Electrochemical behavior of labetalol at an ionic liquid modified carbon paste electrode and its electrochemical determination

Abstract

Electrochemical behavior of labetalol (LBT) at carbon paste electrode (CPE) and an ionic liquid1-benzyl-3-methylimidazolehexafluorophosphate([BnMIM]PF6)modified carbon paste electrode([BnMIM]PF6/CPE)in Britton-Robinson buffer solution (pH 2.0) was investigated by cyclic voltammetry (CV) and square wave voltammetric (SWV). The experimental results showed that LBT at both the bare CPE and [BnMIM]PF6/CPEshowed an irreversible oxidation process, but at [BnMIM]PF6/CPE its oxidation peak current increased greatly and the oxidation peak potential shifted negatively. The electrode reaction process is a diffusion-controlled process involving one electron transferring accompanied by a participation of one proton at [BnMIM]PF6/CPE. At the same time, the electrochemical kinetic parameters were determined. Under the optimized electrochemical experimental conditions, the oxidation peak currents were proportional to LBT concentration in the range of 7.0 x 10-6-1.0 x 10-4 mol L-1 with the limit of detection(LOD, S/N=3) of 4.810 x 10-8 mol L-1and the limit of quantification(LOQ, S/N=10) of 1.60 x 10-7 mol L-1, respectively. The proposed method was successfully applied in the determination of LBT content in commercial tablet samples

Electrochemical determination of traces lead ions using a new nanocomposite of polypyrrole/carbon nanofibers

“…1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 indicating a poor electron transfer reaction of [Fe(CN)6] 3-/4at the bare CPE, while the increases respectively from 6 to 255 µF cm -2 . Indeed, the presence of the non-conductive paraffin oil at the electrode surface decrease the active surface area and then the electron transfer [47]. However, the electrical properties of CPE were improved after its modification by the functionalized CNFs, inducting their role to promote the electron transfer as reported previously using CNFs and other CNMs [11,12,46,48].…”

Electrochemical screening of selected β-blockers at a polarized liquid–liquid interface

“…Additionally, by analyzing positive and negative peak current values, we determined the diffusion coefficients for all investigated β-blockers, which provided insights into the diffusivity of analytes in both the aqueous and organic phases. The peak current values were plotted against the square root of the increasing scan rates (5,10,15,20,25,30, and 35 mV s −1 ) at a fixed concentration of the β-blocker. The rearranged Randles-Ševčík equation, is represented as:…”

“…The linear range was established from 0.1 to 10 µmol L −1 and the obtained LOD was equal to 0.46 µmol L −1 . 22 β-Blockers were studied using a variety of electrode types with techniques such as differential pulse voltammetry (DPV), 23,24 square wave voltammetry (SWV), 23,25 and cyclic voltammetry (CV). 23,25 This article reports on the electrochemical behavior of β-blockers at the electrified liquid-liquid interface (eLLI), also known as the interface between two immiscible electrolyte solutions (ITIES).…”

“…22 β-Blockers were studied using a variety of electrode types with techniques such as differential pulse voltammetry (DPV), 23,24 square wave voltammetry (SWV), 23,25 and cyclic voltammetry (CV). 23,25 This article reports on the electrochemical behavior of β-blockers at the electrified liquid-liquid interface (eLLI), also known as the interface between two immiscible electrolyte solutions (ITIES). ITIES-based systems have emerged as a new research area providing unique insights into the processes of the interfacial charge transfer mechanism.…”

“…The linear range was established from 0.1 to 10 μmol L −1 and the obtained LOD was equal to 0.46 μmol L −1 . 22 β-Blockers were studied using a variety of electrode types with techniques such as differential pulse voltammetry (DPV), 23,24 square wave voltammetry (SWV), 23,25 and cyclic voltammetry (CV). 23,25…”