Perbedaan Bermakna Kadar Serum Amiloid a Antara Stenosis Koroner Dibandingkan Bukan Stenosis Koroner

Abstract

Coronary stenosis is one of the major causes of death from heart disease. The gold standard of coronary stenosis diagnosis is established with angiography, however it is invasively, complicated and expensive. Serum Amyloid A (SAA) is an acute phase proteinthat appears as chronic and acute inflammatory agent that is specific to the process of stenosis development. Serum Amyloidal A test method is noninvasive, relatively easy and affordable. The aim of this study was to know the differences of Serum Amyloid A levels in patients with nonstenosis and coronary stenosis in Dr. Sardjito General Hospital Yogyakarta by determination. The study is a case control study. The samples were selected consecutively with typical chest pain, were divided into two (2) groups of nonstenosis and stenosis by coronary angiography test. The principal of the Serum Amyloid A test is ELISA method. Nonstenosis and coronary stenosis groups were analyzed by mean of Serum Amyloid A level based on the angiography test. The data were analyzed with Independent t-test, odds ratio with a significancy of p <0.05 and confidence interval 95%. The samples of this study consisted of 60 patients, divided into nonstenosis and coronary stenosis. The analysis of Independent t tests showed significant differences between the subject SAA levels of nonstenosis and stenosis (4.35 ug/mL vs 21.75 mg/mL, p=0.001, with an odds ratio 9.84 (CI 95% 2.38 to 40.73). Based on this study, it can be conclued that the results indicate significantly higher level of Amyloid A Serum among the coronary stenosis compared to the nonstenosis.