Periferik Sinir Rejenerasyonu ve Kök Hücre Tedavileri

Abstract

In this review, authors aimed to give information about the recent development about the use of stem cell transplantation in damaged nerve repair and highlight the key scientifi c studies. Although peripheral nerves show the potential of regenerating the axon and reinnerveting their target tissues, the recovery after intense nerve injury remains relatively poor. Schwann cells play important role in the regeneration success of peripheral nerves. Given that Schwann cells of the denervated peripheral nerve appear to become incapable in regeneration, it has been considered a reasonable approach to support the distal denervated nerve environment with exogenously derived host cells. The effects of various stem cells on peripheral nerve regeneration have been investigated. Skin, bone marrow and adipose derived stem cells were indicated as the most promising candidates with their potentials of converting into Schwann cells. Beside the application of pluripotent induced stem cell trials; recent studies have demonstrated that induced expression of growth factors in stem cells has more potential in regeneration. Although the stem cells were considered as effi cient resources and promising agents in nerve regeneration there is no optimization of these therapies yet for their potential to be realized in a clinical setting.