Periodontal disease as a non-traditional risk factor for acute coronary syndrome: a systematic review and meta-analysis

Meregildo-Rodríguez, Edinson Dante; Robles-Arce, Luis Gianmarco; Chunga-Chévez, Eleodoro Vladimir; Asmat-Rubio, Martha Genara; Zavaleta-Alaya, Petterson; Vásquez-Tirado, Gustavo Adolfo

doi:10.53854/liim-3004-4

Cited by 3 publications

(2 citation statements)

References 66 publications

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“…The potential impact of periodontal infection on cardiovascular diseases has been the subject of much research [ 97 , 98 ]. Teles et al undertook the challenge of explaining possible associations with an increased risk of cardiovascular diseases and periodontal disorders.…”

Section: Oral Microbiome In Systemic Diseasesmentioning

confidence: 99%

The Role of the Oral Microbiome in the Development of Diseases

Kozak

Pawlik

2023

IJMS

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Periodontal disease (PD) is a complex and infectious illness that begins with a disruption of bacterial homeostasis. This disease induces a host inflammatory response, leading to damage of the soft and connective tooth-supporting tissues. Moreover, in advanced cases, it can contribute to tooth loss. The aetiological factors of PDs have been widely researched, but the pathogenesis of PD has still not been totally clarified. There are a number of factors that have an effect on the aetiology and pathogenesis of PD. It is purported that microbiological, genetic susceptibility and lifestyle can determine the development and severity of the disease. The human body’s defence response to the accumulation of plaque and its enzymes is known to be a major factor for PD. The oral cavity is colonised by a characteristic and complex microbiota that grows as diverse biofilms on all mucosal and dental surfaces. The aim of this review was to provide the latest updates in the literature regarding still-existing problems with PD and to highlight the role of the oral microbiome in periodontal health and disease. Better awareness and knowledge of the causes of dysbiosis, environmental risk factors and periodontal therapy can reduce the growing worldwide prevalence of PDs. The promotion of good oral hygiene, limiting smoking, alcohol consumption and exposure to stress and comprehensive treatment to decrease the pathogenicity of oral biofilm can help reduce PD as well as other diseases. Evidence linking disorders of the oral microbiome to various systemic diseases has increased the understanding of the importance of the oral microbiome in regulating many processes in the human body and, thus, its impact on the development of many diseases.

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Section: Oral Microbiome In Systemic Diseasesmentioning

confidence: 99%

The Role of the Oral Microbiome in the Development of Diseases

Kozak

Pawlik

2023

IJMS

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“…It is estimated that 17.9 million people died from cardiovascular disease, heart attacks, and strokes in 2019 [2]. Several risk factors contribute to the development of coronary atherosclerosis, including diabetes mellitus, hypertension, smoking, a diet high in saturated fat, a lack of exercise, inflammatory factors [3], endothelial progenitor cells (EPCs) [4], and chronic periodontitis [5].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the Effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C Gene Polymorphisms; IL-6 Levels; and CRP Levels on Chronic Periodontitis in Coronary Artery Disease in Indonesia

Sitompul

Pikir

Aryati

et al. 2023

Genes

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Interleukin 6 (IL-6) and C-Reactive Protein (CRP) play an important role in chronic periodontitis with coronary artery disease (CAD). Genetic factors can affect a person’s risk of CAD, which affects one-third of the population. This study investigated the role of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms. IL-6 and CRP levels on the severity of periodontitis in CAD in Indonesia were also evaluated. This case-control study was conducted with mild and moderate–severe chronic periodontitis groups. A path analysis test was conducted with Smart PLS with a 95% confidence interval to determine the significant variable for chronic periodontitis. Our study revealed that the effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms on IL-6 levels and CRP levels were not significant. IL-6 and CRP levels were not significantly different between the two groups. We found that IL-6 levels had a significant effect on CRP levels in periodontitis patients with CAD (path coefficient 0.322, p = 0.003). IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C gene polymorphisms had no effect on the severity of chronic periodontitis in CAD patients in the Indonesian population. We also observed no apparent effects of the influence of gene polymorphisms in IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C genes. Although the IL-6 and CRP levels were not significantly different between the two groups, IL-6 levels affected CRP levels in periodontitis patients with CAD.

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Features of the Interrelationship of Periodontal Diseases and Somatic Diseases (Literature Review)

Vasko

Tkachenko

2023

Ukr. Dent. Alm.

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The interrelationship of periodontal diseases and somatic diseases has a two-way aggravating character. An analysis of modern scientific literature concerning the connection between periodontal diseases and systemic diseases of the human body has been realized. To collect information for this review, a search was conducted for the scientific literature presented in three databases (Pubmed, Scopus, Web of Science) for the past 2 years. Thirty-four studies, including reviews and original articles, were selected for qualitative analysis based on their relevance to the main content of this review. Numerous studies confirm the significant relationship between the severity of the course of oral inflammatory diseases, the state of its microbiome and the unfavorable prognosis of cardiovascular diseases, diseases of the respiratory system, metabolic syndrome, obesity, rheumatoid arthritis, etc. The presence of periodontitis in patients increases the risk of developing cardiovascular diseases, particularly coronary heart disease and stroke. A high prevalence of periodontal tissue diseases in people with chronic diseases of the digestive organs is noted, which is associated with a violation of all types of metabolism. Severe forms of periodontitis often coexist with diabetes of the first and second types and are considered the most frequent complications of diabetes. Recent studies have clearly substantiated the role of certain periodontal pathogenic microorganisms in the etiopathogenesis and complicated course of rheumatoid arthritis. Highly pathogenic microorganisms of the oral cavity, penetrating through the damaged epithelium of the vascular wall of the periodontal tissues into the systemic circulation, cause chronic bacteremia and affect distant organs and tissues. Since we cannot directly influence on the function of definite organs, it is advisable to prescribe not only basic periodontal treatment, but also the drugs that affect the vascular component of the inflammatory process, namely, strengthen the vascular wall and improve microcirculatory channel trophicity.

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Periodontal disease as a non-traditional risk factor for acute coronary syndrome: a systematic review and meta-analysis

Cited by 3 publications

References 66 publications

The Role of the Oral Microbiome in the Development of Diseases

The Role of the Oral Microbiome in the Development of Diseases

Analysis of the Effects of IL-6 -572 C/G, CRP -757 A/G, and CRP -717 T/C Gene Polymorphisms; IL-6 Levels; and CRP Levels on Chronic Periodontitis in Coronary Artery Disease in Indonesia

Features of the Interrelationship of Periodontal Diseases and Somatic Diseases (Literature Review)

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