SynopsisSunscreens provide broad-spectrum UV skin protection and contain more often UV filter combinations. Their efficacy reducing skin photo carcinogenesis and photo ageing is widely documented. However, there are many concerns about UV filter safety. Organic UV filters were the first targeted by scientist concerns, as they were showed to trigger skin allergic reactions. Inorganic UV filters were then at the heart of scientist debate especially because of their nanometric size. Over the last years, many studies have been published tending to highlight that organic as well as inorganic UV filters could lead to variable side effects after sunscreen application. However, these studies are still very controversial due to different experimental conditions and models. This review reveals that complementary studies using standardized methods are mandatory before ascertaining that UV filters threaten human health.
R esum eLes produits solaires destin es a prot eger la peau contre les irradiations UV contiennent le plus souvent des combinaisons de filtres UV. Ces filtres permettent de r eduire le vieillissement pr ematur e de la peau ainsi que la survenue de cancer cutan e. Cependant, la nocivit e des filtres UV est toujours un sujet de controverse. Ainsi, des r eactions allergiques li ees a l'utilisation de produits solaires contenant des filtres UV organiques ont et e rapport ees dans la litt erature. R ecemment, l'utilisation de filtres UV min eraux a l' echelle nanom etrique, dispers es dans les produits destin es a la protection solaire a fait l'objet de travaux scientifiques visant a etablir le niveau de p en etration cutan ee. Ces derni eres ann ees, de nombreuses etudes ont et e publi ees tendant a montrer que les filtres UV organiques et inorganiques peuvent entrainer divers effets ind esirables. Mais, ces diverses etudes restent tr es controvers ees notamment a cause des diff erences dans les conditions exp erimentales et les mod eles utilis es. Cette revue r ev ele que des etudes compl ementaires utilisant des m ethodes standardis ees sont n ecessaires pour confirmer ou infirmer que les filtres UV pr esentent un risque sanitaire.
The obtained results demonstrate the interest of these gelled nanoparticles and their aqueous dispersion for the preparation of new formulations for cosmetic and dermo-cosmetic applications.
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