Performance characteristics of a Labetalol‐H plus‐tetraphenylborate selective electrode

Voulgaropoulos, Anastasios; Sofoniou, Michalis; Kazakou, Eleni

doi:10.1002/elan.1140050524

Cited by 8 publications

(5 citation statements)

References 17 publications

(8 reference statements)

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“…The developed electrode and the electrode described in the literature [13] are characterised by many di®erent parameters. In the¯rst case the calibration curve slope is 0.061 V/decade and it is higher than the Nerstian slope.…”

Section: Discussionmentioning

confidence: 99%

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Analytical applications of electrode sensitive to labetalol in pharmaceuticals

et al. 2003

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The analytical properties of an ion-selective electrode sensitive to labetalol with a liquid membrane, based on ion-pair complexes with sodium tetraphenylborate (TPBNa + ) are described. The studied electrode can be used for the determination of labetalol hydrochloride as a protonated form of labetalol in pharmaceuticals. The calibration curve, e.g. EMF=f(pC LabHC l ) is linear in the range from 10 ¡5 to 10 ¡2 mol L ¡1 with a correlation coe¯cient of 0.9992 and slope of 61.13 mV/decade, which is close to the Nernstian slope. The detection limit of the examined electrode is 7.20£10 ¡6 mol L ¡1 . The in®uence of pH of the tested solutions on the formulation of the electrode is not as considerable since the electrode works correctly in the pH range 3.0-8.0. The main attributes of the developed electrode are: stability, good reproducibility of EMF and short response time, close to 30 seconds depending on labetalol concentration in the solution. The electrode shows good selectivity for many inorganic ions. The selectivity for drug cations is weaker due to the structural similarity of the interfering cations to labetalol. The results of labetalol determination using direct potentiometry in drugs such as Pressocard (Polpharma) and Trandate (GlaxoWellcome) were compatible with the quantity of labetalol declared by the manufacturer, and with parallel UV spectrophotometric and HPLC determinations.

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Section: Discussionmentioning

confidence: 99%

“…Labetalol has also been determined in plasma, urine and blood [10][11][12]. An ion-selective membrane electrode with a PVC matrix has been applied [13]. However, the majority of these methods are very elaborate and time consuming requiring expensive apparatus to apply them.…”

Section: Scheme 1 the Chemical Formula Of Labetalol Hydrochloride (Lamentioning

confidence: 99%

Analytical applications of electrode sensitive to labetalol in pharmaceuticals

et al. 2003

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“…1) is used in the treatment of hypertension, now clinically. 8,9 Among the cited electrochemical methods, they mainly discuss the voltammetric determination of LBT in pharmaceuticals and the spiked human urine at a bare carbon paste electrode 8 and the performance characteristics of labetalol-H on an ion selective membrane electrode. 1 Due to its clinical importance, many analytical techniques has been developed for its determination, including high performance liquid chromatography (HPLC), 2,3 liquid chromatography coupled with mass spectrometry 282 ZHANG, DUAN and GAO (LC-MS), 4 capillary electrophoresis (CE), 5,6 spectrophotometry 7 and electrochemical methods.…”

Section: Introductionmentioning

confidence: 99%

“…It is most commonly prescribed as a first line agent for the treatment of hypertensive disorders of pregnancy, including pre-eclampsia. 9 However, its electrochemical behaviors, electrochemical kinetics and electrochemical determination at an ionic liquid 1-benzyl-3-methylimidazole hexafluorophosphate ([BnMIM]PF 6 ) modified carbon paste electrode ([BnMIM]PF 6 /CPE) have not hitherto been reported. 8,9 Among the cited electrochemical methods, they mainly discuss the voltammetric determination of LBT in pharmaceuticals and the spiked human urine at a bare carbon paste electrode 8 and the performance characteristics of labetalol-H on an ion selective membrane electrode.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical behavior of labetalol at an ionic liquid modified carbon paste electrode and its electrochemical determination

Zhang¹,

Duan²,

Gao³

2013

JSCS

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Electrochemical behavior of labetalol (LBT) at carbon paste electrode (CPE) and an ionic liquid1-benzyl-3-methylimidazolehexafluorophosphate([BnMIM]PF6)modified carbon paste electrode([BnMIM]PF6/CPE)in Britton-Robinson buffer solution (pH 2.0) was investigated by cyclic voltammetry (CV) and square wave voltammetric (SWV). The experimental results showed that LBT at both the bare CPE and [BnMIM]PF6/CPEshowed an irreversible oxidation process, but at [BnMIM]PF6/CPE its oxidation peak current increased greatly and the oxidation peak potential shifted negatively. The electrode reaction process is a diffusion-controlled process involving one electron transferring accompanied by a participation of one proton at [BnMIM]PF6/CPE. At the same time, the electrochemical kinetic parameters were determined. Under the optimized electrochemical experimental conditions, the oxidation peak currents were proportional to LBT concentration in the range of 7.0 x 10-6-1.0 x 10-4 mol L-1 with the limit of detection(LOD, S/N=3) of 4.810 x 10-8 mol L-1and the limit of quantification(LOQ, S/N=10) of 1.60 x 10-7 mol L-1, respectively. The proposed method was successfully applied in the determination of LBT content in commercial tablet samples

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“…Several analytical methods have been developed to determine the concentrations of Labetalol in biological fluids and pharmaceutical preparations based on spectrophotometry [3][4][5][6][7][8] spectro-fluorometry 8,9 , potentiometry 10 , thinlayer chromatography (TLC) 11,12 , high performance liquid chromatography (HPLC) with UV 13 and electrochemical detection (ED) 14 , gas chromatography (GC) 15 and micellar liquid chromatography 16 . Although these methods have been successfully employed, they require long and tedious steps for the sample pretreatment.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2010

IJPSR

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A simple and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for estimation of Labetalol in human plasma, an adrenergic β-receptor blocking agent used in the treatment of hypertension, which exhibits both α-and β-adrenoreceptor blocking activity. The analyte and internal standard (Metoprolol) were extracted by liquid/liquid extraction with ethyl acetate. The chromatographic separation was performed on reverse phase Phenomenax Luna column (C18, 5µm, 100 x 4.6 mm) with a mobile phase of 2 mM ammonium formate (pH 5.0) / methanol (20:80 v/v), which was pumped at a flow rate of 0.5 mL / min with split ratio of 20:80. The protonated analyte was quantitated in positive ionization by multiple reactions monitoring with a mass spectrometer. The mass transitions m/z 329.01→161.95 and 267.99→115.86 were used to measure Labetalol and Metoprolol, respectively. The lower limit of quantitation was 3.1800 ng/mL with a relative standard deviation of less than 15%. Acceptable precision and accuracy were obtained for concentrations over the calibration curve ranges (3.1800 to 700.8760 ng/ml). Sample analysis time of 2.5 min for each sample made it possible to analyze a throughput of more than 400 human plasma samples per day.

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Performance characteristics of a Labetalol‐H plus‐tetraphenylborate selective electrode

Cited by 8 publications

References 17 publications

Analytical applications of electrode sensitive to labetalol in pharmaceuticals

Analytical applications of electrode sensitive to labetalol in pharmaceuticals

Electrochemical behavior of labetalol at an ionic liquid modified carbon paste electrode and its electrochemical determination

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