Utilization of algal sugars and glycerol for enhanced cephalosporin C production by Acremonium chrysogenum M35

Abstract

Microalgae are the biomass containing various components, such as carbohydrates, lipids, and amino acids. In this study, carbon sources contained in microalgae were obtained by acid extraction, and cephalosporin C (CPC), a β-lactam antibiotic intermediate, was produced by using Acremonium chrysogenum M35. In addition, the increase of CPC production was not distinct for A. chrysogenum M35 with algal sugars as the only carbon source; therefore, glycerol was added, increasing the CPC production. Thus, cheap residues such as algal sugars form microalgal and glycerol form biodiesel process could be used as the alternative sources for the production of various products.

Carbon catabolite regulation of secondary metabolite formation, an old but not well‐established regulatory system

“…Thus, the use of extracts from the algae Chlorella pyranoidosa , which contains carbohydrates, proteins and lipids, is a good example. The culture medium with algae extracts and supplemented with 6% glycerol increased antibiotic production (Lee et al ., 2017 ).…”