Periconianone A, a New 6/6/6 Carbocyclic Sesquiterpenoid from Endophytic Fungus Periconia sp. with Neural Anti-inflammatory Activity

Abstract

Periconianone A (1), a polyoxygenated sesquiterpenoid with a new 6/6/6 tricarbocyclic skeleton, and periconianone B (2) were isolated from the endophytic fungus Periconia sp. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction (Cu Kα). The biosynthesis of the unusual six-membered carbonic ring of 1 was postulated to be formed through intramolecular aldol condensation. Compounds 1 and 2 showed significant neural anti-inflammatory activity.

Plant Bioactive Metabolites and Drugs Produced by Endophytic Fungi of Spermatophyta

“…not specified [88] Periconianone B Periconia sp. Annona muricata [89] Pestalotiopsin A-B P. photiniae P. macrophyllus [90] Phomadecalins Microdiplodia sp. Pinus sp.…”

New Duclauxamide from Penicillium manginii YIM PH30375 and Structure Revision of the Duclauxin Family

“…This deficiency, combined with the strong track record of TCM use in China, suggests that endophytes, particularly those associated with TCM plants, are likely to yield new natural products. 4 The stem of Panax notoginseng (Burk.) F.H.…”

New 2-arylbenzofuran metabolite from cell cultures ofMorus alba

“…Compounds 1 -8 were biologically assayed for neural anti-inflammatory activity using lipopolysaccharide (LPS)-induced NO production in mouse microglia BV2 cells [21]. Among these compounds, 2 and 8 exhibited significant inhibitory activity toward LPS-induced NO production with the values of 76.4% and 98.7% at 10 25 M, respectively.…”