Periodontal clinical and microbiological characteristics in healthy <i>versus</i> generalized aggressive periodontitis families

Monteiro, Mabelle Freitas; Casati, Márcio Zaffalon; Taiete, Tiago; Vale, Hugo Felipe do; Nociti, Francisco Humberto; Sallum, Enílson Antônio; Silvério, Karina Gonzáles; Casarin, Renato Corrêa Viana

doi:10.1111/jcpe.12459

Cited by 24 publications

(21 citation statements)

References 34 publications

(50 reference statements)

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“…Nodes with top ten connectivity are labeled by the taxon name prevalence). [49][50][51] However, our results are consistent with those studies carried out in Asian populations. 27,[52][53][54] This discrepancy might due to different ethnicities as concluded by most researchers.…”

supporting

confidence: 92%

Measuring the subgingival microbiota in periodontitis patients: Comparison of the surface layer and the underlying layers

Liu

Chen

Cai

et al. 2019

Microbiology and Immunology

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Periodontitis is a major cause of tooth loss in adults that initially results from dental plaque. Subgingival plaque pathogenesis is affected by both community composition and plaque structures, although limited data are available concerning the latter. To bridge this knowledge gap, subgingival plaques were obtained using filter paper (the fourth layer) and curette (the first-third layers) sequentially and the phylogenetic differences between the first-third layers and the fourth layer were characterized by sequencing the V3-V4 regions of 16S rRNA. A total of 11 phyla, 148 genera, and 308 species were obtained by bioinformatic analysis, and no significant differences between the operational taxonomic unit numbers were observed for these groups. In both groups, the most abundant species were Porphyromonas gingivalis and Fusobacterium nucleatum. Actinomyces naeslundii, Streptococcus intermedius, and Prevotella intermedia possessed relatively high proportions in the first-third layers; while in the fourth layer, both traditional pathogens (Treponema denticola and Campylobacter rectus) and novel pathobionts (Eubacterium saphenum, Filifactor alocis, Treponema sp. HOT238) were prominent. Network analysis showed that either of them exhibited a scale-free property and was constructed by two negatively correlated components (the pathogen component and the nonpathogen component), while the synergy in the nonpathogen component was lower in the first-third layers than that in the fourth layer. After merging these two parts into a whole plaque group, the negative/positive correlation ratio increased. With potential connections, the first-third layers and the fourth layer showed characteristic key nodes in bacterial networks. K E Y W O R D Speriodontitis, plaque layers, sequencing, subgingival microbiota Abbreviations: ANCOVA, analysis of covariance; ANOSIM, analysis of the similarities; BI, bleeding index; CAL, clinical attachment loss; FISH, fluorescent in situ hybridization; LDA, linear discriminant analysis; LEfSe, linear discriminant analysis effect size; OTU, operational taxonomic unit; PCoA, principal coordinate analysis; PD, probing depth; PlI, plaque index.

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supporting

confidence: 92%

Measuring the subgingival microbiota in periodontitis patients: Comparison of the surface layer and the underlying layers

Liu

Chen

Cai

et al. 2019

Microbiology and Immunology

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“…Monteiro et al. () and Hughes et al. () reported a mean PPD of 2.7 and 2.98 mm, respectively, while Haas et al.…”

Section: Discussionmentioning

confidence: 94%

Tooth loss and alveolar bone crest loss during supportive periodontal therapy in patients with generalized aggressive periodontitis: retrospective study with follow‐up of 8 to 15 years

Díaz‐Faes

Guerrero²,

Magán‐Fernández

et al. 2016

J Clinic Periodontology

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“…, Monteiro et al. , Li et al., ; Feng et al., ). Some putative pathogens, such as F. alocis and Selenomonas , were also found to have high prevalences and abundances in our study, which was consistent with similar open‐ended method studies in patients with AgP (Faveri et al.…”

Section: Discussionmentioning

confidence: 99%

Shift in the subgingival microbiome following scaling and root planing in generalized aggressive periodontitis

Liu

Luan

Chen

et al. 2018

J Clinic Periodontology

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Periodontal clinical and microbiological characteristics in healthy versus generalized aggressive periodontitis families

Abstract: Children from GAP families have worst clinical conditions, i.e. higher levels of PI, GI, and PPD, a more pathogenic microbiological profile, and the amount of Aa are associated with a higher marginal inflammation.

Cited by 24 publications

References 34 publications

Measuring the subgingival microbiota in periodontitis patients: Comparison of the surface layer and the underlying layers

Measuring the subgingival microbiota in periodontitis patients: Comparison of the surface layer and the underlying layers

Tooth loss and alveolar bone crest loss during supportive periodontal therapy in patients with generalized aggressive periodontitis: retrospective study with follow‐up of 8 to 15 years

Shift in the subgingival microbiome following scaling and root planing in generalized aggressive periodontitis

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