Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: a model to evaluate IVF treatment versus maternal effects

Woo, Irene; Hindoyan, Rita; Landay, Melanie; Ho, Jocelyn; Ingles, Sue A.; McGinnis, Lynda K.; Paulson, Richard J.; Chung, Karine

doi:10.1016/j.fertnstert.2017.09.014

Cited by 78 publications

(60 citation statements)

References 45 publications

(33 reference statements)

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“…The reasons for disapproval were similar to those for gamete donation. Gestational surrogacy has been reported to increase adverse perinatal outcomes, including preterm birth, low birth weight, hypertension, gestational diabetes, and placenta previa, compared with spontaneous pregnancy by the same women [ 12 ]. These were not mentioned, however, as reasons for disapproval in this study.…”

Section: Discussionmentioning

confidence: 99%

A survey of public attitudes towards third-party reproduction in Japan in 2014

et al. 2018

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ObjectiveThe objective of this study was to examine public attitudes towards third-party reproduction and the disclosure of conception through third-party reproduction.MethodsWe conducted the web-based survey for the public attitude towards third-party reproduction in February 2014. Twenty-five hundred people were recruited with equal segregation of age (20s, 30s, 40s, and 50s) and gender. We analyzed the association between gender, age, infertility, and ethical view using a questionnaire regarding donor sperm, donor oocyte, donor embryo, gestational surrogacy, and disclosure to offspring.ResultsOf the respondents, 36.2% approved and 26.6% disapproved of gamete or embryo donation. The frequency of those who approved was lowest in females in the 50–59 year age group, and was significantly higher in males or females with infertility. Secondly, 40.9% approved and 21.8% disapproved of gestational surrogacy. The frequency of those who approved gestational surrogacy was higher in males or females with infertility. Thirdly, 46.3% of respondents agreed and 20.4% disagreed with “offspring have the right to know their origin”. Those who disagreed were primarily in the 50–59 year age group of both genders, and disagreement was significantly higher in the infertility group compared with non-infertility group.ConclusionIn this study, public attitudes were affected by gender, age, and experience of infertility. These study findings are important in understanding the attitude towards third-party reproduction and disclosure to the offspring. Respondents having indecisive attitudes were >30%, which might indicate an increased requirement for information and education to enhance the discussion on the ethical consensus on third-party reproduction in Japan.

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Section: Discussionmentioning

confidence: 99%

A survey of public attitudes towards third-party reproduction in Japan in 2014

et al. 2018

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“…In a recent study pregnancy complications and perinatal outcomes were compared in live born singletons conceived with the use of embryos from intended parents (n =103) versus SC (n = 249) carried in the same woman (Woo et al 2017). Children born after GS had a lower mean gestational duration, higher rates of PTB (10.7% versus 3.1%, respectively), and higher rates of LBW (7.8% versus 2.4%, respectively).…”

Section: Gestational Surrogacymentioning

confidence: 99%

“…Children born after GS had a lower mean gestational duration, higher rates of PTB (10.7% versus 3.1%, respectively), and higher rates of LBW (7.8% versus 2.4%, respectively). The authors concluded that the results showed that ART may potentially affect embryo quality and that even a proven healthy uterine environment cannot compensate for this negative impact (Woo et al 2017). However, many factors might have affected the study outcome, for example an artificial replacement cycle versus natural cycle, number of embryos transferred, and the time interval between the SC and surrogate pregnancies (Spandorfer 2017).…”

Section: Gestational Surrogacymentioning

confidence: 99%

The health of children conceived by ART: ‘the chicken or the egg?’

Berntsen

Söderström‐Anttila

Wennerholm

et al. 2019

Human Reproduction Update

308

226

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Long-term health Neurodevelopmental health Cardiovascular function and metabolism Growth Respiratory and allergic disorders Malignancies Reproductive health Controlled ovarian stimulation Laboratory factors Culture media Culture time Number of embryos transferred Oocyte donation and gestational surrogacy Oocyte vitrification Epigenetics Imprinting disorders The chicken or the egg? Subfertility and sibling studies Future research Conclusion The conclusion we can reach from the well designed studies aimed at disentangling the influence on child health of parental and ART factors is that both the chicken and the egg matter.

