Performance improvement of cephalosporin C fermentation by Acremonium chrysogenum with DO-Stat based strategy of co-feeding soybean oil and glucose

Luo, Hongzhen; Zhang, Jingshu; Gao, Yuan; Zhao, Yanli; Han, Lei; He, Zhenni; Shi, Zhongping

doi:10.1016/j.procbio.2013.09.021

Cited by 6 publications

(8 citation statements)

References 24 publications

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“…Feeding soybean oil and glucose at a ratio of 1 : 0·7 improved the fermentation performance (Luo et al . ), and Adinarayana et al . () obtained maximum yield by using 1 wt% starch and 1 wt% yeast extract as the additives (Adinarayana et al .…”

Section: Introductionmentioning

confidence: 86%

“…As for other studies on cephalosporin C (CPC), Luo et al . () studied the CPC fermentation process by using Acremonium chrysogenum . Feeding soybean oil and glucose at a ratio of 1 : 0·7 improved the fermentation performance (Luo et al .…”

Section: Introductionmentioning

confidence: 99%

“…As for other studies on cephalosporin C (CPC), Luo et al (2013) studied the CPC fermentation process by using Acremonium chrysogenum. Feeding soybean oil and glucose at a ratio of 1 : 0Á7 improved the fermentation performance (Luo et al 2013), and Adinarayana et al (2003) obtained maximum yield by using 1 wt% starch and 1 wt% yeast extract as the additives (Adinarayana et al 2003). Shin et al (2011) and Cruz et al (2001) reported increased CPC yield through fed batch culture (Cruz et al 2001;Shin et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Utilization of algal sugars and glycerol for enhanced cephalosporin C production by Acremonium chrysogenum M35

Lee

Yoo

Yang

et al. 2016

Lett Appl Microbiol

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Microalgae are the biomass containing various components, such as carbohydrates, lipids, and amino acids. In this study, carbon sources contained in microalgae were obtained by acid extraction, and cephalosporin C (CPC), a β-lactam antibiotic intermediate, was produced by using Acremonium chrysogenum M35. In addition, the increase of CPC production was not distinct for A. chrysogenum M35 with algal sugars as the only carbon source; therefore, glycerol was added, increasing the CPC production. Thus, cheap residues such as algal sugars form microalgal and glycerol form biodiesel process could be used as the alternative sources for the production of various products.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Utilization of algal sugars and glycerol for enhanced cephalosporin C production by Acremonium chrysogenum M35

Lee

Yoo

Yang

et al. 2016

Lett Appl Microbiol

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“…6.0) embedded in the industrial computer. This automatic feeding strategy was successfully applied in cephalosporin C production by another fungus (A. chrysogenum HC-3) in our previous study [12].…”

Section: Substrate Feeding Strategiesmentioning

confidence: 99%

Efficient and Cost-Reduced Glucoamylase Fed-Batch Production with Alternative Carbon Sources

Luo¹,

Liu²,

He³

et al. 2015

Journal of Microbiology and Biotechnology

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Glucoamylase is an important industrial enzyme. Glucoamylase production by industrial Aspergillus niger strain featured with two major problems: (i) empirical substrate feeding methods deteriorating the fermentation performance; and (ii) the high raw materials cost limiting the economics of the glucoamylase product with delegated specification. In this study, we first proposed a novel three-stage varied-rate substrate feeding strategy for efficient glucoamylase production in a 5 L bioreactor using the standard feeding medium, by comparing the changing patterns of the important physiological parameters such as DO, OUR, RQ, etc., when using different substrate feeding strategies. With this strategy, the glucoamylase activity and productivity reached higher levels of 11,000 U/ml and 84.6 U/ml/h, respectively. The performance enhancement in this case was beneficial from the following results: DO and OUR could be controlled at the higher levels (30%, 43.83 mmol/l/h), while RQ was maintained at a stable/lower level of 0.60 simultaneously throughout the fed-batch phase. Based on this three-stage varied-rate substrate feeding strategy, we further evaluated the economics of using alternative carbon sources, attempting to reduce the raw materials cost. The results revealed that cornstarch hydrolysate could be considered as the best carbon source to replace the standard and expensive feeding medium. In this case, the production cost of the glucoamylase with delegated specification (5,000 U/ml) could be saved by more than 61% while the product quality be ensured simultaneously. The proposed strategy showed application potential in improving the economics of industrial glucoamylase production.

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“…Previous studies have shown that pH plays a central role in the microbial growth and metabolite accumulation [26][27][28][29]. In general, the effects of pH on the cell growth and product accumulation vary with microorganisms, medium composition, and operating conditions [30,31]. To our knowledge, there have been few reports about the effects of pH on the production of MPA, biosynthesis of their precursor, and feeding strategy in batch fermentation in the stirred tank bioreactors.…”

Section: Introductionmentioning

confidence: 99%

A combined feeding strategy for enhancing mycophenolic acid production by fed-batch fermentation in Penicillium brevicompactum

Dong

Wang

et al. 2015

Process Biochemistry

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Performance improvement of cephalosporin C fermentation by Acremonium chrysogenum with DO-Stat based strategy of co-feeding soybean oil and glucose

Cited by 6 publications

References 24 publications

Utilization of algal sugars and glycerol for enhanced cephalosporin C production by Acremonium chrysogenum M35

Utilization of algal sugars and glycerol for enhanced cephalosporin C production by Acremonium chrysogenum M35

Efficient and Cost-Reduced Glucoamylase Fed-Batch Production with Alternative Carbon Sources

A combined feeding strategy for enhancing mycophenolic acid production by fed-batch fermentation in Penicillium brevicompactum

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