Performance of TMC-g-PEG-VAPG/miRNA-145 complexes in electrospun membranes for target-regulating vascular SMCs

Wen, Meiling; Zhou, Fang; Cui, Chong; Zhao, Yunhui; Yuan, Xiaoyan

doi:10.1016/j.colsurfb.2019.110369

Cited by 23 publications

(20 citation statements)

References 46 publications

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“…Similarly, miR-145-loaded trimethyl chitosan-g-poly(ethylene glycol) (TMC-g-PEG-VAPG) was constructed by Yuan et al to inhibit VSMCs. 66 3.2.3. MiR-21 antagonist.…”

Section: Therapeutic Agents For Inhibiting the Hyperproliferation Of ...mentioning

confidence: 99%

“…Val-Ala-Pro-Gly (VAPG) is well known as a VSMC targeting peptide that can improve the adhesion of VSMCs via targeting recognition of b3 receptor on the plasma membrane of VSMCs. Yuan's group developed miRNA-145 gene complexes based on dextran-g-poly(L-lysine)-VAPG 65 and TMC-g-PEG-VAPG 66 as gene carriers to functionalize electrospun PLGA membranes for enhanced targeting ability to VSMCs. However, VAPG peptide cannot mediate the targeting of atherosclerotic lesions in the body.…”

Section: Ligand-receptor Systems To Enhance the On-target Effectmentioning

confidence: 99%

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Recent advances in inhibiting atherosclerosis and restenosis: from pathogenic factors, therapeutic molecules to nano-delivery strategies

2022

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“…Similarly, miR-145-loaded trimethyl chitosan-g-poly(ethylene glycol) (TMC-g-PEG-VAPG) was constructed by Yuan et al to inhibit VSMCs. 66 3.2.3. MiR-21 antagonist.…”

Section: Therapeutic Agents For Inhibiting the Hyperproliferation Of ...mentioning

confidence: 99%

Section: Ligand-receptor Systems To Enhance the On-target Effectmentioning

confidence: 99%

Recent advances in inhibiting atherosclerosis and restenosis: from pathogenic factors, therapeutic molecules to nano-delivery strategies

2022

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show abstract

“…Other peptides have been developed to deliver microRNAs (miRNAs) to VSMCs. Wen et al [171] developed a Val-Ala-Pro-Gly (VAPG) peptide-modified trimethyl chitosan-g-PEG (TPV) for the targeted delivery of miRNA-145 and incorporated it into electrospun PLCL. miRNA-145 can regulate contractile VSMCs and avoid excessive proliferation and intimal hyperplasia.…”

Section: Modulation Of the Vsmc Layer Formation On Tevg By Vsmc Regulating Compoundsmentioning

confidence: 99%

Electrospun nanofiber scaffold for vascular tissue engineering

Rickel

Deng

Engebretson

et al. 2021

Materials Science and Engineering: C

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Due to the prevalence of cardiovascular diseases, there is a large need for small diameter vascular grafts that cannot be fulfilled using autologous vessels. Although medium to large diameter synthetic vessels are in use, no suitable small diameter vascular graft has been developed due to the unique dynamic environment that exists in small vessels. To achieve long term patency, a successful tissue engineered vascular graft would need to closely match the mechanical properties of native tissue, be non-thrombotic and non-immunogenic, and elicit the proper healing response and undergo remodeling to incorporate into the native vasculature. Electrospinning presents a promising approach to the development of a suitable tissue engineered vascular graft. This review provides a comprehensive overview of the different polymers, techniques, and functionalization approaches that have been used to develop an electrospun tissue engineered vascular graft.

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“…In this regard, Yuan et al conjugated a short peptide (VAPG) through its disulfide linkage to quaternized TMC (26, Figure 8); electrospun nanofiber loaded peptide-miRNA 145 complex successfully delivered miRNA-145 to vascular smooth muscle cells (SMCs). 139 The same group also delivered miRNA-126 to vascular endothelial cells through conjugation of another short peptide Arg-Glu-Asp-Val (REDV) linked to TMC via a bifunctional poly(ethylene glycol) (PEG) linker (27, Figure 8). 140 Polyethylenimine (PEI) are considered as another effective gene delivery agent which forms a charged complex with the gene due to the presence of cationic charges.…”

Section: Peptide−chitosan Conjugatesmentioning

confidence: 99%

Peptide-Chitosan Engineered Scaffolds for Biomedical Applications

et al. 2021

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Peptides are signaling epitopes that control many vital biological events. Increased specificity, synthetic feasibility with concomitant lack of toxicity, and immunogenicity make this emerging class of biomolecules suitable for different applications including therapeutics, diagnostics, and biomedical engineering. Further, chitosan, a naturally occurring linear polymer composed of D-glucosamine and N-acetyl-D-glucosamine units, possesses anti-microbial, muco-adhesive, and hemostatic properties along with excellent biocompatibility. As a result, chitosan finds application in drug/gene delivery, tissue engineering, and bioimaging. Despite these applications, chitosan demonstrates limited cell adhesion and lacks biosignaling. Therefore, peptide−chitosan hybrids have emerged as a new class of biomaterial with improved biosignaling properties and cell adhesion properties. As a result, recent studies encompass increased application of peptide−chitosan hybrids as composites or conjugates in drug delivery, cell therapy, and tissue engineering and as anti-microbial material. This review discusses the recent investigations involving chitosan−peptide materials and uncovers various aspects of these interesting hybrid materials for biomedical applications.

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Performance of TMC-g-PEG-VAPG/miRNA-145 complexes in electrospun membranes for target-regulating vascular SMCs

Cited by 23 publications

References 46 publications

Recent advances in inhibiting atherosclerosis and restenosis: from pathogenic factors, therapeutic molecules to nano-delivery strategies

Recent advances in inhibiting atherosclerosis and restenosis: from pathogenic factors, therapeutic molecules to nano-delivery strategies

Electrospun nanofiber scaffold for vascular tissue engineering

Peptide-Chitosan Engineered Scaffolds for Biomedical Applications

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