Percutaneous absorption of benzophenone-3 loaded lipid nanoparticles and polymeric nanocapsules: A comparative study

Gilbert, E.; Roussel, L.; Serre, C.; Sandouk, R.; Salmon, D.; Kirilov, Plamen; Haftek, Marek; Falson, Françoise; Pirot, Fabrice

doi:10.1016/j.ijpharm.2016.03.018

Cited by 35 publications

(18 citation statements)

References 42 publications

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“…Nanocapsules alone also demonstrated capacity to absorb UV light, while a synergistic effect could be shown when combining all three ingredients i.e., the oil, NCs, and the active ingredient (BZP-3). SPF of BZP3 is nevertheless dependent on its concentration in the formulation [12]. The incorporation of BZP3-NCs into the semi-solid formulation slightly increased the SPF values from 8.64 to 8.84.…”

Section: Controlmentioning

confidence: 98%

“…Polymeric nanocapsules (NCs) have been recognized to avoid the risk of photodegradation, as they reduce the risk of skin absorption of the active ingredient or may even increase the sun protection due to the occlusive barrier forming on the skin surface [12]. Due to these synergistic effects, higher effectiveness and higher safety may be achieved with a lower amount of UV filter loading the NCs.…”

Section: Introductionmentioning

confidence: 99%

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Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules

Barbosa

Nascimento

Bani

et al. 2019

Toxics

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The objective of this work was to characterize the toxicological profile of a newly developed sunscreen formulation based on polymeric nanocapsules (NCs) loading benzophenone-3 (BZP3). NCs composed of poly(ε-caprolactone) carrot oil and Pluronic® F68 were produced by emulsification-diffusion method. Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index (PDI) was below 0.37, while zeta potential (ZP) reached about |+11 mV|. No cytotoxic effects were observed in L929 fibroblast cell line for the blank (i.e., non-loaded) NCs and BZP3-loaded NCs (BZP3-NCs). The semi-solid sunscreen formulation was stable over time (centrifugation testing) and exhibited non-Newtonian pseudoplastic behavior, which is typical of products for topical application onto the skin. The sun protection factor (SPF) value reached 8.84, when incorporating BZP3-NCs (SPF of 8.64) into the semi-solid formulation. A synergistic effect was also observed when combining the formulation ingredients of nanocapsules, i.e., SPF of carrot oil was 6.82, blank NCs was 6.84, and BZP3-loaded NCs was 8.64. From the hen’s egg-chorioallantoic membrane test (HET-CAM) test, the non-irritation profile of the developed formulations could also be confirmed. The obtained results show a promising use of poly(ε-caprolactone) nanocapsules to be loaded with lipophilic sunscreens as benzophenone-3.

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Section: Controlmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules

Barbosa

Nascimento

Bani

et al. 2019

Toxics

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“…Adicionalmente, estes materiais mesoporosos apresentam elevada estabilidade térmica, hidrotérmica, química e mecânica, dependendo da espessura da parede do poro (DA SILVA et al, 2015;WANG et al, 2015). (ABID et al, 2017;DJAVAHERI-MERGNY et al, 1996;GILBERT et al, 2016;HANSON et al, 2015).…”

Section: ____________________________________________________________unclassified

“…através do tecido cutâneo, atingindo a circulação sistêmica e serem excretados na urina (GILBERT et al, 2013(GILBERT et al, , 2016LIAO;KANNAN, 2014). Janjua e colaboradores (2008) avaliaram a permeação cutânea in vivo, dos filtros orgânicos: 3-(4-metilbenzilideno), benzofenona-3 e p-metoxicinamato de octila.…”

Section: ____________________________________________________________unclassified

“…O valor de log P (3,79) e peso molecular (228,25 g mol -1 ) da BZF-3 permitem fácil permeabilidade do filtro através da pele. Apesar do MCO e AVO apresentarem baixo peso molecular 290,40 g mol -1 e 310,4 g mol -1 , respectivamente, os valores de coeficiente de partição destes compostos (5,80 para MCO e 4,51 para AVO) são elevados, o que os classificam como moléculas muito hidrofóbicas, motivo pelo qual estes filtros apresentaram baixa permeação cutânea (DURAND et al, 2009;KLIMOVÁ;HOJEROVÁ;BERÁNKOVÁ, 2015;OECD, 2011 (CROSS et al, 2001;GILBERT et al, 2016;WATKINSON et al, 2013). DANELUTI et al, 2017;DURAND et al, 2009;EREN et al, 2016;GILBERT et al, 2016;NETO et al, 2016).…”

Section: ____________________________________________________________unclassified

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Avaliação de protetores solares contendo filtros encapsulados/incorporados em matriz de sílica mesoporosa ordenada do tipo SBA-15

Daneluti¹

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Aos meus amados pais, Laercio e Sônia, por serem meu alicerce e maiores incentivadores. Não existem palavras para demonstrar meu amor e gratidão! A minha querida irmã, Cristiane, que considero como uma segunda mãe, e aos meus sobrinhos: Matheus, meu afilhado e Miguel o sapequina da família. Ao meu amado namorado, Urs, pelo amor, cumplicidade, parceria mesmo estando distante todo esse tempo. ii AGRADECIMENTOS À Deus, Jesus Cristo, Maria, todos os Anjos e Santos, pela constante proteção, plenitude e paz de espírito. À minha linda família, incluindo a Shakira minha fiel escudeira que está comigo há 12 anos, pelo amor, união e muitas alegrias! Ao meu co-orientador, educador e querido amigo, Prof. Dr. André Rolim Baby, pelos ensinamentos, crescimento e valores compartilhados. Não apenas um orientador, mas um professor exemplar! Serei eternamente grato! Ao meu orientador Prof. Dr. Jivaldo do Rosário Matos pela oportunidade, amizade, pelos ensinamentos compartilhados e que vem me acompanhando desde o mestrado. To Prof. Dr. Yogeshvar N. Kalia, for accepting and hosting me as visitor student for almost one year. Thank you so much for sharing your knowledge and expertise. À querida Profa. Dra. Maria Valéria Robles Velasco e a Profa. Dra. Vladi Olga Consiglieri pela parceria e carinho. À Profa. Dra. Luci Diva Brocardo Machado e Prof. Dr. Marlus Chorilli pelos valiosos ensinamentos durante o exame de qualificação. A todos os professores do Programa de Pós-Graduação em Fármaco e Medicamentos, que muito me ensinaram durante as disciplinas, reuniões e representação discente. Aos maravilhosos amigos do LATIG pelo apoio e suporte as horas difíceis: Roxana,

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Polymeric Nanoparticles

Guterres¹,

Paese²,

Pohlmann³

2019

Nanocosmetics

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Percutaneous absorption of benzophenone-3 loaded lipid nanoparticles and polymeric nanocapsules: A comparative study

Cited by 35 publications

References 42 publications

Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules

Development, Cytotoxicity and Eye Irritation Profile of a New Sunscreen Formulation Based on Benzophenone-3-poly(ε-caprolactone) Nanocapsules

Avaliação de protetores solares contendo filtros encapsulados/incorporados em matriz de sílica mesoporosa ordenada do tipo SBA-15

Polymeric Nanoparticles

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