Peptide-Chitosan Engineered Scaffolds for Biomedical Applications

Kulkarni, Neeraj; Shinde, Suchita Dattatray; Jadhav, Govinda Shivaji; Adsare, Diksha Ramesh; Rao, K. Purushotham; Kachhia, Mihir; Maingle, Mohit; Patil, Shubham Prakash; Arya, Neha; Sahu, Bichismita

doi:10.1021/acs.bioconjchem.1c00014

Cited by 24 publications

(18 citation statements)

References 177 publications

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“…Chitosan-polymer materials display amphiphilic behavior that dispenses in organic solvents and could be utilized in multiple medical applications like engineering tissues and bone reconstruction [111]. Peptide chitosan hybrids have biosignaling properties and cell adhesion properties that could be utilized for drug delivery, cell therapy, and engineering tissues.…”

Section: Role In Biomedical Applicationmentioning

confidence: 99%

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Retracted: Advances in chitosan biopolymer composite materials: from bioengineering, wastewater treatment to agricultural applications

Chadha

Bhardwaj

Selvaraj

et al. 2022

Mater. Res. Express

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Chitosan has become the most known and second abundantly available recyclable, non-hazardous and eco-friendly biopolymer after cellulose with several advantageous biomedical, agriculture, and wastewater treatment applications. As nanotechnology has progressed, researchers have begun incorporating chitosan-based carbon compounds into various compounds, elements, and carbonaceous materials to increase their efficiency and biocompatibility. Chitosan carbon compounds have also been used directly in many applications due to their inherent chelating and antibacterial features and the presence of customizable functional groups. In this review, synthesis technologies and microstructure of chitosan composites and its carbon materials in biomedical, agriculture, and wastewater treatment concerning the administration of abiotic stress within plants, water accessibility for crops, scheming food bear pathogens, photothermal cancer rehabilitation, and heavy water pollutants absorption and removal methods are widely deliberated upon, with a relevant discussion of the techniques that can be used to put these into action. Chitosan is also utilized in miscellaneous applications, including the food sector and cosmetics. Overall, chitosan-based carbon compounds promise to extend agricultural practices while also addressing health concerns in an environmentally friendly manner.

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Section: Role In Biomedical Applicationmentioning

confidence: 99%

“…It preserves the purity of the finished matrix as no catalyst or initiators are added to the solid-state reactive blend. These polymeric materials find multiple applications in the biomedical field [111].…”

Section: Role In Biomedical Applicationmentioning

confidence: 99%

Retracted: Advances in chitosan biopolymer composite materials: from bioengineering, wastewater treatment to agricultural applications

Chadha

Bhardwaj

Selvaraj

et al. 2022

Mater. Res. Express

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“…Plant derived proteins and polysaccharides have proved to be more sustainable and less expensive than their animal counterpart, overcoming some issues in extraction and source recovery 37 . However, stable and water-resistant scaffolds can be obtained only after crosslinking or blending steps 38 – 40 .…”

Section: Introductionmentioning

confidence: 99%

Advanced mycelium materials as potential self-growing biomedical scaffolds

Antinori

Contardi

Suarato

et al. 2021

Sci Rep

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Mycelia, the vegetative part of fungi, are emerging as the avant-garde generation of natural, sustainable, and biodegradable materials for a wide range of applications. They are constituted of a self-growing and interconnected fibrous network of elongated cells, and their chemical and physical properties can be adjusted depending on the conditions of growth and the substrate they are fed upon. So far, only extracts and derivatives from mycelia have been evaluated and tested for biomedical applications. In this study, the entire fibrous structures of mycelia of the edible fungi Pleurotus ostreatus and Ganoderma lucidum are presented as self-growing bio-composites that mimic the extracellular matrix of human body tissues, ideal as tissue engineering bio-scaffolds. To this purpose, the two mycelial strains are inactivated by autoclaving after growth, and their morphology, cell wall chemical composition, and hydrodynamical and mechanical features are studied. Finally, their biocompatibility and direct interaction with primary human dermal fibroblasts are investigated. The findings demonstrate the potentiality of mycelia as all-natural and low-cost bio-scaffolds, alternative to the tissue engineering systems currently in place.

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“…Natural polymers such as chitosan polysaccharides, composed of β-(1 4)-linked D-glucosamine and N -acetyl-D-glucosamine units, have been used extensively as a nanocarrier for oral peptide delivery [ 28 ]. Chitosan-based NPs exhibited excellent biocompatibility and gastrointestinal (GI) absorption and have been used to deliver anticancer agents [ 29 , 30 ]. With respect to therapeutic peptide delivery, Kanwar et al demonstrated that lactoferrin polypeptide-loaded chitosan NPs can effectively activate apoptotic pathways in colon cancer and cancer stem cells [ 31 ].…”

Section: Peptide Modifications For Enhanced Delivery and Stabilitymentioning

confidence: 99%

Novel Peptide Therapeutic Approaches for Cancer Treatment

Haratipour

Lingeman

et al. 2021

Cells

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Peptides are increasingly being developed for use as therapeutics to treat many ailments, including cancer. Therapeutic peptides have the advantages of target specificity and low toxicity. The anticancer effects of a peptide can be the direct result of the peptide binding its intended target, or the peptide may be conjugated to a chemotherapy drug or radionuclide and used to target the agent to cancer cells. Peptides can be targeted to proteins on the cell surface, where the peptide–protein interaction can initiate internalization of the complex, or the peptide can be designed to directly cross the cell membrane. Peptides can induce cell death by numerous mechanisms including membrane disruption and subsequent necrosis, apoptosis, tumor angiogenesis inhibition, immune regulation, disruption of cell signaling pathways, cell cycle regulation, DNA repair pathways, or cell death pathways. Although using peptides as therapeutics has many advantages, peptides have the disadvantage of being easily degraded by proteases once administered and, depending on the mode of administration, often have difficulty being adsorbed into the blood stream. In this review, we discuss strategies recently developed to overcome these obstacles of peptide delivery and bioavailability. In addition, we present many examples of peptides developed to fight cancer.

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Peptide-Chitosan Engineered Scaffolds for Biomedical Applications

Cited by 24 publications

References 177 publications

Retracted: Advances in chitosan biopolymer composite materials: from bioengineering, wastewater treatment to agricultural applications

Retracted: Advances in chitosan biopolymer composite materials: from bioengineering, wastewater treatment to agricultural applications

Advanced mycelium materials as potential self-growing biomedical scaffolds

Novel Peptide Therapeutic Approaches for Cancer Treatment

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