Evidence from cohort studies suggests that patients with periodontal disease are at increased risk of developing lung cancer.

Background: A new type of coronavirus, novel coronavirus , is causing an increasing number of cases of pneumonia and was declared a Public Health Emergency of International Concern by the World Health Organization on 30 January 2020. The virus first appeared in Wuhan, China, in late December 2019, and traditional Chinese herbal medicine is being used for its treatment. This systematic review and meta-analysis will assess studies of the effects of traditional Chinese herbal medicine in COVID-19 pneumonia.Methods: We will search electronic databases including PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), and Wanfang database using keywords related to COVID-19 and traditional Chinese herbal medicine. Reference lists of relevant trials and reviews will be searched. We will manually search gray literature, such as conference proceedings and academic degree dissertations, and trial registries. Two independent reviewers will screen studies (XL and DZ), extract data (YL and LG), and evaluate risk of bias (YL and DZ). Data analysis will be conducted using the Review Manager software (version 5.3.5) and R software (version 3.6.1). Statistical heterogeneity will be assessed using a standard chi-square test with a significance level of P < 0.10. Biases associated with study size (e.g., publication bias) will be investigated using funnel plots, Egger's test and Begg's test, and Trim and Fill analysis.Discussion: This study will provide a high-quality synthesis of the effects of traditional Chinese herbal medicine for COVID-19. The use of traditional Chinese herbal medicine for treatment or prevention of these novel viral infections affecting the pneumonia will be investigated. Systematic review registration: PROSPERO registration number: CRD42020168004

Objective: The objective of this study was to analyze the 100 most cited studies on vaccine. Methods: A comprehensive search of studies on vaccine was performed in the Web of Science Core Collection without year or language restrictions. The 100 top-cited studies were retrieved after screening abstracts or full-texts. The outcomes of bibliometric analysis included citation time, citation density, journal name, impact factor, publication year, article type, category, open access, and country of origin. Results: The citation times for the 100 top-cited studies ranged from 593 to 2406, with a median citation times of 834. The 100 top-cited studies were published in 32 journals, and the journal with the most studies was New England Journal of Medicine (n = 20). They were published between 1969 and 2012, and 4 authors published at least 2 studies as the first author. The USA contributed the most studies (n = 70), followed by Switzerland (n = 4), England (n = 4) and Finland (n = 4). Eighty-one studies were published as Article, while 19 were Review. Eleven studies were about vaccine for therapeutic and 68 studies were about vaccine for prophylactic. Conclusions: This is the first bibliometric analysis to provide a detailed list of the 100 most-cited studies on vaccine and helps to recognize the quality of the works, discoveries, and trends in the field.

Background Compassion fatigue is described as the phenomenon of exhaustion and dysfunction in healthcare workers resulting from prolonged exposure to work‐related stress and compassion stress. Oncology nurses are at high risk for compassion fatigue. Aims Our study aims to estimate the levels, prevalence and related factors of compassion fatigue dimension in oncology nurses. Design Systematic review and meta‐analysis. Method Ten electronic databases were conducted in the systematic review and meta‐analysis. Time frame of the searches is from inception up to 31 January 2020. The research team independently conducted study selection, quality assessments, data extractions and analysis of all included studies. The means, standard deviations and prevalence of three dimensions of compassion fatigue were pooled using random‐effects meta‐analysis. The PRISMA guideline was used to report the systematic review and meta‐analysis. PROSPERO registration number: CRD42020205521. Results The systematic review included 21 studies, involving 6533 oncology nurses across 6 different countries. In our studies, the pooled mean scores of compassion satisfaction (CS), burnout (BO) and secondary traumatic stress (STS) were 35.47 (95% CI: 33.54–37.41), 24.94 (95% CI: 23.47–26.41) and 24.48 (95% CI: 23.36–25.60), respectively; the pooled prevalence of “low” rates of CS, “high” rates of BO and STS were 20% (CI 13%–28%), 22% (CI 18%–26%) and 22% (CI 17%–28%), respectively; furthermore, geographical regions (Asia) significantly affect the prevalence of compassion fatigue among oncology nurses. The compassion fatigue variables considered were demographic (age, marital status, education background, health condition and gender), work‐related (job satisfaction, income satisfaction, years of working experience, professional title, position and work environment) and other variables (social support, coping strategy, self‐compassion, professional cognition and psychological training). Conclusion Oncology nurses were at “moderate” level of compassion satisfaction, burnout and secondary traumatic stress, and 22% of oncology nurses suffered from “high” risk of compassion fatigue. Hospital administrators should develop interventions to address compassion fatigue phenomenon, and enhance the mental health of oncology nurses and nursing care results. Relevance to clinical practice Oncology unit warrants special attention, and oncology nurses are at high risk for compassion fatigue. However, the reported prevalence rates and oncology nurses with different characteristics vary considerably. The review provides a preliminary framework for nursing administrators to develop interventions to address compassion fatigue phenomenon, and enhance the psychological health of oncology nurses.

Background and objective Platelet‐to‐lymphocyte ratio (PLR) has been suggested to be associated with the progression of oral cancer with inconclusive results. The objective of the current study was to assess the prognostic role of oral cancer by meta‐analysis. Method PubMed, EMbase(Ovid), CNKI, WanFang Data, VIP, and CBM databases were searched up to August 24, 2018. Studies investigating the association between PLR and progression of oral cancer were included. Meta‐analysis was performed by using Revman 5.3 software. The protocol of the study was registered on PROSPERO (CRD42018106836). Results A total of five studies were included in the meta‐analysis. The results of the meta‐analysis showed that higher PLR was associated with the poor progress of oral cancer (overall survival: OR = 2.06, 95 CI: 1.49‐2.86, P < 0.0001; disease‐specific survival: OR = 2.12, 95 CI: 1.59‐2.82, P < 0.00001). Conclusion The current meta‐analysis showed that higher PLR is a poor progression factor for oral cancer. However, larger sample, multi‐center studies should be carried out in the future to validate the above conclusion.