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“…On the other hand, the top reasons for not approving were that familial relations are unnatural and that pregnancy should be natural. Gestational surrogacy has been reported to increase adverse perinatal outcomes, including preterm birth, low birth weight, hypertension, gestational diabetes, and placenta previa, compared with spontaneous pregnancy by the same women [12]. Although this fact can be a reason for not approving of gestational surrogacy, it was not main reason for disapproval in this study.…”

Section: Discussionmentioning

confidence: 53%

A survey of public attitudes towards third-party reproduction in Japan in 2014

Yamamoto

Hirata

Izumi

et al. 2018

Preprint

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20Objective: The objective of this study was to examine public attitudes towards third-party 21 reproduction and the disclosure of conception through third-party reproduction. 22Methods: We conducted the web-based survey for the public attitude towards third-party 23 reproduction in February 2014. Twenty-five hundred people were recruited with equal 24 segregation of age (20s, 30s, 40s, and 50s) and gender. We analyzed the association 25 between gender, age, infertility, and ethical view using a questionnaire regarding donor 26 sperm, donor oocyte, donor embryo, gestational surrogacy, and disclosure to offspring. 27Results: Of the respondents, 36.2% approved and 26.6% disapproved with gamete or 28 embryo donation. The frequency of those who approved was the lowest in females in the 29 50-59 years age group, and was significantly higher in males or females with infertility. 30Secondly, 40.9% approved and 21.8% disapproved with gestational surrogacy. The 31 frequency of those who approved gestational surrogacy was higher in males or females 32 with infertility. Thirdly, 46.3% of respondents agreed and 20.4% disagreed with 33 "offspring have the right to know their origin". Those who disagreed were primarily in 34 the 50-59 age group of both genders, and disagreement was significantly higher in the 35 infertility group compared with non-infertility group. 36Conclusion: In this study, public attitudes were affected by gender, age, and experience 3 37 of infertility. These study findings are important in understanding the attitude towards 38 third-party reproduction and disclosure to the offspring. Respondents having indecisive 39 attitudes were >30%, which might indicate an increased requirement for information and 40 education to enhance the discussion on the ethical consensus on third-party reproduction 41 in Japan. 42 43 44 45 46 47 48 49 50 51 52 53 54 4 55 Introduction 56 The treatment cycle of assisted reproductive technology (ART) has dramatically 57 increased; more than 1 million babies were born by ART between 2008 and 2010 [1]. In 58 Japan, 424151 treatment cycles were carried out in 2015, and 51001 neonates (1 in 19.7 59 neonates born in Japan) were born [2]. Although ART is now widely accepted as 60 clinically effective for treatment of many forms of subfertility, some people cannot 61 conceive due to poor reproductive function, for example, uterine infertility and poor 62 ovarian function. For those patients, ART using third party sperm, oocytes, or uterus is 63 an option, known as third-party reproduction. 64It is not technically difficult to perform third-party reproduction. Indeed, in the United 65States, there has been many cases of third-party reproduction, accounting for 16% of the 66 total ART [3]. However, ethical concerns have been raised about these fertility treatments. 67The attitudes toward third-party reproduction are different in each country, which also 68 depends on a country's law on whether oocyte donation is legal or not. For example, in 69 the EU, oocyte donation is permitted under c...

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Perinatal outcomes after natural conception versus in vitro fertilization (IVF) in gestational surrogates: a model to evaluate IVF treatment versus maternal effects

Cited by 78 publications

References 45 publications

A survey of public attitudes towards third-party reproduction in Japan in 2014

A survey of public attitudes towards third-party reproduction in Japan in 2014

The health of children conceived by ART: ‘the chicken or the egg?’

A survey of public attitudes towards third-party reproduction in Japan in 2014

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