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Based on our clinical experience and after a thorough literature review, we propose that ultrasound-guided intranodal lymphangiography with contrast agent could be considered a viable therapeutic option for persistent chylous leakages in selected patients.

C6orf141 (Chromosome 6 open reading frame 141) is a novel gene, and its role in oral cancer progression remains unclear. C6orf141 expression in oral squamous cell carcinoma (OSCC) and adjacent normal tissues from 428 patients was examined through immunohistochemistry (IHC). Our results revealed that C6orf141 expression was significantly reduced in OSCC compared with adjacent normal tissues. Low C6orf141 expression was significantly associated with a poor American Joint Committee on Cancer pathological stage (P < 0.001), T classification (P = 0.002), and pN stage (P = 0.032). Kaplan–Meier curves revealed that low C6orf141 expression was significantly associated with shorter disease-specific survival (DSS) in patients with OSCC (log-rank P = 0.007). Multivariate analysis indicated that low C6orf141 expression was an independent prognostic biomarker for DSS (adjusted hazard ratio = 1.34; 95% confidence interval = 1.10–1.81; P = 0.05). Additionally, ectopic C6orf141 expression could significantly suppress oral cancer cell proliferation, colony formation, and migratory and invasive abilities. Xenograft tumor growth assay revealed that C6orf141 could significantly suppress oral tumor growth in vivo. Our results suggest that C6orf141 plays a novel tumor-suppressive role in oral cancer cell growth and motility. Furthermore, C6orf141 dysfunction could be a potential prognostic biomarker for OSCC and provide new therapeutic strategies in the future.

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Background/purpose In a previous fractural study of implant-supported crowns, it was found that the palladium−silver crowns possessed the highest fracture force. The ceramic–metal interface was examined to explain its high resistance to fracture. Materials and methods Palladium−silver crowns with the morphology of a maxillary second premolar were prepared following standard dental laboratory procedures. Crown specimens were compressed vertically in the center of the occlusal surface until fracture, using a universal testing machine. The fractured surfaces were examined using scanning electron microscopy combined with energy dispersive X-ray spectroscopy to determine the failure mode. The ceramic–metal interface of the crown was examined with electron probe microanalysis. Additionally, sheet specimens with a dimension of 10 × 9 × 4 mm 3 were prepared to examine the surface morphology and composition of palladium−silver alloy after oxidation and porcelain-fused-to-metal firing cycles. Results The average fracture force was 1425 ± 392N. Analyses with scanning electron microscopy combined with energy dispersive X-ray spectroscopy revealed that the failure mode was cohesive within the ceramic layer. Electron probe microanalysis micrographs indicated that Sn and In were found to distribute only on the alloy side of the ceramometal crown. Energy dispersive X-ray spectroscopy analysis and electron probe microanalysis micrographs confirmed that ZnO had diffused into the ceramic phase. Conclusion In 2 O 3 , SnO 2 , and ZnO were found along the interface; the presence of these oxides at the boundary promotes ceramic–metal adhesion, and this resulted in cohesive failure of the ceramic layer. ZnO was found to diffuse into the ceramic phase, and it is suggested to be beneficial for high fracture resistance in the present study.

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