“…The HEPA filter induces significant alterations in the gill and stomach tissue, with concentrations ranging from 50-60%. air reaching 99.97% of aerosols with a size of 0.3μm, which is the most penetrating particle size (MPPS) (Ku et al, 2023). The usage of HEPA filter in a room can also increase the effectiveness of air change per hour (ACH), and remove particles, reducing the risk of transmission in general wards with insufficient isolation rooms, as is the case with the large, sequential waves of the COVID-19 pandemic (Qian et al, 2007).…”