Periodontal Ligament Remodeling and Alveolar Bone Resorption During Orthodontic Tooth Movement in Rats with Diabetes

Li, Xin; Zhang, Lin; Wang, Na; Feng, Xing; Bi, Liangjia

doi:10.1089/dia.2009.0085

Cited by 35 publications

(63 citation statements)

References 39 publications

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“…Some previous studies indicated a decrease in the number of osteoclasts in type 1 diabetic rodent (20)(21)(22). On the other hand, several groups have reported higher levels of TRAP activity and an increased number of osteoclasts was observed in type 1 diabetic rodent (23)(24)(25)(26). In this regard, this study aimed to investigate the potential effect of insulin on RANKL and OPG expression in osteoblasts for the purpose of investigating the effect of insulin on osteoclast differentiation.…”

Section: Discussionmentioning

confidence: 96%

Insulin effect on RANKL and OPG expression in human osteoblast-like MG63 cells

Wang¹,

Zhong²

2013

Turk J Med Sci

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A simple method for simultaneous pre-concentration of Cu, Ni, and Co metal ions prior to their determination by flame atomic absorption spectrometry is reported. The method is based on the extraction of target ions via complexation with indane-1,2,3-trione 1,2-dioxime immobilized on sodium dodecyl sulfate (SDS) coated alumina. The metal content on the adsorbent was eluted with 4.5 mL of 2 mol L −1 nitric acid. The influences of the analytical parameters including pH, sample volume and flow rate, and eluent type and flow rate were investigated. The effect of matrix ions on the retentions of the analytes was also examined. The recoveries of analytes were generally higher than 96% with a low relative standard deviation (R.S.D. < 3%). The presented method was successfully applied for determination of these metals in water samples.

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Section: Discussionmentioning

confidence: 96%

Insulin effect on RANKL and OPG expression in human osteoblast-like MG63 cells

Wang¹,

Zhong²

2013

Turk J Med Sci

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“…19 Rapid bone resorption and marked PDL destruction are features of orthodontic movement in animal models of diabetes in a study done by Li et al, 2 with significantly more osteoclasts in the PDL of diabetic induced rats compared with normoglycemic rats after orthodontic treatment. Graber et al 20 stated that TNF-α plays a prominent role in the mechanism controlling the appearance of osteoclasts at compression sites.…”

Section: Discussionmentioning

confidence: 99%

“…1 The change in the metabolic state interferes with bone remodelling and results in a different rate of tooth movement. 2 Braga et al 3 reported greater tooth movement with retarded osseous regeneration, debilitation of the periodontal ligament, and microangiopathies in diabetic experimental mice when compared with the normal group. Diabetes affects the periodontium through cytokine dysregulation, where poor glycemic control is significantly correlated with the greater production of cytokines and higher cytokine levels in gingival fluid.…”

Section: Introductionmentioning

confidence: 99%

Effects of infliximab local injection on orthodontic tooth movement in diabetic rabbits: A histological study

Mudhir

Al-Maroof

Jasim

2016

ZJMS

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“…In diabetes condition, there is an increased production of AGEs (advanced glycation end products), ROS (reactive oxygen species) and TNF, which affects the development of periodontal disease [8]. Volume Metabolic changes (such as diabetes) can interfere with bone remodeling that can lead to differences in the rate of tooth movement [9,10]. Diabetes affects osteoblasts, fibroblasts, and collagen expression, through the process of inflammation and apoptosis [8].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Different Orthodontic Force on MMP 9 Expression in a Rat Diabetic Model

Maulana¹,

Hikmah²,

Shita³

et al. 2014

JTLS

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Orthodontic forces produce alveolar bone and periodontal ligament remodeling that cause tooth movement. Diabetes can increase tissue damage and, therefore, contributes to the process of orthodontic tooth movement. The aim of this study was to determine the effect of differently orthodontic forces on the expression of MMP nine in rat diabetic model. Twenty four male Wistar rats were divided into three groups of control and three groups of treatment strept ozotocin-induced diabetes with stratified doses. Application of orthodontic appliance was performed with different forces (10, 20 and 30 grF). Orthodontic appliance was performed on both upper incisors. Immunohistochemical (IHC) analysis was used to observe the expression of MMP 9 and HE (Hematoxylen Eosin) staining to observe the number of fibroblasts. Statistical analysis was carried out using t -test and Spearman correlation analysis to determine the difference of MMP nine expression and number of fibroblasts between groups, and determine the correlation of both. The results showed an increased expression of MMP 9 and decreased of fibroblasts number in diabetic rats, along with increasing magnitude of orthodontic forces. The different orthodontic forces given to diabetic rats affect the expression of MMP 9 and the number of fibroblasts, in which the expression of MMP 9 increased along with the increase of orthodontic forces, both at pressure and tension sides..

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Periodontal Ligament Remodeling and Alveolar Bone Resorption During Orthodontic Tooth Movement in Rats with Diabetes

Abstract: Under mechanical forces, diabetes prolonged duration of degradation of PDL and remodeling of PDL and resorption of alveolar bone.

Cited by 35 publications

References 39 publications

Insulin effect on RANKL and OPG expression in human osteoblast-like MG63 cells

Insulin effect on RANKL and OPG expression in human osteoblast-like MG63 cells

Effects of infliximab local injection on orthodontic tooth movement in diabetic rabbits: A histological study

The Effect of Different Orthodontic Force on MMP 9 Expression in a Rat Diabetic Model

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