New 2-arylbenzofuran metabolite from cell cultures ofMorus alba

Abstract

A new 2-arylbenzofuran compound, 5-dehydroxy-moracin U (1), along with 10 known compounds (2-11), were isolated from cell cultures of Morus alba. Their structures were elucidated on the basis of extensive spectroscopic analyses. The anti-inflammatory activity assay of 1-8 showed that 2 and 8 exhibited significant inhibitory effect on LPS-induced NO production with the values of 76.4% and 98.7% at 10(- 5) M, respectively.

Morusalones A–D, Diels–Alder Adducts with 6/7/6/6/6/6 Hexacyclic Ring Systems as Potential PTP1B Inhibitors from Cell Cultures of Morus alba

“…As part of our continuing search for structurally novel natural compounds from cell cultures of this plant species, , further detailed investigation led to the isolation of four new Diels–Alder adducts, morusalones A–D ( 1 – 4 , Figure ). Morusalones A and B are two pairs of novel Diels–Alder adduct enantiomers with unprecedented 6/7/6/6/6/6 hexacyclic ring cores and are the first examples of Diels–Alder adduct enantiomers from the genus Morus .…”