Periodontal Disease and Incident Lung Cancer Risk: A Meta‐Analysis of Cohort Studies

Abstract

Evidence from cohort studies suggests that patients with periodontal disease are at increased risk of developing lung cancer.

Tumor Targeting by Fusobacterium nucleatum: A Pilot Study and Future Perspectives

“…This raise in bacterial numbers together with the frequent bleeding of the gums during periodontitis, increases the probability of hematogenous translocation of oral bacteria to distant tumors. Indeed, as part of the growing interest in the effect of oral health on general health (Pihlstrom et al, 2005; Rautemaa et al, 2007), the relationship between periodontitis and cancer development is of growing interest (Hiraki et al, 2008; Zeng et al, 2016). …”

Microbiota dysbiosis in select human cancers: Evidence of association and causality

“…Smoking is a well-known risk factor for lung cancer due to its carcinogenic chemical components (89). Emerging studies suggest that multiple additional factors, including systemic inflammatory responses (90), infections with certain microorganisms (91–95) and periodontal diseases (33, 96, 97) contribute to lung cancer development.…”

“…Research during the past ten years has consistently shown that periodontal diseases, known to alter the oral microbiota, are associated with lung cancer risk (33, 96, 97), but most of the previous studies failed to exclude the role of confounding factors like smoking (97). One recent study (65) indicated that advanced periodontitis was associated with a 2.5-fold increase in lung cancer among people who never smoked.…”

“…One recent study (65) indicated that advanced periodontitis was associated with a 2.5-fold increase in lung cancer among people who never smoked. Periodontitis-related lung cancer has been proposed to result from inflammatory immune responses initiated in the oral cavity that modify the respiratory epithelium and promote carcinogenesis (96), but the responsive immune cell populations and cytokines involved in the biological mechanisms remain undetermined. Limited preliminary data propose a few transcriptomic salivary biomarkers, relating to growth regulation and tumor suppressor genes, as possibly useful to discriminate lung cancer from health (98), but prospective longitudinal data are needed.…”

Periodontitis as a risk factor for lung cancer among women: A nationwide matched cohort study

“…2 Several studies reported that periodontitis might be associated with lung cancer and that the association remained significant in women. 3,4 However, there still lack large-scale studies and subgroup analyses to fully understand the association between periodontitis and lung cancer among women.…”