 and 8.7 GPa compared to 1.8 and 8.3 GPa for commercial resin. The lap shear stress on the pig bone is 912 MPa, and that on commercial resin is 921 MPa. Most importantly, the photochemically driven polymeric composite has excellent biocompatibility and significantly better antimicrobial properties than commonly used commercial resins.

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Section: Resultsmentioning

confidence: 99%

Photochemically Driven Polymeric Biocompatible and Antimicrobial Thiol–Acrylate Nanocomposite Suitable for Dental Restoration

Zhou

Zhao

et al. 2022

ACS Appl. Mater. Interfaces

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“…Photoresponsive coatings, inks, and adhesives are also useful in large surface area applications . Biomaterials incorporating phototunable polymer matrices that define small areas have found utility in surgery or dental restoration . In this work, a novel photosensitive polymer responsive to ultraviolet (UV) 200–450 nm, extreme ultraviolet (EUV) 13.5 nm, or 50 keV electron beam (EB) radiation is described.…”

Section: Methodsmentioning

confidence: 99%

Photosensitive Hypervalent Fluorinated Sulfur Containing Polymers for Light Sensitive Applications

Bonetti

Murphy

Brainard

et al. 2020

Journal of Polymer Science

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Photochemical initiation of polymerization by visible or broadband ultraviolet irradiation of a mixture of 1,4‐(bis‐chlorotetrafluoro‐λ6‐sulfanyl) benzene and 1,4‐diethynyl benzene forms light responsive polymers. The novel polymers have a trans‐tetrafluoro‐λ6‐sulfanyl (tetrafluorosulfanyl, SF4) group backbone and are sensitive to electron beam (EB) and extreme ultraviolet (EUV) irradiation. Both EB lithography and EUV contrast experiments demonstrate the sensitivity of the polymer films to short wavelength irradiation.

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“…Furthermore, when the light dose was increased to 54 and 108 J·cm −2 , A. actinomycetemcomitans and P. gingivalis biofilms were completely eradicated, respectively [165]. Regarding periodontal regeneration, two in-situ curable biomaterials, BioM1 and BioM2, were developed as support for PS and had excellent mechanical and antimicrobial behaviors [15]. The BioM1 and BioM2 consisted of urethane dimethacrylate and a tri-armed oligoester-urethane methacrylate, respectively.…”

Section: Polymeric Materials For Antibacterial Photodynamic Therapmentioning

confidence: 99%

“…The PS was composed of a mixture of β-tricalcium phosphate (β-TCP) microparticles and 20 wt % photosensitizer mTHPC (Figure 7B). The BioM2 + PS with a single laser-illumination (652 nm) caused total suppression of P. gingivalis , while BioM2 + PS with repeated irradiation reduced 3.1 log in CFU counts [15].…”

Section: Polymeric Materials For Antibacterial Photodynamic Therapmentioning

confidence: 99%

“…Second, polymeric materials can serve as intra-pocket drug delivery devices for the treatment of periodontitis in various formulations and forms. Third, polymeric materials can be applied in fabrication of biodegradable periodontal membranes for guided tissue regeneration (GTR) [12,13,14,15,16]. The periodontal membrane acts as a mechanical barrier which protects the clot, and allows periodontal ligament and bone tissue to selectively repopulate the root surface during healing [12].…”

Section: Introductionmentioning

confidence: 99%

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Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms

Chi

et al. 2019

IJMS

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Periodontitis is a common infectious disease characterized by loss of tooth-supporting structures, which eventually leads to tooth loss. The heavy burden of periodontal disease and its negative consequence on the patient’s quality of life indicate a strong need for developing effective therapies. According to the World Health Organization, 10–15% of the global population suffers from severe periodontitis. Advances in understanding the etiology, epidemiology and microbiology of periodontal pocket flora have called for antibacterial therapeutic strategies for periodontitis treatment. Currently, antimicrobial strategies combining with polymer science have attracted tremendous interest in the last decade. This review focuses on the state of the art of antibacterial polymer application against periodontal pathogens and biofilms. The first part focuses on the different polymeric materials serving as antibacterial agents, drug carriers and periodontal barrier membranes to inhibit periodontal pathogens. The second part reviews cutting-edge research on the synthesis and evaluation of a new generation of bioactive dental polymers for Class-V restorations with therapeutic effects. They possess antibacterial, acid-reduction, protein-repellent, and remineralization capabilities. In addition, the antibacterial photodynamic therapy with polymeric materials against periodontal pathogens and biofilms is also briefly described in the third part. These novel bioactive and therapeutic polymeric materials and treatment methods have great potential to inhibit periodontitis and protect tooth structures.

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Antimicrobial photodynamic active biomaterials for periodontal regeneration

Cited by 15 publications

References 53 publications

Photochemically Driven Polymeric Biocompatible and Antimicrobial Thiol–Acrylate Nanocomposite Suitable for Dental Restoration

Photochemically Driven Polymeric Biocompatible and Antimicrobial Thiol–Acrylate Nanocomposite Suitable for Dental Restoration

Photosensitive Hypervalent Fluorinated Sulfur Containing Polymers for Light Sensitive Applications

Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms

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