Allantoin, a purine metabolite, enhances peripheral nerve regeneration following sciatic nerve injury in rats: A stereological and immunohistochemical study

Pigment epithelium‐derived factor enhances peripheral nerve regeneration through modulating oxidative stress and stem cells

“…T A B L E 1 Scoring of the expression of anti-S100 and anti-Ki-67 belonging to the groups in Schwann cells and areas of epineurium, perineurium, and endoneurium. The study of nerve repair and regeneration has a long history and is undoubtedly the most addressed problem in the study of the peripheral nervous system (Delibas et al, 2021;Herrera-Rincon et al, 2022;Sagir et al, 2020). Experimental research on mechanical nerve compression has been conducted to examine the changes in the proximal and distal anatomical structures of the lesion in the sciatic nerve (Challa, 2015).…”

“…Grounding was used to prevent the uncontrolled movement of the stimulating electrode. The surface of the electrodes in the device (Powerlab 4SP, AD Instruments, Sydney, Australia) was covered, and only the excitatory ends were in contact with the nerve (Delibas et al, 2021; Onger et al, 2017a).…”

“…The stained sections were evaluated semi-quantitatively. In immunolabeling grading, areas with no or minimal staining are with "+/À"; areas with less than 25% staining are marked with "+"; areas with 25-50% staining with "+ +"; areas with 50-75% staining with "+++"; the areas with >75% staining were evaluated with "++++" (Delibas et al, 2021). The evaluation was performed on different parts of the five different sections for each group.…”

Neuropathologic damage induced by radiofrequency ablation at different temperatures – An Experimental Study

“…The pathological manifestations in peripheral nerve after electric burn are characterized by cell disintegration, axonal degeneration, nerve fiber swelling, and demyelination. 10 The changes in cell structure and function after RFA have been widely observed, but the changes of macromolecular functional proteins and their effects on cell function have not been studied. There are different kinds of neural ion channels including SCN9A a large molecular protein that undergoes thermal damage both structurally and functionally.…”

Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds

“…It is widely used for tissue regeneration and wound healing [ 38 , 39 ] due to its biocompatibility [ 34 , 36 ], anti-inflammatory and anti-nociceptive effects [ 40 , 41 , 42 ], and anti-secretory and gastroprotective activity [ 42 ]. Further, recently, in vitro and in vivo assays with allantoin alone or in combination with other natural extracts confirm its potential in nerve regeneration [ 43 , 44 ], antibacterial activity [ 38 ], and anti-fungal effects against multidrug-resistant yeasts [ 45 ].…”