Perinatal outcomes of singleton siblings: the effects of changing maternal fertility status

Luke, Barbara; Gopal, Daksha; Cabral, Howard; Diop, Hafsatou; Stern, Judy E.

doi:10.1007/s10815-016-0757-6

Cited by 28 publications

(23 citation statements)

References 57 publications

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“…Repeated pregnancies themselves may be a contributing factor to the adverse outcomes observed in the commissioned births, although the evidence have been controversial (38,39). One study showed that in a sibling pair, the IVF/ICSI infant born after a previous spontaneous conception was more likely to have low birth weight and preterm birth (40).…”

Section: Discussionmentioning

confidence: 99%

Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: a model to evaluate IVF treatment versus maternal effects

Woo

Hindoyan

Landay

et al. 2017

Fertility and Sterility

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Neonates born from commissioned embryos and carried by gestational surrogates have increased adverse perinatal outcomes, including preterm birth, low birth weight, hypertension, maternal gestational diabetes, and placenta previa, compared with singletons conceived spontaneously and carried by the same woman. Our data suggest that assisted reproductive procedures may potentially affect embryo quality and that its negative impact can not be overcome even with a proven healthy uterine environment.

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Section: Discussionmentioning

confidence: 99%

Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: a model to evaluate IVF treatment versus maternal effects

Woo

Hindoyan

Landay

et al. 2017

Fertility and Sterility

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“…A meta-analysis of PTB in ART versus SC siblings including two Nordic studies showed an increased risk for PTB in the ART sibling (AOR 1.27, 95% CI 1.08 to 1.49), indicating a risk attributable to the ART treatment per se (Pinborg et al 2013). A sibship study from the USA also showed that subfertile women, with or without ART, were at increased risk for adverse perinatal outcomes when compared with fertile women (Luke et al 2016). Women whose fertility status declined from their first to their second singleton pregnancy had increased risks for adverse outcomes, and the highest risks were observed in those women with the steepest decline in their fertility status (Luke et al 2016).…”

Section: Sibling Studiesmentioning

confidence: 99%

“…A sibship study from the USA also showed that subfertile women, with or without ART, were at increased risk for adverse perinatal outcomes when compared with fertile women (Luke et al 2016). Women whose fertility status declined from their first to their second singleton pregnancy had increased risks for adverse outcomes, and the highest risks were observed in those women with the steepest decline in their fertility status (Luke et al 2016). Thus, subfertility plays a significant role in the adverse outcome in ART although it is not the only contributor.…”

Section: Sibling Studiesmentioning

confidence: 99%

The health of children conceived by ART: ‘the chicken or the egg?’

Berntsen

Söderström‐Anttila

Wennerholm

et al. 2019

Human Reproduction Update

308

226

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Long-term health Neurodevelopmental health Cardiovascular function and metabolism Growth Respiratory and allergic disorders Malignancies Reproductive health Controlled ovarian stimulation Laboratory factors Culture media Culture time Number of embryos transferred Oocyte donation and gestational surrogacy Oocyte vitrification Epigenetics Imprinting disorders The chicken or the egg? Subfertility and sibling studies Future research Conclusion The conclusion we can reach from the well designed studies aimed at disentangling the influence on child health of parental and ART factors is that both the chicken and the egg matter.

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“…This positive trend is due to more appropriate embryo transfer strategies, milder ovarian stimulation, laboratory technological advances, and improved culture media [5]. However, even in singleton pregnancy, after adjustment for maternal confounding factors, the risk of multiple adverse outcomes during the perinatal period, including miscarriage, preterm birth, small for gestational age, low birth weight and gestational hypertension, are higher in IVF-ET pregnancies than in spontaneously conceived pregnancies [6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

The placental transcriptome of the first-trimester placenta is affected by in vitro fertilization and embryo transfer

Zhao¹,

Zheng²,

Liu³

et al. 2019

Reprod Biol Endocrinol

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Background: The placenta is a highly specialized temporary organ that is related to fetal development and pregnancy outcomes, and epidemiological data demonstrate an increased risk of placental abnormality after in vitro fertilization and embryo transfer (IVF-ET). Methods: This study examines alterations in the transcriptome profile of first-trimester placentas from IVF-ET pregnancies and analyzes the potential mechanisms that play a role in the adverse perinatal outcomes associated with IVF-ET procedures. Four human placental villi from first-trimester samples were obtained through fetal bud aspiration from patients subjected to IVF-ET due to oviductal factors. An additional four control human placental villi were derived from a group of subjects who spontaneously conceived a twin pregnancy. We analyzed their transcriptomes by microarray. Then, RT-qPCR and immunohistochemistry were utilized to analyze several dysregulated genes to validate the microarray results. Biological functions and pathways were analyzed with bioinformatics tools. Results: A total of 3405 differentially regulated genes were identified as significantly dysregulated (> 2-fold change; P < 0.05) in the IVF-ET placenta in the first trimester: 1910 upregulated and 1495 downregulated genes. Functional enrichment analysis of the differentially regulated genes demonstrated that the genes were involved in more than 50 biological processes and pathways that have been shown to play important roles in the first trimester in vivo. These pathways can be clustered into coagulation cascades, immune response, transmembrane signaling, metabolism, cell cycle, stress control, invasion and vascularization. Nearly the same number of up-and downregulated genes participate in the same biological processes related to placental development and maintenance. Procedures utilized in IVF-ET altered the expression of first-trimester placental genes that are critical to these biological processes and triggered a compensatory mechanism during early implantation in vivo. Conclusion: These data provide a potential basis for further analysis of the higher frequency of adverse perinatal outcomes following IVF-ET, with the ultimate goal of developing safer IVF-ET protocols.

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Perinatal outcomes of singleton siblings: the effects of changing maternal fertility status

Abstract: Declining fertility status, with and without assisted reproductive technology treatment, is associated with increasing risks for adverse outcomes, greatest for women whose fertility status declined the most.

Cited by 28 publications

References 57 publications

Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: a model to evaluate IVF treatment versus maternal effects

Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: a model to evaluate IVF treatment versus maternal effects

The health of children conceived by ART: ‘the chicken or the egg?’

The placental transcriptome of the first-trimester placenta is affected by in vitro fertilization and embryo transfer

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